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Owolabi, MO, Salaam K, Ogunniyi A, Ogbole GO, Akinyemi R, Mongkolwat P, Omisore AD, Agunloye AM, Makanjuola A, Efidi R, Odo J, Akpalu A, Sarfo F, Owolabi L, Obiako R, Wahab K, Adebayo P, Komolafe A, Osaigbovo G, Sunmonu T, Olowoyo P, Chukwuonye I, Obiabo Y, Ibinaiye P, Dambatta A, Mensah Y, Abdul S, Olabinri E, Ikubor J, Oyinloye O, Odunlami F, Akpa O, Melikam S, Saulson R, Ovbiagele B.  2017.  AIM on Clear Canvas Enriched Stroke Phenotyping Software (ACCESS).
Waschke, O, Fehse B, Kabisch H, Zander AR, Fehse N, Renges H, Kroger N, Zabelina T, Ayuk F, Schieder H, Oyekunle AA.  2006.  Allogeneic stem-cell transplantation in patients with refractory acute leukemia: a long-term follow-up, Jan. Bone Marrow Transplant. 37:45-50., Number 1 AbstractWebsite

We examined retrospectively 44 patients with refractory acute leukemia (acute myeloid leukemia (AML)/acute lymphoblastic leukemia=25/19) who underwent allogeneic transplantation at our center between 11/1990 and 04/2004. The median leukemic blasts was 25% and age 28 years (range, 3-56). Twenty-one patients had untreated relapse, 13 failed reinduction, eight in partial remission and two aplastic. Conditioning was myeloablative using cyclophosphamide, busulfan, total-body irradiation and etoposide (Bu/Cy/VP, n=22; TBI/Cy/VP, n=17; others, n=5) followed by marrow or peripheral blood transplant (n=23/21) from unrelated or related donors (n=28/16). All patients had graft-versus-host disease (GVHD) prophylaxis with cyclosporin and methotrexate. One patient experienced late graft failure. Severe acute-GVHD and chronic-GVHD appeared in eight and 14 patients, respectively. Thirteen patients (30%) remain alive after a median of 25.3 months (range, 2.4-134.1); with 31 deaths, mostly from relapse (n=15) and infections (n=12). Overall survival (OS) and progression-free survival (PFS) at 5 years was 28 and 26%, respectively. OS and PFS were significantly better with blasts < or =20% and time to transplant < or =1 year while transplant-related mortality was less with the use of TBI. We conclude that patients with refractory leukemia can benefit from allogeneic BMT, especially with < or =20% marrow blast.

Salpietro, V, Dixon CL, Guo H, Bello OD, Vandrovcova J, Efthymiou S, Maroofian R, Heimer G, Burglen L, Valence S et al..  2019.  AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders, 2019. Nature Communications. 10(1) Abstract

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission.

Sarfo, FS, Ovbiagele B, Matthew OA, Akpalu A, Wahab K, Obiako R, Owolabi L, Asowata O, Ogbole G, Komolafe M, Akinyemi R, Owolabi M.  2020.  Antecedent febrile illness and occurrence of stroke in West Africa: The SIREN study, 2020. Journal of the Neurological Sciences. 418 Abstract

Background: Acute infections have been posited as potential precipitants or triggers of the occurrence of stroke among adults with traditional vascular risk factors. We evaluated associations between stroke occurrence and reported febrile illness within 4 weeks (potential antecedent infections) among West Africans. Methods: The Stroke Investigative Research and Educational Network (SIREN) is a multicenter, case-control study involving 15 sites in Ghana and Nigeria. Cases include adults aged ≥18 years with radiologically confirmed strokes. Controls were stroke-free adults matched with cased by age, gender and ethnicity. Detailed evaluations for vascular, lifestyle and psychosocial factors were performed. Participants were asked for evidence of any febrile illness within the past 4 weeks. We used conditional logistic regression to estimate adjusted odds ratios (aOR) with 95% Confidence Interval. Results: Among 3588 stroke cases recruited in Ghana and Nigeria between August 2014 and July 2018, 363 cases (10.1%) reported having a febrile illness within the 4 weeks prior to stroke occurrence. Having an antecedent infection was associated with stroke occurrence with an unadjusted OR of 1.19 (1.00–1.51) but aOR of 0.83 (0.59–1.17) upon adjusting for traditional vascular risk factors. Stress, aOR of 4.69 (2.59–8.50) and consumption of green vegetables 2.27 (1.35–2.85) were associated with antecedent febrile illness. Conclusion: 1 in 10 stroke cases reported antecedent history of febrile illness prior to occurrence of stroke but no independent association was observed in this study. Infectious exposures may be important triggers of cardiovascular events requiring further exploratory studies to better understand the role of this emerging risk factor.

