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2015
Olagunju, A, Bolaji O, Amara A, Waitt C, Else L, Soyinka J, Babatunde A, Adejuyigbe E, Siccardi M, Back D, Owen A, Khoo S.  2015.  Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS. Journal of Antimicrobial Chemotherapy. 70(2):55-61. Abstract

OBJECTIVES: This manuscript describes the development, validation and clinical application of a novel method for the quantification of the antiretroviral drug efavirenz in dried breast milk spots using LC-MS.

METHODS: Dried breast milk spots were prepared by spotting 30 μL of human breast milk on each circle of Whatman 903 Protein Saver cards. Chromatographic separation was achieved on a reverse-phase C18 column with 1 mM ammonium acetate in water/acetonitrile using a solvent gradient at a flow rate of 400 μL/min and detection was by TSQ Quantum Access triple quadrupole mass spectrometer equipped with a heated electrospray ionization source. The method was applied to characterize the breast milk pharmacokinetic profile of efavirenz in HIV-positive nursing mothers receiving regimens containing 600 mg of efavirenz once daily.

RESULTS: The assay was validated over the concentration range 50-7500 ng/mL. Accuracy ranged between 95.2% and 102.5% and precision ranged between 1.05% and 9.53%. The average recovery of efavirenz from dried breast milk spots was 106.4% and the matrix effect was 8.14%. Stability of efavirenz in dried breast milk spots and processed samples at room temperature, -40°C and -80°C was demonstrated. In the pharmacokinetic study, the mean (SD) AUC0-24, Cmax and Cmin of efavirenz in breast milk were 59,620 ng·h/mL (17,440), 4527 ng/mL (1767) and 1261 ng/mL (755.9), respectively. The mean (range) milk-to-plasma concentration ratio over the dosing interval was 0.78 (0.57-1.26).

CONCLUSIONS: The dried breast milk spot method is simple, robust, accurate and precise, and can be used in settings with limited resources.

Oluwagbenga, OOI.  2015.  Ecological Degradation under Selected Tree Crop Ecosystems in Ondo State, South-western Nigeria. . Frontiers in Environmental Research and Sustainable Environment in the 21st Century. , Ibadan: Ibadan University Pressoluwagbenga_o.i._orimoogunje_ecological_degradation_under___selected_tree_crop_ecosystems_in_ondo_state.pdf
MONDAY James, AGORZIE Claudius, BELLOAJAMES-UNAMF.  2015.  Enhancing Sustainable Development of Small and Medium-Scale Enterprises through Total Quality Management: Evidence from Nigeria. Ife Journal of Entrepreneurship and Business Management, . Vol. 1(1):25-37.articles_9_-_monday_-_tqm_in_smes_ifeds_final_correction.pdf
Olorunfemi, * D. I., Olorunfemi * DI, Ayemoba G.  2015.  ESTIMATION OF ACUTE TOXICITY OF BILGE WATER TO THE AFRICAN CATFISH [Clarias gariepinus (BURCHELL 1822)] JUVENILES. Ife Journal of Science. 17(2)olorunfemi_et_al_16.pdf
Ugbaja, RN, Owoeye FD, Dedeke GA, Akinloye OA.  2015.  AN EVALUATION OF SORGHUM BICOLOR (Linn.) MOENCH LEAF SHEATH EXTRACT IN HIGH FAT DIET-INDUCED OBESE RATS. IJS. III:667-683.
Gbadegesin, AS, Eze EB, Oluwagbenga OOI, Fashae OA.  2015.  Frontiers in Environmental Research and Sustainable Environment in the 21st Century. , Ibadan: Ibadan University Press AbstractFrontiers in Environmental Research and Sustainable Environment in the 21st Century_Contents

The primary object of this book is to present current issues and problems relating to environmental sustainability and to discuss them as elements of the earth’s surface. This book is timely because of the widespread interest in geographical approaches to solving environmental problems. However, the celebration of the two Giants of Geography – Emeritus Professor Adetoye Faniran and Professor Olusegun Areola from the Department of Geography, University of Ibadan, Nigeria afforded scholars to share their interest especially because of the opportunity to celebrate the erudite Giants by holding a National Colloquium on Frontiers in Environmental Research and Sustainable Environment in the 21st Century. The collections of articles in this book result from the scholars’ concerns to evaluate environmental geographical applicability to environmental management in several natural resource fields. The study of such complexes requires more than one individual. This has led to the concept of interdisciplinary research which involves diversity of skills and specialties. Environmental geography has for some time been prominent in research and management studies, but only a few components have been measured or considered in most instances.

Balogun, VS, Oluwagbenga OOI.  2015.  Geo-Spatial Mapping of Air Pollution in Benin City, Nigeria . Journal of Geography, Environment and Earth Science International . 3(3):1-17.geo-spatial_mapping_of_air_pollution_in_benin_city_nigeria.pdf
Ogunseiju, P, Ajayi TR, Olarewaju VO.  2015.  GEOCHEMICAL ASSESSMENT OF THE IMPACT OF AN ACTIVE OPEN DUMPSITE ON SOIL IN IBADAN, SOUTHWESTERN NIGERIA. IJS. III:715-727.
Okiyi, IM, Olorunfemi MO, Ojo JS, Akintorinwa OJ, Bayode S.  2015.  GEOELECTRIC INVESTIGATION OF A SITE FOR A PROPOSED AIRPORT IN EBONYI STATE, SOUTHEAST NIGERIA.. Ife Journal of Science. 17(2)okiyi_et_al_8.pdf
O., A, A. OA, O. OA.  2015.  GEOPHYSICAL AND HYDROGEOCHEMICAL EVALUATION OF A SPRING IN ADO-EKITI,SOUTH-WESTERN NIGERIA. Ife Journal of Science. 17(1)
Idowu, OA, Martins, O., O. O, Awomeso JA, Olaoye OA.  2015.  GROUNDWATER RECHARGE USING BASEFLOW RECESSION ANALYSIS IN SOUTHWESTERN NIGERIA. Ife Journal of Science. 17(1)idowu_et_al_19.pdf
Adeoye, AA, Udoh JE, Rotimi EA, Ikeobi CON, Adebambo OA.  2015.  HAEMATOLOGY AND SERUM BIOCHEMISTRY OF F AND F PIGS PRODUCED BY 1 2 ASF- RECOVERED PIGS. Ife Journal of Science. 17(2)adeoye_et_al_5.pdf
Jaiyeola, TG, Popoola BA.  2015.  Holomorph of generalized Bol loops II. Discussiones Mathematicae-General Algebra and Applications (doi:10.7151/dmgaa.1234). 35(1):59–78.
Adeyemi, BA.  2015.  Identification, Handling and Eradication of Corruption in Teaching, Research and Publication in Higher Institutions in Nigeria. Education Today: Imperatives of Quality Assurance. , Ile-Ife: Obafemi Awolowo University Press Ltd