Publications

Export 1699 results:
Sort by: Author Title Type [ Year  (Desc)]
2015
Oyebola, OO, Ogungbemi KI, Olopade MA.  2015.  COMPARISON OF THE EMISSION PROPERTIES OF Ho :KPb Cl AND Ho :CaF 2 5 2 CRYSTALS. Ife Journal of Science. 17(2)
Fawole, OG, Olofinjana B, Owoade OK.  2015.  Compositional and Air-mass Trajectory Analysis of a Heavy Dust Episode (HDE) Aerosols in Ile-Ife, Nigeria. British Journal of Applied Science & Technology. 13(1):1-15.bjast_hde_paper.pdf
ADESOLA, F.  2015.  Congo DR and the Intrigues of Resource-Based Conflict. African Research Review. Vol. 9(1, S/No. 36):62-72.
Ogunwande, GA, Akinola EO, Lana AR.  2015.  DEVELOPMENT OF A BIOGAS-POWERED POULTRY EGG INCUBATOR. Ife Journal of Science. 17(1)ogunwande_et_al_20.pdf
Idowu, PA, Ajibola SO, jeremiah Balogun A, Ogunlade O.  2015.  Development of a Fuzzy Logic Based Model for Monitoring Cardiovascular Disease Risk. Journal of Health Information Systems and Informatics. 10(4):38-55.
Olagunju, A, Bolaji OO, Amara A, Waitt C, Else L, Soyinka J, Adeagbo B, Adejuyigbe E, Siccardi M, Back D, Owen A, Khoo S.  2015.  Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS. Journal of Antimicrobial Chemotherapy. 70(2):555-61. AbstractWebsite

Objectives This manuscript describes the development, validation and clinical application of a novel method for the quantification of the antiretroviral drug efavirenz in dried breast milk spots using LC-MS.

Methods Dried breast milk spots were prepared by spotting 30 μL of human breast milk on each circle of Whatman 903 Protein Saver cards. Chromatographic separation was achieved on a reverse-phase C18 column with 1 mM ammonium acetate in water/acetonitrile using a solvent gradient at a flow rate of 400 μL/min and detection was by TSQ Quantum Access triple quadrupole mass spectrometer equipped with a heated electrospray ionization source. The method was applied to characterize the breast milk pharmacokinetic profile of efavirenz in HIV-positive nursing mothers receiving regimens containing 600 mg of efavirenz once daily.

Results The assay was validated over the concentration range 50–7500 ng/mL. Accuracy ranged between 95.2% and 102.5% and precision ranged between 1.05% and 9.53%. The average recovery of efavirenz from dried breast milk spots was 106.4% and the matrix effect was 8.14%. Stability of efavirenz in dried breast milk spots and processed samples at room temperature, −40°C and −80°C was demonstrated. In the pharmacokinetic study, the mean (SD) AUC0–24, Cmax and Cmin of efavirenz in breast milk were 59 620 ng·h/mL (17 440), 4527 ng/mL (1767) and 1261 ng/mL (755.9), respectively. The mean (range) milk-to-plasma concentration ratio over the dosing interval was 0.78 (0.57–1.26).

Conclusions The dried breast milk spot method is simple, robust, accurate and precise, and can be used in settings with limited resources.

Olagunju, A, Bolaji O, Amara A, Waitt C, Else L, Soyinka J, Babatunde A, Adejuyigbe E, Siccardi M, Back D, Owen A, Khoo S.  2015.  Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS. Journal of Antimicrobial Chemotherapy. 70(2):55-61. Abstract

OBJECTIVES: This manuscript describes the development, validation and clinical application of a novel method for the quantification of the antiretroviral drug efavirenz in dried breast milk spots using LC-MS.

METHODS: Dried breast milk spots were prepared by spotting 30 μL of human breast milk on each circle of Whatman 903 Protein Saver cards. Chromatographic separation was achieved on a reverse-phase C18 column with 1 mM ammonium acetate in water/acetonitrile using a solvent gradient at a flow rate of 400 μL/min and detection was by TSQ Quantum Access triple quadrupole mass spectrometer equipped with a heated electrospray ionization source. The method was applied to characterize the breast milk pharmacokinetic profile of efavirenz in HIV-positive nursing mothers receiving regimens containing 600 mg of efavirenz once daily.

RESULTS: The assay was validated over the concentration range 50-7500 ng/mL. Accuracy ranged between 95.2% and 102.5% and precision ranged between 1.05% and 9.53%. The average recovery of efavirenz from dried breast milk spots was 106.4% and the matrix effect was 8.14%. Stability of efavirenz in dried breast milk spots and processed samples at room temperature, -40°C and -80°C was demonstrated. In the pharmacokinetic study, the mean (SD) AUC0-24, Cmax and Cmin of efavirenz in breast milk were 59,620 ng·h/mL (17,440), 4527 ng/mL (1767) and 1261 ng/mL (755.9), respectively. The mean (range) milk-to-plasma concentration ratio over the dosing interval was 0.78 (0.57-1.26).

CONCLUSIONS: The dried breast milk spot method is simple, robust, accurate and precise, and can be used in settings with limited resources.

Oluwagbenga, OOI.  2015.  Ecological Degradation under Selected Tree Crop Ecosystems in Ondo State, South-western Nigeria. . Frontiers in Environmental Research and Sustainable Environment in the 21st Century. , Ibadan: Ibadan University Pressoluwagbenga_o.i._orimoogunje_ecological_degradation_under___selected_tree_crop_ecosystems_in_ondo_state.pdf
MONDAY James, AGORZIE Claudius, BELLOAJAMES-UNAMF.  2015.  Enhancing Sustainable Development of Small and Medium-Scale Enterprises through Total Quality Management: Evidence from Nigeria. Ife Journal of Entrepreneurship and Business Management, . Vol. 1(1):25-37.articles_9_-_monday_-_tqm_in_smes_ifeds_final_correction.pdf
Olorunfemi, * D. I., Olorunfemi * DI, Ayemoba G.  2015.  ESTIMATION OF ACUTE TOXICITY OF BILGE WATER TO THE AFRICAN CATFISH [Clarias gariepinus (BURCHELL 1822)] JUVENILES. Ife Journal of Science. 17(2)olorunfemi_et_al_16.pdf
Ugbaja, RN, Owoeye FD, Dedeke GA, Akinloye OA.  2015.  AN EVALUATION OF SORGHUM BICOLOR (Linn.) MOENCH LEAF SHEATH EXTRACT IN HIGH FAT DIET-INDUCED OBESE RATS. IJS. III:667-683.