Sartelli, M, Weber DG, Ruppé E, Bassetti M, Wright BJ, Ansaloni L, Catena F, Coccolini F, Abu-Zidan FM, Coimbra R, others.  2016.  Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA). World journal of emergency surgery. 11:1–32., Number 1: Springer Abstract
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Akinyemi, R, Tiwari HK, Arnett DK, Ovbiagele B, Irvin MR, Wahab K, Sarfo F, Srinivasasainagendra V, Adeoye A, Perry RT, Akpalu A, Jenkins C, Arulogun O, Gebregziabher M, Owolabi L, Obiako R, Sanya E, Komolafe M, Fawale M, Adebayo P, Osaigbovo G, Sunmonu T, Olowoyo P, Chukwuonye I, Obiabo Y, Onoja A, Akinyemi J, Ogbole G, Melikam S, Saulson R, Owolabi M.  2018.  APOL1, CDKN2A/CDKN2B, and HDAC9 polymorphisms and small vessel ischemic stroke, 2018. Acta Neurologica Scandinavica. 137(1) Abstract

Objective: Worldwide, the highest frequencies of APOL1-associated kidney variants are found in indigenous West Africans among whom small vessel disease (SVD) ischemic stroke is the most common stroke phenotype. The objective of this study was to investigate the association and effect sizes of 23 selected SNPs in 14 genes of relevance, including the APOL1 G1 variants, with the occurrence of SVD ischemic stroke among indigenous West African participants in the Stroke Investigative Research and Education Network (SIREN) Study. Materials and Methods: Cases were consecutively recruited consenting adults (aged 18 years or older) with neuroimaging—confirmed first clinical stroke. Stroke-free controls were ascertained using a locally validated version of the Questionnaire for Verifying Stroke-Free Status (QVSFS). Logistic regression models adjusting for known vascular risk factors were fitted to assess the associations of the 23 SNPs in rigorously phenotyped cases (N = 154) of SVD ischemic stroke and stroke-free (N = 483) controls. Results: Apolipoprotein L1 (APOL1) rs73885319 (OR = 1.52; CI: 1.09-2.13, P-value =.013), rs2383207 in CDKN2A/CDKN2B (OR = 3.08; CI: 1.15-8.26, P –value =.026) and rs2107595 (OR = 1.70; CI: 1.12-2.60, P-value =.014) and rs28688791 (OR = 1.52; CI: 1.03-2.26, P-value =.036) in HDAC9 gene were associated with SVD stroke at 0.05 significance level. Polymorphisms in other genes did not show significant associations. Conclusion: This is the first report of a specific association of APOL1 with a stroke subtype. Further research is needed to confirm these initial findings and deepen understanding of the genetics of stroke in people of African ancestry with possible implications for other ancestries as all humans originated from Africa.

Atere, CT, Ge T, Zhu Z, Liu S, Huang X, Shibistova O, Guggenberger G, Wu J.  2019.  Assimilate allocation by rice and carbon stabilisation in soil: effect of water management and Phosphorus fertilisation. Plant and Soil . 445:153–167.
L.J.J, G, W.L A, M E, P.A M, T B, B A, P D, F.K.N A, S.A B, A M, M L, E.A A-A, W D, P T, O J, M D, P A, A.A O, R B, G P-R, M G, S O-Y, G.O O, P.B O, L A-R, F A, T H, P G, M.O O, C.J B, M.L M, A.A A, J.C M, A B.  2016.  Association studies and direct DNA sequencing implicate genetic susceptibility loci in the etiology of nonsyndromic orofacial clefts in sub-Saharan African populations. J Dental Research. 95(11):1245-1256.
W.B, Odetoyin, AIKAORT.  2008.  Asymptomatic bacteriuria in patients with diabetes mellitus in Ile-Ife, South-West, Nigeria.. East Africa Medical Journal Kenya. 85:18–23.: Kenya Medical Association Abstract
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W.B, Odetoyin, AIKRTBA.  2008.  Asymptomatic Bacteriuria in Patients with Diabetes Mellitus in {{Ile}}-{{Ife}}, {{South}}-{{West}}, {{Nigeria}}.. East Africa Medical Journal Kenya. 85:18–23.: {Kenya Medical Association} Abstract
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Zhu, Z, Ge T, Xiao M, Yuan H, Wang, T., Liu S, Atere CT, Wu J.  2017.  Belowground carbon allocation and dynamics under rice cultivation depends on soil organic matter content. Plant and Soil. 410:247–258.
Akinyemi, RO, Akinwande K, Diala S, Adeleye O, Ajose A, Issa K, Owusu D, Boamah I, Yahaya IS, Jimoh AO, Imoh L, Fakunle G, Akpalu A, Sarfo F, Wahab K, Sanya E, Owolabi L, Obiako R, Osaigbovo G, Komolafe M, Fawale M, Adebayo P, Olowoyo P, Obiabo Y, Sunmonu T, Chukwuonye I, Balogun O, Adeoye B, Oladele F, Olowoniyi P, Adeyemi F, Lezzi A, Falayi AT, Fasanya M, Ogunwale K, Adeola O, Olomu O, Aridegbe O, Laryea R, Uvere E, Faniyan M, Melikam E, Tagge R, Akpa O, Akinyemi J, Arulogun O, Tiwari HK, Ovbiagele B, Owolabi MO.  2018.  Biobanking in a Challenging African Environment: Unique Experience from the SIREN Project, 2018. Biopreservation and Biobanking. 16(3) Abstract

