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Conference Paper
Fisusi, A, Grace D, Mitchell P.  2013.  Energy Efficient Cluster-Based Resource Allocation and Topology Management for Beyond Next Generation Mobile Broadband Networks, 9-13 June. 2013 IEEE International Conference on Communications Workshops (ICC). , Budapest, Hungary.
Olabanji, SO, Omobuwajo OR, Adebajo AC, Ceccato D, Buoso MC, Moschini G.  2013.  PIXE analysis of some anti-diabetic medicinal plants in Nigeria, 3-8th Mar, 2013. PIXE 2013: International Conference on Particle-Induced X-Ray Emission for Technology and Global Development. , Gramado, RS (Brazil)
Olagunju, A, Amara A, Tjia J, Siccardi M, Oyigboja J, Bolaji O, Khoo S, Owen A.  2013.  Exposure of Breastfed Infants to Maternal Efavirenz from Breast Milk (Abstract #933), 3-6 March. 20th Conference on Retroviruses and Opportunistic Infections (CROI). , Atlanta, GA, USA Abstract

Background: Despite the risk of HIV transmission, breastfeeding is the preferred and recommended feeding option for infants born to HIV+ mothers in low- and middle-income countries. This is because reduction in HIV transmission associated with the avoidance of breastfeeding is counter-balanced by increases in morbidity and mortality from other causes. Efavirenz (EFV), used in these settings, is contraindicated in children <3 years old or 10 kg. However, it is used by nursing mothers and very limited data are available on its excretion into human breast milk. The aim of this study was to investigate the level of exposure of breastfed infants to maternal EFV through breast milk.

Methods: 34 HIV+ nursing mothers taking 600 mg EFV once daily as part of HAART and their exclusively breastfed infants were recruited from 2 Nigerian hospitals. Mid-dose dried blood spots were collected from mothers (untimed for babies) and EFV concentrations were determined using a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Univariate (dependent-sample t-test) and multivariate analyses (multiple linear regression) were used to assess relationships between patient demographics and EFV concentrations in mother and infants. p <0.05 was considered to be statistically significant.

Results: Median maternal and infant EFV concentrations were 1300 (95% confidence interval [CI] 950, 2200; range 72, 6200) and 96 (95%CI 50, 160; range <25, 2600) ng/mL, respectively (ratio 0.06 [95%CI 0.04, 0.09]). Maternal EFV concentration was within therapeutic range for 59%, >4000 ng/mL in 12% and <1000 ng/mL in 29%. Only about 5% of the infants had EFV concentrations >1000 ng/mL. There was a significant correlation between maternal and infant EFV concentrations (p = 2.2E-6; r = 0.65). In multivariate analysis, maternal EFV concentration (p = 2.9E-7) and infant body weight (p = 0.03) were significantly correlated with infant EFV concentrations, accounting for >50% of observed variance.

Conclusions: Breastfed infants are exposed to maternal EFV through breast milk. However, the target concentration for prevention of infection in breastfed, uninfected infants is unknown. Therefore, breastfed infants need to be closely monitored for toxicity and emergence of NNRTI resistance, which may limit therapeutic options in those who eventually become infected with HIV.

Siccardi, M, Olagunju A, Curley P, Hobson J, Khoo S, Back D, Owen A.  2013.  Prediction of Etravirine Pharmacogenetics Using a Physiologically Based Pharmacokinetic Approach (Abstract #888), 3-6 March. 20th Conference on Retroviruses and Opportunistic Infections (CROI). , Atlanta, GA, USA Abstract

Background: Etravirine (ETV) is metabolized by CYP3A4 and CYP2C19. A known inhibitor of CYP2C19, omeprazole increases ETV exposure by 41%. Since CYP2C19*2 (rs4244285) can affect CYP2C19 expression there is the potential to alter ETV exposure. We previously showed utility of physiologically based PK (PBPK) models for predicting genetic associations and drug-drug interactions from in vitro data in the absence of clinical data. The aim of this study was to develop a PBPK model for ETV PK and predict effects of CYP2C19*2 in virtual human subjects.

Methods: A new open-source PBPK model was developed with algorithms describing covariance between demographics and organ size, hepatic metabolism, induction of metabolic enzymes, expression, and mechanisms regulating absorption and distribution. In vitro data describing chemical properties as well as absorption, distribution, metabolism, and elimination of ETV were used to simulate ETV PK at 200 mg twice daily in 200 virtual subjects. Simulated PK parameters, such as Ctrough, Cmax, and AUC were compared with observed values from the literature. The impact of CYP2C19*2 on ETV clearance was then determined by altering CYP2C19 expression in the model. All simulations were conducted using the differential equation solver Berkeley Madonna.

