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Badejoko, O, Adeyemi A, Kuti O, Ijarotimi A, Loto O, Ibraheem A, Adegoke S, Ogunniyi S.  2013.  Operative Gynecologic Laparoscopy in Ile-Ife, Nigeria: Preliminary Experience, 08. Journal of Gynecologic Surgery. 29 Abstract
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Owotade, F, Ogunbodede E, Lawal AA.  2005.  Oral Diseases in the Elderly, A Study in Ile-Ife, Nigeria, 2005/03/01. Journal of Social Sciences. 10:105-110. Abstract

To highlight oral diseases found in an elderly Nigerian population. The records of 494 elderly patients were retrospectively reviewed. The presenting complaints, relevant extraoral and intraoral findings, clinical diagnosis and investigations carried out were recorded. The ages ranged from 55 years to 120 years with almost half (44.0%) in the 60 to 69 year age group. Pain was the commonest presenting complaint (66.2%). Attrition was present in only 8% and was not related to age or sex. Coronal and root surface caries was present in 12.8% and 0.8% respectively and caries was significantly commoner in females and those who were presenting for the first time (p<0.05 and 0.01 respectively). Chronic periodontitis was the most prevalent oral disease (73.9%) and appeared to worsen with age, and decline with the state of the oral hygiene (p<0.05). Denture sore mouth was present in only females (p<0.01). Majority of the elderly (96.0%) had more than 20 teeth while only 16(3.2%) were edentulous. Squamous cell carcinoma was found in 11 patients and it affected significantly more males than females (p<0.05). Significant differences exist in the pattern of oral diseases in Nigeria when compared with the findings in other countries. Such differences might be due to socio-cultural, genetic and environmental factors.

Hernández-Ríos, P, Hernández M, Garrido M, Tervahartiala T, Leppilahti J, Kuula H, Nwhator S.  Submitted.  Oral fluid matrix metalloproteinase (MMP)-8 as a diagnostic tool in chronic periodontitis. Metalloproteinases Med. 3:11–18. Abstract
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Vidya, KM, Rao UK, Nittayananta W, Liu H, Owotade FJ.  2016.  Oral mycoses and other opportunistic infections in HIV: therapy and emerging problems - a workshop report. Oral Diseases. 22(1):158-165.
Atere, CT, Gunina A, Zhu Z, Liu S, Kuzyakov Y, Chen L, Deng Y, Wu J, Ge T.  2020.  Organic matter stabilization in aggregates and density fractions in paddy soil depending on long-term fertilization: Tracing of pathways by 13C natural abundance. Biology and Biochemistry. 149:107931.
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Adisa, AO, Lawal OO, Adesunkanmi ARK, others.  2008.  Paradox of wellness and nonadherence among Nigerian women on breast cancer chemotherapy. Journal of Cancer Research and Therapeutics. 4:107., Number 3: Medknow Publications Abstract
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AKINKUNMI, E. O., Adeyemi, O. I., Igbeneghu, O. A., Olaniyan, E. O., Omonisi, A. E., Lamikanra A.  2014.  The Pathogenicity of Staphylococcus epidermidis on the Intestinal Organs of Rats and Mice: An Experimental Investigation.. BMC Gastroenterology. 14(126)
Akinkunmi, EO, Adesunkanmi A-R, Lamikanra A.  2014.  Pattern of pathogens from surgical wound infections in a Nigerian hospital and their antimicrobial susceptibility profiles. African health sciences. 14:802–809., Number 4 Abstract
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AKINKUNMI, E. O., Adesunkanmi, A. R. K., Lamikanra A.  2014.  Pattern of Pathogens from Surgical Wound Infections in a Nigerian Hospital and their Antimicrobial Susceptibility Profiles.. African Health Sciences. 14(2):802-809.
Chelban, V, Wilson MP, Warman Chardon J, Vandrovcova J, Zanetti MN, Zamba-Papanicolaou E, Efthymiou S, Pope S, Conte MR, Abis G et al..  2019.  PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation, 2019. Annals of Neurology. 86(2) Abstract