Africa was previously insufficiently represented in the emerging discipline of biobanking despite commendable early efforts. However, with the Human, Heredity, and Health in Africa (H3Africa) initiative, biorepository science has been bolstered, regional biobanks are springing up, and awareness about biobanks is growing on the continent. The Stroke Investigative Research and Educational Network (SIREN) project is a transnational, multicenter, hospital and community-based study involving over 3000 cases and 3000 controls recruited from 16 sites in Ghana and Nigeria. SIREN aims to explore and unravel the genetic and environmental factors that interact to produce the peculiar phenotypic and clinical characteristics of stroke as seen in people of African ancestry and facilitate the development of new diagnostics, therapeutics, and preventative strategies. The aim of this article is to describe our experience with the development of the procedure for collection, processing, storage, and shipment of biological samples (blood, serum, plasma, buffy coat, red cell concentrates, and DNA) and brain imaging across coordinating and participating sites within the SIREN Project. The SIREN network was initiated in 2014 with support and funding from the H3Africa Initiative. The SIREN Biobank currently has 3015 brain images, 92,950 blood fractions (serum, plasma, red cell concentrates, and buffy coat) accrued from 8450 recruited subjects, and quantified and aliquoted good-quality DNA extracts from 6150 study subjects. This represents an invaluable resource for future research with expanding genomic and trans-omic technologies. This will facilitate the involvement of indigenous African samples in cutting-edge stroke genomics and trans-omics research. It is, however, critical to effectively engage African stroke patients and community members who have contributed precious biological materials to the SIREN Biobank to generate appropriate evidence base for dealing with ethical, legal, and social issues of privacy, autonomy, identifiability, biorights, governance issues, and public understanding of stroke biobanking in the context of unique African culture, language, and belief systems.

Idowu, PA, Williams KO, Balogun JA, Oluwaranti AI.  2015.  Breast Cancer Risk Prediction Using Data Mining Classification Techniques. Transactions on Networks and Communications. 3(2):1-11.
Olagunju, A, Bolaji O, Amara A, Waitt C, Else L, Adejuyigbe E, Siccardi M, Back D, Khoo S, Owen A.  2015.  Breast milk pharmacokinetics of efavirenz and breastfed infants' exposure in genetically-defined subgroups of mother-infant pairs: an observational study. Clinical Infectious Diseases. AbstractWebsite

Background. The antiretroviral drug efavirenz is widely used during breastfeeding. Evaluating its safety requires an understanding of its breast milk pharmacokinetics, level of breastfed infants' exposure and potential influence of polymorphisms in drug disposition genes.

Methods. For this observational study, we investigated plasma and breast milk pharmacokinetics of efavirenz and breastfed infants' exposure in HIV positive nursing mothers and their breastfed infants. We also evaluated potential variability due to genetic polymorphisms in CYP2B6, NR1I3, CYP2A6, ABCB1, ABCB5 and ABCG2.

Results. CYP2B6 516G>T was independently associated with efavirenz concentrations in maternal plasma, breast milk and infant plasma (n=134). When stratified based on CYP2B6 516G>T (n=29 ; 11 GG, 10 GT and 8 TT), EFV pharmacokinetic parameters in plasma and breast milk differed significantly between patient groups. The median time averaged milk-to-plasma concentration ratio was 1.10 (range: 0.57-1.71). The estimated maximum infant efavirenz dose from breast milk was 809 µg/kg/day (215-2760) and paediatric dose weight-adjusted exposure index was 4.05% (1.08-13.8). Infant plasma concentrations did not change significantly during the dosing interval, 157 ng/mL (28.6-1360) in pooled analysis and 315 ng/mL (108-1360) in CYP2B6 516TT group. Infant plasma concentrations were highest up to 8 days of age at 1590 ng/mL (190-4631) and decreased by about 90% in the age stratum day 9 to 3 months. No efavirenz related toxicity was reported.

