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In Press
Adebowale, OF.  In Press.   NEED FOR MEASURING VALUES ACQUISITION IN NIGERIAN EDUCATIONAL SYSTEM. . THE PEDAGOGICAL PSYCHOLOGY OF TEACHING AND LEARNINGS’.. , Abuja: National Open University of Nigeria
Oginni, FO, Oladele AO, Adenekan AT, Olabanji JK.  In Press.  Cleft Care in Nigeria: Past, Present and Future. Cleft palate Craniofacial Journal.
Oginni, FO, Braimah RO, Oladejo T, Adenekan AT.  In Press.  Congenital Heterotopic Gastrointestinal Cyst of the Tongue in a New-born: Case Report. International Journal of Oral and Maxillofacial Pathology. 4(3):1.
Oginni, FO, Oladejo T, Braimah RO, Adenekan AT.  In Press.  Sublingual epidermoid cyst in a neonate. Annals of Maxillofacial Surgery. 4(1):1.
2017
Adegoke, OJ, Aluko BT, Adegoke BF.  2017.  Determinants of Market Value of Residential Properties in Ibadan Metropolis, Nigeria. Journal of Economics and Sustainable Development. 8(4):178-188.
Waitt, C, Diliiy Penchala S, Olagunju A, Amara A, Else L, Lamorde M, Khoo S.  2017.  Development, validation and clinical application of a method for the simultaneous quantification of lamivudine, emtricitabine and tenofovir in dried blood and dried breast milk spots using LC–MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 1060:300-307. AbstractDownload (Open Access)

Objectives: To present the validation and clinical application of a LC–MS/MS method for the quantification of lamivudine (3TC), emtricitabine (FTC) and tenofovir (TFV) in dried blood spots (DBS) and dried breast milk spots (DBMS).

Methods: DBS and DBMS were prepared from 50 and 30 μL of drug-spiked whole blood and human breast milk, respectively. Following extraction with acetonitrile and water, chromatographic separation utilised a Synergi polar column with a gradient mobile phase program consisting of 0.1% formic acid in water and 0.1% formic acid in acetonitrile. Detection and quantification was performed using a TSQ Quantum Ultra triple quadrupole mass spectrometer. The analytical method was used to evaluate NRTI drug levels in HIV-positive nursing mothers-infant pairs.

Results: The assay was validated over the concentration range of 16.6–5000 ng/mL for 3TC, FTC and TFV in DBS and DBMS except for TFV in DBMS where linearity was established from 4.2–1250 ng/mL. Intra and inter-day precision (%CV) ranged from 3.5–8.7 and accuracy was within 15% for all analytes in both matrices. The mean recovery in DBS was >61% and in DBMS >43% for all three analytes. Matrix effect was insignificant. Median AUC0-8 values in maternal DBS and DBMS, respectively, were 4683 (4165–6057) and 6050 (5217–6417) ng h/mL for 3TC, 3312 (2259–4312) and 4853 (4124–6691) ng h/mL for FTC and 1559 (930–1915) and 56 (45–80) ng h/mL for TFV. 3TC and FTC were quantifiable (>16.6 ng/mL) in DBS from 2/6 and 1/6 infants respectively whereas TFV was undetectable in all infants.

Conclusions: DBS and DBMS sampling for bioanalysis of 3TC, FTC and TFV is straightforward, robust, accurate and precise, and ideal for use in low-resource settings.

Neary, M, Lamorde M, Olagunju A, Darin KM, Merry C, Byakika-Kibwika P, Back DJ, Siccardi M, Owen A, Scarsi KK.  2017.  The Effect of Gene Variants on Levonorgestrel Pharmacokinetics when Combined with Antiretroviral Therapy containing Efavirenz or Nevirapine. Clinical Pharmacology & Therapeutics . (DOI: 10.1002/cpt.667) AbstractJournal Website

Reduced levonorgestrel concentrations from the levonorgestrel contraceptive implant was previously seen when given concomitantly with efavirenz. We sought to assess whether single nucleotide polymorphisms (SNPs) in genes involved in efavirenz and nevirapine metabolism were linked to these changes in levonorgestrel concentration. SNPs in CYP2B6, CYP2A6, NR1I2 and NR1I3 were analysed. Associations of participant demographics and genotype with levonorgestrel pharmacokinetics were evaluated in HIV-positive women using the levonorgestrel implant plus efavirenz- or nevirapine-based ART, in comparison to ART-naïve women using multivariate linear regression. Efavirenz group: CYP2B6 516G>T was associated with lower levonorgestrel log10 Cmax and log10 AUC. CYP2B6 15582C>T was associated with lower log10 AUC. Nevirapine group: CYP2B6 516G>T was associated with higher log10 Cmax and lower log10 Cmin . Pharmacogenetic variations influenced subdermal levonorgestrel pharmacokinetics in HIV-positive women, indicating that the magnitude of the interaction with non-nucleoside reverse transcriptase inhibitors (NNRTIs) is influenced by host genetics.