Objective: To identify disease-causing variants in autosomal recessive axonal polyneuropathy with optic atrophy and provide targeted replacement therapy. Methods: We performed genome-wide sequencing, homozygosity mapping, and segregation analysis for novel disease-causing gene discovery. We used circular dichroism to show secondary structure changes and isothermal titration calorimetry to investigate the impact of variants on adenosine triphosphate (ATP) binding. Pathogenicity was further supported by enzymatic assays and mass spectroscopy on recombinant protein, patient-derived fibroblasts, plasma, and erythrocytes. Response to supplementation was measured with clinical validated rating scales, electrophysiology, and biochemical quantification. Results: We identified biallelic mutations in PDXK in 5 individuals from 2 unrelated families with primary axonal polyneuropathy and optic atrophy. The natural history of this disorder suggests that untreated, affected individuals become wheelchair-bound and blind. We identified conformational rearrangement in the mutant enzyme around the ATP-binding pocket. Low PDXK ATP binding resulted in decreased erythrocyte PDXK activity and low pyridoxal 5′-phosphate (PLP) concentrations. We rescued the clinical and biochemical profile with PLP supplementation in 1 family, improvement in power, pain, and fatigue contributing to patients regaining their ability to walk independently during the first year of PLP normalization. Interpretation: We show that mutations in PDXK cause autosomal recessive axonal peripheral polyneuropathy leading to disease via reduced PDXK enzymatic activity and low PLP. We show that the biochemical profile can be rescued with PLP supplementation associated with clinical improvement. As B6 is a cofactor in diverse essential biological pathways, our findings may have direct implications for neuropathies of unknown etiology characterized by reduced PLP levels. ANN NEUROL 2019;86:225–240.

Egharevba, GO, Lambi JN, Akanni MS, Jeynes C, Ajayi EOB, Adedeji AV, Eleruja MA.  2002.  Perparation and Characterization of Undoped Zinc Oxide and Uranium Doped Zinc Oxide Thin Films.. Elsevier science B.V.. Vol. 20:119-123.
Azeez, MO, Christensen JT, Ravnskov S, Heckrath GJ, Labouriau R, Christensen BT, Rubæk GH.  2020.  Phosphorus in an arable coarse sandy soil profile after 74 years with different lime and P fertilizer applications. Geoderma. 376(2020):1-10.geoderma.pdf
Waitt, C, Olagunju A, Nakalema S, Kyohaire I, Owen A, Lamorde M, Khoo S.  2018.  Plasma and breast milk pharmacokinetics of emtricitabine, tenofovir and lamivudine using dried blood and breast milk spots in nursing African mother–infant pairs. Journal of Antimicrobial Chemotherapy. AbstractDownload (Open Access)

Background: Breast milk transfer of first-line ART from mother to infant is not fully understood.

Objectives: To determine the concentrations of lamivudine, emtricitabine and tenofovir in maternal blood, breast milk and infant blood from breastfeeding mother–infant pairs.

Methods: Intensive pharmacokinetic sampling of maternal dried blood spots (DBS), dried breast milk spots (DBMS) and infant DBS from 30 Ugandan and 29 Nigerian mothers receiving first-line ART and their infants was conducted. DBS and DBMS were collected pre-dose and at 5–6 timepoints up to 12 h following observed dosing. Infant DBS were sampled twice during this period. Lamivudine, emtricitabine and tenofovir were quantified using LC-MS/MS, with non-compartmental analysis to calculate key pharmacokinetic parameters.

Results: Peak concentrations in breast milk from women taking lamivudine and emtricitabine occurred later than in plasma (4–8 h compared with 2 h for lamivudine and 2–4 h for emtricitabine). Consequently, the milk-to-plasma (M:P) ratio of lamivudine taken once daily was 0.95 (0.82–1.15) for AUC0–12, whereas for AUC12–20 this was 3.04 (2.87–4.16). Lamivudine was detectable in 36% (14/39) of infants [median 17.7 (16.3–22.7) ng/mL]. For 200 mg of emtricitabine once daily, the median M:P ratio was 3.01 (2.06–3.38). Three infants (19%) had measurable emtricitabine [median 18.5 (17.6–20.8) ng/mL]. For 300 mg of tenofovir once daily, the median M:P ratio was 0.015 (0–0.03) and no infant had measurable tenofovir concentrations.

Conclusions: Emtricitabine and lamivudine accumulate in breast milk and were detected in breastfeeding infants. In contrast, tenofovir penetrates the breast milk to a small degree, but is undetectable in breastfeeding infants.

