Publications

Export 1699 results:
Sort by: Author Title Type [ Year  (Desc)]
2016
Olagunju, A, Khoo S, Owen A.  2016.  Pharmacogenetics of nevirapine excretion into breast milk and infants' exposure through breast milk versus post-exposure prophylaxis. Pharmacogenomics. 10.2217/pgs-2015-0016(Epub ahead of print) Abstract

Aim: The influence of genetic factors on nevirapine (NVP) breast milk pharmacokinetics and breastfed infants’ exposure were investigated.

Patients & methods: Associations between nine SNPs in NVP disposition genes in mothers and its plasma and breast milk concentrations were explored in nursing mother–infant pairs.

Results: NVP pharmacokinetics in maternal plasma, breast milk and infant exposure indices were influenced by CYP2B6 516G>T and 983T>C. The median (range) milk-to-plasma area under the curve (AUC0–12) ratio was 0.95 (0.56–1.5). Calculated as percentages of pediatric treatment, infant postexposure prophylaxis and maternal weight-adjusted doses, the maximum exposure indices were 3.64% (1.99–9.88), 26.0% (9.93–79.1) and 13.8% (5.77–27.7), respectively. Infant plasma concentration as a result of exposure through breast milk (n = 93), pre-exposure prophylaxis (n = 10) and both (n = 27) were 660 (104–3090), 1020 (401–3325) and 2720 ng/ml (1360–7290), respectively.

Conclusion: The clinical significance of the observed differences between routes of infants’ exposure warrants further investigation.

Asubiojo, OI.  2016.  POLLUTION SOURCES IN THE NIGERIAN ENVIRONMENT AND THEIR HEALTH IMPLICATIONS. Ife Journal of Science. 18(4):973-980.asubiojo_12.pdf
Idowu, PA, OlutolaAgbelusi, Alademoko TA.  2016.  The Prediction of Paediatric HIV/AIDS Patient Survival: A Data Mining Approach. Asian Journal of Computer and Information Systems. 4(3):87-94.
Olagunju, A, Bolaji O, Megan N, Back D, Khoo S, Owen A.  2016.  Pregnancy affects nevirapine pharmacokinetics – evidence from a CYP2B6 genotype-guided observational study. Pharmacogenetics and Genomics. doi: 10.1097/FPC.0000000000000227(Epub ahead of print) Abstract

OBJECTIVES: Previous studies on nevirapine pharmacokinetics during pregnancy reported contradictory findings.

METHODS: The magnitude of pregnancy-induced changes in nevirapine pharmacokinetics was investigated in a genotype-guided study preceded by a pharmacogenetic association study of six genes involved in its disposition.

RESULTS: CYP2B6 516 G>T and 983 T>C were associated independently with plasma nevirapine concentrations in pregnant (n=110) and postpartum (n=122) women and were used for stratification. NR1I3 540C>T and P450 oxidoreductase 1508C>T were associated with lower and higher plasma concentrations in pregnant and postpartum women, respectively. In the intensive pharmacokinetic phase, apparent clearance (CL/F) was higher in pregnant (n=31) than postpartum (n=28) women (P=0.022) and AUC0-12, Cmax and Cmin were significantly lower. When stratified on the basis of composite CYP2B6 516 G>T and 983 T>C genotypes, CL/F was similar between pregnant (n=6) and postpartum (n=9) women with no variant alleles, but Cmin was below target (3400 ng/ml) in most patients in both groups. In women with one variant allele, clearance was 40.6% higher (P=0.0009) and Cmin was below target in 58% (11/19) of pregnant and 0% (0/10) of postpartum women. Similarly, clearance was 51.7% higher (P=0.008) in pregnant compared with postpartum women with two variant alleles. Cmin was below target in 50% (3/6) of pregnant and 0% (0/10) of postpartum women.

CONCLUSION: Nevirapine exposure is significantly reduced during pregnancy. The pharmacodynamic consequences in patients at risk of suboptimal exposure and potential dose optimization strategies warrant further investigation.

