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Traditional medicine has been playing a crucial role in developing countries as it provides primary health care needs for a large majority of the population. This article reviews the current research on the phytochemicals, nutritive value, ethnobotanical uses, and pharmacological importance of Momordica charantia. The phytochemical analysis of this plant revealed that the plant is rich in nutrients and phytochemicals which are of great benefit. Also, the plant is among the plants popularly used in traditional medicine and has been proved to be effective. The biological activities of the plants had been carried out by many authors and their results have been documented. In addition, among the biological activities of these plant are antidiabetic, antiulcer, anti-inflammatory, antioxidant, hypolipidemic, antibacterial, antimicrobial, antimalaria, antiviral, anticancer and antifertility. Moreover, some bioactive constituents such as alkaloids, tannins, flavonoids, saponins, glycosides, sterols, mucilages, and oleanolic acids are significantly present in the plant. It is now obvious that Momordica chlarantia can help as a natural source product in the treatment of many diseases particularly diabetes, cancers, cardiac, liver and kidney, malaria, and skin infection when properly administered.