Adegbehingbe, OO, Adetiloye AJ, Adewole L, Ajodo DU, Bello N, Esan O, Hoover AC, Ior J, Lasebikan O, Ojo O, others.  2017.  Ponseti method treatment of neglected idiopathic clubfoot: Preliminary results of a multi-center study in Nigeria. World journal of orthopedics. 8:624., Number 8: Baishideng Publishing Group Inc Abstract
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Perel, PA, Olldashi F, Muzha I, Filipi N, Lede R, Copertari P, Traverso C, Copertari A, Vergara EA, Montenegro C et al..  2008.  Predicting outcome after traumatic brain injury: Practical prognostic models based on large cohort of international patients, 2008. BMJ. 336(7641) Abstract

Objective: To develop and validate practical prognostic models for death at 14 days and for death or severe disability six months after traumatic brain injury. Design: Multivariable logistic regression to select variables that were independently associated with two patient outcomes. Two models designed: "basic" model (demographic and clinical variables only) and "CT" model (basic model plus results of computed tomography). The models were subsequently developed for high and low-middle income countries separately. Setting: Medical Research Council (MRC) CRASH Trial. Subjects: 10 008 patients with traumatic brain injury. Models externally validated in a cohort of 8509. Results: The basic model included four predictors: age, Glasgow coma scale, pupil reactivity, and the presence of major extracranial injury. The CT model also included the presence of petechial haemorrhages, obliteration of the third ventricle or basal cisterns, subarachnoid bleeding, midline shift, and non-evacuated haematoma. In the derivation sample the models showed excellent discrimination (C statistic above 0.80). The models showed good calibration graphically. The Hosmer-Lemeshow test also indicated good calibration, except for the CT model in low-middle income countries. External validation for unfavourable outcome at six months in high income countries showed that basic and CT models had good discrimination (C statistic 0.77 for both models) but poorer calibration. Conclusion: Simple prognostic models can be used to obtain valid predictions of relevant outcomes in patients with traumatic brain injury.

Adeoye, AM, Ogah OS, Ovbiagele B, Akinyemi R, Shidali V, Agyekum F, Aje A, Adebayo O, Akinyemi JO, Kolo P, Appiah LT, Iheonye H, Kelechukwu U, Ganiyu A, Olunuga TO, Akpa O, Olagoke OO, Sarfo FS, Wahab K, Olowookere S, Fakunle A, Akpalu A, Adebayo PB, Nkromah K, Yaria J, Ibinaiye P, Ogbole G, Olumayowa A, Lakoh S, Calys-Tagoe B, Olowoyo P, Innocent C, Tiwari HK, Arnett D, Godwin O, Ayotunde B, Akpalu J, Obiora O, Joseph O, Omisore A, Jenkins C, Lackland D, Owolabi L, Isah S, Dambatta AH, Komolafe M, Bock-Oruma A, Melikam ES, Imoh LC, Sunmonu T, Gebregziabher M, Olabisi O, Armstrong K, Onyeonoro UU, Sanya E, Agunloye AM, Ogunjimi L, Arulogun O, Farombi TH, Obiabo O, Obiako R, Owolabi M.  2017.  Prevalence and Prognostic Features of ECG Abnormalities in Acute Stroke: Findings From the SIREN Study Among Africans, 2017. Global Heart. 12(2) Abstract

Background Africa has a growing burden of stroke with associated high morbidity and a 3-year fatality rate of 84%. Cardiac disease contributes to stroke occurrence and outcomes, but the precise relationship of abnormalities as noted on a cheap and widely available test, the electrocardiogram (ECG), and acute stroke outcomes have not been previously characterized in Africans. Objectives The study assessed the prevalence and prognoses of various ECG abnormalities among African acute stroke patients encountered in a multisite, cross-national epidemiologic study. Methods We included 890 patients from Nigeria and Ghana with acute stroke who had 12-lead ECG recording within first 24 h of admission and stroke classified based on brain computed tomography scan or magnetic resonance imaging. Stroke severity at baseline was assessed using the Stroke Levity Scale (SLS), whereas 1-month outcome was assessed using the modified Rankin Scale (mRS). Results Patients' mean age was 58.4 ± 13.4 years, 490 were men (55%) and 400 were women (45%), 65.5% had ischemic stroke, and 85.4% had at least 1 ECG abnormality. Women were significantly more likely to have atrial fibrillation, or left ventricular hypertrophy with or without strain pattern. Compared to ischemic stroke patients, hemorrhagic stroke patients were less likely to have atrial fibrillation (1.0% vs. 6.7%; p = 0.002), but more likely to have left ventricular hypertrophy (64.4% vs. 51.4%; p = 0.004). Odds of severe disability or death at 1 month were higher with severe stroke (AOR: 2.25; 95% confidence interval: 1.44 to 3.50), or atrial enlargement (AOR: 1.45; 95% confidence interval: 1.04 to 2.02). Conclusions About 4 in 5 acute stroke patients in this African cohort had evidence of a baseline ECG abnormality, but presence of any atrial enlargement was the only independent ECG predictor of death or disability.