Results: Simulated PK variables at steady state (mean ± SD) were Ctrough (293 ± 185 ng/mL), Cmax (363 ± 207 ng/mL), and AUC (4005 ± 2364 ng/mL.h), in agreement with previous clinical PK data: Ctrough (297 ± 391 ng/mL) and AUC (4522 ± 4710 ng/mL.h). Simulated mean ETV clearance (CL/F), volume of distribution, and ka were 59 ± 31 (L/h), 14.9 ± 3.6 L/kg, and 0.17 ± 0.011 hr–1, respectively. ETV (CL/F) was predicted to be 62 ± 35, 53 ± 31, and 41 ± 28 L/h for CYP2C19 *1/*1, *1/*2 and *2/*2, respectively.

Conclusions: The IVIVE model predicted in vivo PK of ETV in individuals with different CYP2C19 genotypes. The frequency of CYP2C19*2 has a higher frequency in Asian populations which may underpin heterogeneity in ETV exposure. Mechanistic evaluation of disposition can inform PBPK models and prediction of pharmacogenetic associations. IVIVE may be particularly helpful for the rational design of novel regimens for use in stratified populations. This includes prediction of optimal dose and dosing regimen, selection of partner drugs and validation of the likely overall pharmacological effect of discrete molecular processes, all of which can and should be tested in clinical studies.

Adebajo, AC, Ayoola MD, Obagbemi OR, Obuotor EM, Ogunsina OM, Pinkoane M, Verspohl EJ.  2013.  Antihyperglycaemic and Anti-oxidant Activities of Eugenia uniflora Leaf: Evaluation of Ethnomedical Claims {IV}, 1–5th Sept, 2013. 61st Conference of the GA, Planta Medica; 79(13): PE2. 79, Number 13, Institut für Pharmazeutische Biologie und Phytochemie, WWU, Münster, Germany: Georg Thieme Verlag {KG} Abstract

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Adebajo, AC, Famuyiwa FG, John JD, Idem ES, Aliyu AF, Adeoye AO.  2013.  Determination of Properties Useful for Sourcing Nigerian Phytolarvicides, 1–5th Sept, 2013. 61st Conference of the Gesellschaft für Arzneipflanzenforschung (GA),Planta Medica; 79(13): PE11. 79, Number 13, Institut für Pharmazeutische Biologie und Phytochemie, WWU, Münster, Germany: Georg Thieme Verlag {KG} Abstract

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Adebajo, AC, Rukunga GM, Schmidt TJ, Verspohl EJ.  2013.  Evaluation of Nigerian ethnomedical plants for anti-infective and antidiabetic properties, 1–5th Sept, 2013. 61st Conference of the Gesellschaft für Arzneipflanzenforschung (GA), Planta Medica; 79(13): SL21. 79, Number 13, Institut für Pharmazeutische Biologie und Phytochemie, WWU, Münster, Germany: Georg Thieme Verlag {KG} Abstract

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Adebajo, AC, Aliyu AF, Odediran SA, Nwafor PA, Nwoko TN, Umana SU, Adeoye AO.  2013.  In vivo antiplasmodial activities of four Nigerian medicinal plants, 1–5th Sept, 2013. 61st Conference of the Gesellschaft für Arzneipflanzenforschung (GA), Planta Medica; 79(13): PE3. 79, Number 13, Institut für Pharmazeutische Biologie und Phytochemie, WWU, Münster, Germany: Georg Thieme Verlag {KG} Abstract

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Famuyiwa, FG, Adebajo AC.  2013.  Larvicidal Activities of the Leaves of Eugenia uniflora L. (Myrtaceae), 1–5th Sept, 2013. 61st Conference of the Gesellschaft für Arzneipflanzenforschung (GA), Planta Medica; 79(13): PE12. 79, Number 13, Institut für Pharmazeutische Biologie und Phytochemie, WWU, Münster, Germany: Georg Thieme Verlag {KG} Abstract