ASAOLU Taiwo, ADEDOKUN Samuel, MONDAYJ.  2016.  Promoting Good Governance through Internal Audit Function (IAF): The Nigerian Experience. International Business Research,. Vol. 9(5):196-204.my_paper_promoting_good_governance_through_iaf.pdf
Ojo, JO.  2016.  RADIOACTIVITY IN SOME FOODS AND SOILS FROM JOS TIN MINES, JOS, NIGERIA. Ife Journal of Science. 18(4):1065-1071.ojo_joshua_19.pdf
C, OO, O AW, I. A, B IN, A SA, I AM.  2016.  RESPONSE OF PLANKTON ASSEMBLAGE TO NUTRIENT AND ENVIRONMENT AL P ARAMETERS IN A TROPICAL COAST AL WATER. Ife Journal of Science. 18(3):801-811.ojelade_et_al_20.pdf
Abiola, OA, Oke AO, Koya OA, Adewole BZ.  2016.  Simulation study of typical auto-mechanics tasks. Leonardo Journal of Sciences. 29:13-24.
Fawole, OG, Owoade OK, Hopke PK, Olise FS, Ogundele LT, Adewole OO.  2016.  Source apportionment analyses for fine (PM2.5) and coarse (PM2.5e10) mode particulate matter (PM) measured in an urban area in southwestern Nigeria. Atmospheric Pollution Research. 7:1-15.
Fasina, TM, Dueke-Eze, Familoni OB, Idika N, Mphahlele MJ.  2016.  SYNTHESIS AND ANTIBACTERIAL PROPERTY STUDIES OF THE N'-(4-SUBSTITUTED) ISONICOTINOHYDRAZIDES AND THEIR COPPER (II) COMPLEXES. Ife Journal of Science. 18(3):595-603.fasina_et_al_2.pdf
Ogunbayo, TB, Akinbulu IA, Mbambisa G, Olusegun MA, Olafimihan JO.  2016.  SYTHESIS, CHARACTERIZATION AND Pd(II) IONS COORDINATION EQUILIBRIUM STUDIES OF a-OCT ASUBSTITUTED OCTYLTHIO- AND DODECYLTHIO-DERIVATSED PHTHALOCYANINES. Ife Journal of Science. 18(3):775-787.
Ogunkoya, OO.  2016.  URBAN PLANNING, DOWNSTREAM PETROLEUM INDUSTRY AND HUMAN HEALTH. Ife Journal of Science. 18(4):963-971.ogunkoya_11.pdf
Olajide, AA, George RC.  2016.  UV-VIS SPECTROSCOPY STUDY ON PORPHYRIN NANOSTRUCTURES FORMED BY ELECTROSTATIC INTERACTION. Ife Journal of Science. 18(3):585-593.olajide_and_george_1.pdf
Okusanya, OT, Shonubi OO, Bello OA, Bamidele JF.  2016.  VARIATION IN FLOWERING PHENOLOGY OF CASSIAFISTULALINN. POPULATION IN OTA, OGUN ST ATE. NIGERIA.. Ife Journal of Science. 18(4):887-894.
2015
OlutolaAgbelusi, Aladekomo TA, Idowu PA.  2015.  Prediction of Pediatric HIV/AIDS Survival in Nigeria Using Naïve Baye’s Approach, July 22-24. Information Technology for Inclusive Development. , Akure Nigeria
Aderibigbe, A, Ekemode BG, Adegoke OJ.  2015.  An Assessment of Land Title Registration in Osun Nigeria, 3 September. the 15th African Real Estate Society International Conference on Real Estate Markets Development: Meeting the Challenge, Making the Difference. , Golden Tulip Kumasi City Hotel, Kumasi, Ghana,
Adegoke, BF, Adegoke OJ.  2015.  Evaluation of Benefits of Women Participation in Homeownership in Nigeria, 3 September. 15th African Real Estate Society International Conference on Real Estate Markets Development: Meeting the Challenge, Making the Difference. , Golden Tulip Kumasi City Hotel, Kumasi, Ghana,