Adebajo, AC, Famuyiwa FG, John JD, Idem ES, Aliyu AF, Adeoye AO.
2013.
Determination of Properties Useful for Sourcing Nigerian Phytolarvicides, 1–5th Sept, 2013. 61st Conference of the Gesellschaft für Arzneipflanzenforschung (GA),Planta Medica; 79(13): PE11. 79, Number 13, Institut für Pharmazeutische Biologie und Phytochemie, WWU, Münster, Germany: Georg Thieme Verlag {KG}
Abstract
Adebajo, AC, Ayoola MD, Odediran SA, Aladesanmi AJ, Schmidt TJ, Verspohl EJ.
2012.
P 29: Insulinotropic constituents and evaluation of ethnomedical claim of Gongronema latifolium root and stem, 15-17th November. 5th Annual Meeting of the Diabetes and Cardio-vascular Disease EASD Study Group, Diabetes and Metabolism; 38(Suppl. 5), S115. Poster 29 . 38:S115., Paris, France: Elsevier {BV}
Abstract
Adebajo, AC, Odediran SA, Rukunga GM, Ademowo OG, Schmidt TJ, Verspohl EJ.
2013.
Evaluation of ethnomedical claims: Antiplasmodial and anti-hyperglycaemic activities of Gongronema latifolium root and stem, 1-5th Sept, 2013. 61st Conference of the Gesellschaft für Arzneipflanzenforschung (GA), Planta Medica; 79(13): PE1. 79, Number 13, Institut für Pharmazeutische Biologie und Phytochemie, WWU, Münster, Germany: Georg Thieme Verlag {KG}
Abstract
Adebajo, AC, Olawode EO, Omobuwajo OR, Adesanya SA, Begrow F, Elkhawad A, Akanmu MA, Edrada R, Proksch P, Schmidt TJ, Klaes M, Verspohl EJ.
2007.
Hypoglycaemic Constituents of Stachytarpheta cayennensis Leaf. Planta Medica. 73(3):241-250., Number 3
Abstract
Adebajo, AC, Ayoola MD, Odediran SA, Aladesanmi AJ, Schmidt TJ, Verspohl EJ.
2013.
Evaluation of Ethnomedical Claim III: Anti-hyperglycemic activities of Gongronema latifolium root and stem. Journal of Diabetes. 5(3):336-343., Number 3
AbstractAbstract Background The insulinotropic activity of the combined root and stem of Gongronema latifolium (Asclepiadaceae) was evaluated to justify its African ethnomedicinal use in the management of diabetes. Methods A methanolic extract and its chromatographic fractions (A1–A6) were tested for glucose-reducing and in vitro insulin-stimulating abilities using glucose-loaded rats and INS-1 cells, respectively. In vivo insulin-releasing activities for the significantly (P < 0.05) active antihyperglycemic A5 and A6 and in vitro insulinotropic activity of the C1 fraction and its isolated constituents were also similarly determined. Results The extract (100 mg/kg) had higher in vivo antihyperglycemic activity than the individual A1–A6, indicating a synergistic effect of the plant constituents. Higher in vivo insulin release in response to A5 (100 mg/kg) than A6, agreed with their in vivo antihyperglycemic activities and confirmed insulin release as a mechanism of action of the plant. Compared with 5.6 mmol/L glucose (negative control), the extract and the A3, A6, and C1 (all at 100.0 μg/mL) elicited significantly higher in vitro insulin release that was similar to that of glibenclamide (1.0 μg/mL; P > 0.05). Fraction C1 yielded a 1:1 mixture of α-amyrin and β-amyrin cinnamates (1a:1b), lupenyl cinnamate (2), lupenyl acetate (3), and two unidentified triterpenoids, Y and Z. The 1a:1b mixture (100.0 μg/mL) demonstrated the highest insulinotropic activity that was comparable (P > 0.05) to that of glibenclamide (1.0 μg/mL). Conclusions The results confirm pancreatic activity as a mechanism underlying the antidiabetic action of G. latifolium and justify its ethnomedical use.
Adebajo, AC, Rukunga GM, Schmidt TJ, Verspohl EJ.
2013.
Evaluation of Nigerian ethnomedical plants for anti-infective and antidiabetic properties, 1–5th Sept, 2013. 61st Conference of the Gesellschaft für Arzneipflanzenforschung (GA), Planta Medica; 79(13): SL21. 79, Number 13, Institut für Pharmazeutische Biologie und Phytochemie, WWU, Münster, Germany: Georg Thieme Verlag {KG}
Abstract
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