Conclusions. Most breastfed infants are exposed to less than 10% of the weight-adjusted therapeutic paediatric dose, the safety threshold for exposure to maternal drugs from breast milk.

Olagunju, A, Bolaji O, Amara A, Waitt C, Else L, Adejuyigbe E, Siccardi M, Back D, Khoo S, Owen A.  2015.  Breast milk pharmacokinetics of efavirenz and breastfed infants’ exposure in genetically-defined subgroups of mother-infant pairs: an observational study. Clinical Infectious Diseases. 61(3):453-63. Abstract

BACKGROUND: The antiretroviral drug efavirenz is widely used during breastfeeding. Evaluating its safety requires an understanding of its breast milk pharmacokinetics, level of breastfed infants' exposure, and potential influence of polymorphisms in drug disposition genes.

METHODS: For this observational study, we investigated plasma and breast milk pharmacokinetics of efavirenz and breastfed infants' exposure in human immunodeficiency virus positive nursing mothers and their breastfed infants. We also evaluated potential variability due to genetic polymorphisms in CYP2B6, NR1I3, CYP2A6, ABCB1, ABCB5, and ABCG2.

RESULTS: CYP2B6 516G>T was independently associated with efavirenz concentrations in maternal plasma, breast milk, and infant plasma (n = 134). When stratified based on CYP2B6 516G>T (n = 29 ; 11 GG, 10 GT and 8 TT), efavirenz pharmacokinetic parameters in plasma and breast milk differed significantly between patient groups. The median time-averaged milk-to-plasma concentration ratio was 1.10 (range: 0.57-1.71). The estimated maximum infant efavirenz dose from breast milk was 809 µg/kg/day (215-2760) and pediatric dose weight-adjusted exposure index was 4.05% (1.08-13.8). Infant plasma concentrations did not change significantly during the dosing interval, 157 ng/mL (28.6-1360) in pooled analysis and 315 ng/mL (108-1360) in CYP2B6 516TT group. Infant plasma concentrations were highest up to 8 days of age at 1590 ng/mL (190-4631) and decreased by about 90% in the age stratum day 9 to 3 months. No efavirenz related toxicity was reported.

CONCLUSIONS: Most breastfed infants are exposed to <10% of the weight-adjusted therapeutic pediatric dose, the safety threshold for exposure to maternal drugs from breast milk.