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Adebajo, AC, Odediran SA, Rukunga GM, Ademowo OG, Schmidt TJ, Verspohl EJ.  2013.  Evaluation of ethnomedical claims: Antiplasmodial and anti-hyperglycaemic activities of Gongronema latifolium root and stem, 1-5th Sept, 2013. 61st Conference of the Gesellschaft für Arzneipflanzenforschung (GA), Planta Medica; 79(13): PE1. 79, Number 13, Institut für Pharmazeutische Biologie und Phytochemie, WWU, Münster, Germany: Georg Thieme Verlag {KG} Abstract

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Panighel, M, DiSanto G, Caputo M, Lal C, Taleatu BA, Goldoni A.  2013.  Review of 2H-tetraphenylporphyrins metalation in ultra-high vacuum on metal surfaces. IOP Conf. Series. , Trieste, Italy
Bamimore, A, Ogunba KS, Ogunleye MA, Osunleke AS, Taiwo O.  2012.  Implementation of Advanced Control Laws on a Laboratory-Scale Three-Tank System, 26 September. Annual Faculty of Technology Conference. , Ile-Ife, Nigeria
Adekoya, SO, Eleruja MA, Olofinjana B, Akinwunmi OO, Taleatu BA, Ajayi EOB.  2012.  Enhanced Light Absorption in Textured Metal Organic Chemical Vapour Deposited (MOCVD) CdO Thin Films, 2011. MRS Proceedings. 1432(1), San Fransisco, USA
Adebajo, AC, Ayoola MD, Odediran SA, Aladesanmi AJ, Schmidt TJ, Verspohl EJ.  2012.  P 29: Insulinotropic constituents and evaluation of ethnomedical claim of Gongronema latifolium root and stem, 15-17th November. 5th Annual Meeting of the Diabetes and Cardio-vascular Disease EASD Study Group, Diabetes and Metabolism; 38(Suppl. 5), S115. Poster 29 . 38:S115., Paris, France: Elsevier {BV} Abstract

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Adebajo, AC.  2012.  P28 Some Contributions to the Evaluation of Ethnomedical Antidiabetic Claims of African Medicinal Plants, 15-17th November. 5th Annual Meeting of the Diabetes and Cardio-vascular Disease EASD Study Group, Diabetes and Metabolism; 38(Suppl. 5), S114-115. Poster 28. , Paris, France
Ola-Olorun, OJ, Afolabi MO, Ogunsina AO, Oyebisi TO, Akinyemi OA, Akintomide AO, Adebayo RA.  2012.  Exploring medicine information needs of hypertensive patients using short message service (SMS) of mobilie phone. Pharmacoepidemiology and Drug Safety. 21:116–116., Number 1: WILEY PERIODICALS, INC COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA Abstract
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Aransiola, EF, Ojumu TV, Oyekola O, Ikhu-Omoregbe DIO.  2012.  A study of biodiesel production from non-edible oil seeds: A comparative study. : The Open Conference Proceedings Journal Abstract
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Famuyiwa, FG, Adebajo AC, Aladesanmi JA.  2011.  Larvicidal activity of Eugenia uniflora in Aedes aegyptii, 4-9th September. 59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Planta Medica; 77(12): PM183. 77, Number 12, Antalya, Turkey: Georg Thieme Verlag {KG} Abstract

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Akinwale, OB, Ayodele KP, Jubril AM, Kehinde LO, Osasona O, Akinwunmi O, Asiimwe AT, Mwikirize C, Musasizi PI, Togboa ST, Katumba A, Butime J, Nombo JP, Baraka MM, Teyana S, Mwambela JA.  2011.  Online Laboratories: Enhancing the Quality of Higher Education in Africa, 31 May. Conference of Rectors, Vice Chancellors and Presidents of Universities. , Stellenbosch, South Africailab_africa_paper.pdfilab_africa_paper_presentation.pdf
Fisusi, AA, Adeniran SA, Awe OP.  2011.  Direct Sequence CDMA System using Finite-Time Altered Sinusoidal Signals as Orthogonal Signatures, 24-26 November . 3rd IEEE International Conference on Adaptive Science and Technology (ICAST 2011). , Abuja, Nigeria
Dada, JO.  2011.  Factors affecting women enrolment in construction education in Nigeria. WEST AFRICA BUILT ENVIRONMENT RESEARCH (WABER) CONFERENCE 19-21 July 2011 Accra, Ghana. :453. Abstract
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A.Ajayi, C.  2010.  A Perspective of Real Estate Investment Opportunities in the Emerging Market of Nigeria. A Keynote Paper presented at the National CPD Workshop organized by the Nigerian Institution of Estate Surveyors and Valuers. , Abuja