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Atere, CT, Ge T, Zhu Z, Wei L, Zhou P, He X, Kuzyakov Y, Wu J.  2018.  Carbon allocation and fate in paddy soil depending on phosphorus fertilisation and water management: results of 13C continuous labelling of rice.. Canadian Journal of Soil Science . 98(3)::469–483.
Alimi, T, Williams SB, Bamire AS, Akinrin AO.  2007.  Characteristics and trends in production and market potential of certified maize seeds in Nigeria. Lesotho Journal of Agricultural Sciences. 1(1):32-55.
WA, O, O.Adefehinti, Adelusola KA.  2010.  Childhood idiopathic steroid resistant nephrotic syndrome in southwestern Nigeria. Saudi Journal of Kidney Diseases and Transplantation. vol. 21(5):979-990..
Tiono, AB, Dicko A, Ndububa DA, Agbenyega T, Pitmang S, Awobusuyi J, Pamba A, Duparc S, Goh LE, Harrell E, Carter N, Ward SA, Greenwood B, Winstanley PA.  2009.  Chlorproguanil-Dapsone-Artesunate versus Chlorproguanil-Dapsone: A randomized, double-blind, phase III trial in African children, adolescents and adults with uncomplicated Plasmodium falciparum malaria. . American Journal of Tropical Medicine & Hygiene. 81:969–978.
Olasehinde, O, Alatise O, Omisore A, Wuraola F, Odujoko O, Romanoff A, Akinkuolie A, Arowolo O, Adisa A, Knapp G, Famurewa O, Omisile I, Onabanjo E, Constable J, Omoniyi‐Esan G, Adesunkanmi A‐R, Lawal O, Kingham T.  2021.  Contemporary management of breast cancer in Nigeria: Insights from an institutional database, 01. International Journal of Cancer. 148 Abstract
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Olasehinde, O, Alatise O, Omisore A, Wuraola F, Odujoko O, Romanoff A, Akinkuolie A, Arowolo O, Adisa A, Knapp G, others.  2021.  Contemporary management of breast cancer in Nigeria: Insights from an institutional database. International Journal of Cancer. 148:2906–2914., Number 12: Wiley Online Library Abstract
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Abdullahi, S'adT, Soyinka JO, Olagunju A, Bolarinwa RA, Olarewaju OJ, Bakare-Odunola MT, Winterberg M, Tarning J, Owen A, Khoo S.  2020.  CYP2B6* 6 Genotype Specific Differences in Artemether-Lumefantrine Disposition in Healthy Volunteers. The Journal of Clinical Pharmacology. 60:351–360., Number 3: Wiley Online Library Abstract
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Owolabi, M, Ogbole G, Akinyemi R, Salaam K, Akpa O, Mongkolwat P, Omisore A, Agunloye A, Efidi R, Odo J, Makanjuola A, Akpalu A, Sarfo F, Owolabi L, Obiako R, Wahab K, Sanya E, Adebayo P, Komolafe M, Adeoye AM, Fawale MB, Akinyemi J, Osaigbovo G, Sunmonu T, Olowoyo P, Chukwuonye I, Obiabo Y, Ibinaiye P, Dambatta A, Mensah Y, Abdul S, Olabinri E, Ikubor J, Oyinloye O, Odunlami F, Melikam E, Saulson R, Kolo P, Ogunniyi A, Ovbiagele B.  2017.  Development and Reliability of a User-Friendly Multicenter Phenotyping Application for Hemorrhagic and Ischemic Stroke, 2017. Journal of Stroke and Cerebrovascular Diseases. 26(11) Abstract

Background Annotation and Image Markup on ClearCanvas Enriched Stroke–phenotyping Software (ACCESS) is a novel stand-alone computer software application that allows the creation of simple standardized annotations for reporting brain images of all stroke types. We developed the ACCESS application and determined its inter-rater and intra-rater reliability in the Stroke Investigative Research and Educational Network (SIREN) study to assess its suitability for multicenter studies. Methods One hundred randomly selected stroke imaging reports from 5 SIREN sites were re-evaluated by 4 trained independent raters to determine the inter-rater reliability of the ACCESS (version 12.0) software for stroke phenotyping. To determine intra-rater reliability, 6 raters reviewed the same cases previously reported by them after a month of interval. Ischemic stroke was classified using the Oxfordshire Community Stroke Project (OCSP), Trial of Org 10172 in Acute Stroke Treatment (TOAST), and Atherosclerosis, Small-vessel disease, Cardiac source, Other cause (ASCO) protocols, while hemorrhagic stroke was classified using the Structural lesion, Medication, Amyloid angiopathy, Systemic disease, Hypertensive angiopathy and Undetermined (SMASH-U) protocol in ACCESS. Agreement among raters was measured with Cohen's kappa statistics. Results For primary stroke type, inter-rater agreement was.98 (95% confidence interval [CI],.94-1.00), while intra-rater agreement was 1.00 (95% CI, 1.00). For OCSP subtypes, inter-rater agreement was.97 (95% CI,.92-1.00) for the partial anterior circulation infarcts,.92 (95% CI,.76-1.00) for the total anterior circulation infarcts, and excellent for both lacunar infarcts and posterior circulation infarcts. Intra-rater agreement was.97 (.90-1.00), while inter-rater agreement was.93 (95% CI,.84-1.00) for TOAST subtypes. Inter-rater agreement ranged between.78 (cardioembolic) and.91 (large artery atherosclerotic) for ASCO subtypes and was.80 (95% CI,.56-1.00) for SMASH-U subtypes. Conclusion The ACCESS application facilitates a concordant and reproducible classification of stroke subtypes by multiple investigators, making it suitable for clinical use and multicenter research.

Owolabi, M, Ogbole G, Akinyemi R, Salaam K, Akpa O, Mongkolwat P, Omisore A, Agunloye A, Efidi R, Odo C, Makanjuola A, Akpalu A, Sarfo F, Owolabi L, Obiako R, Wahab K, Sanya E, Adebayo P, Komolafe M, Fawale M.  2017.  Development and Reliability of a User-Friendly Multicenter Phenotyping Application for Hemorrhagic and Ischemic Stroke, 07. Journal of Stroke and Cerebrovascular Diseases. 26:2662-2670. Abstract
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