Windsor, HM, Abioye-Kuteyi EA, Leber JM, Morrow SD, Bulsara MK, Marshall BJ.  2005.  Prevalence of Helicobacter pylori in Indigenous Western Australians: comparison between urban and remote rural populations.. Medical Journa of Australia. 182(5):210-213.
Christianah, E, Mohammad F, Adebayo J, Lawal O, Kolawole B, Ikem R, Soyoye D.  2018.  Prevalence of Kock's diseases among diabetes patient attending state Specialist Hosital Akure South West Nigeria, 2018/11/02. Abstract
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L.J.J, G, T.D B, P.A M, M.A E, W.L A, B A, P D, F.K.N A, P A, O J, P T, R B, A.A O, G P-R, S O-Y, F A, P.E H-W, T H, J.C M, A B.  2017.  The prevalence, penetrance and expressivity of etiologic IRF6 variants in orofacial clefts patients from sub-Saharan Africa. Molecular Genetics Genomic Med.. 5(2):164-171.
Aransiola, E, Betiku E, Layokun S, Solomon B.  2010.  Production of biodiesel by transesterification of refined soybean oil. International Journal of Biological and Chemical Sciences. 4, Number 2 Abstract
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Aremu, M, Aransiola E, Layokun S, Solomon B.  2011.  Production of Polyhydroxybutyrate (PHB) by Pseudomonas Putida Strain KT2440 on Cassava Hydrolysate Medium. Res. J. Chem. Sci.. 1:67–73. Abstract
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Mosaku, KS, Fatoye FO, Komolafe M, Lawal M, Ola BA.  2006.  Quality of life and associated factors among adults with epilepsy in Nigeria, 2006. International Journal of Psychiatry in Medicine. 36(4) Abstract

Objective: Epilepsy is a common condition worldwide and has been observed to affect quality of life (QOL). Though, much has been written on this subject among western populations, little research has been done in developing countries of Africa including Nigeria. The study aims to identify factors associated with quality of life among adult epilepsy patients in this environment. Method: Respondents were evaluated using the 10-item Quality of Life in Epilepsy Inventory (QOLIE-10), the 30-item General Health Questionnaire (GHQ-30), the modified Mini Mental State Examination (mMMSE),and the Hospital Anxiety and Depression Scale (HADS). Diagnosis of epilepsy was based on clinical and electroencephalographic findings. Results: The mean age of the 51 respondents was 27.7years (SD = 9.7). Thirteen (25.5%) had an average of 2 seizure episodes in the month preceding the interview, while 37 (72.5%) have had the condition for more than 5 years. Factors that were significantly associated with overall quality of life included being female (p < 0.05), seizure frequency (p < 0.01), using more than 1 anti-epileptic drugs (AEDs) (p < 0.01), GHQ-30 score (p < 0.01), high anxiety score (p < 0.001), and high depression score p < 0.01). Multiple regression analysis showed that depressive symptoms were the single most important factor explaining low QOL. Other factors were GHQ-30 score, seizure frequency, and being a woman. Conclusion: Controlling seizures and paying attention to the psychological needs of adult epileptics will have a positive effect on the QOL among Nigerian epileptics. © 2006, Baywood Publishing Co., Inc.

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Liversidge, HM, Peariasamy K, Folayan MO, Adeniyi AA, Ngom PI, Mikami Y, Shimada Y, Kuroe K, Tvete IF, Kvaa SI.  2017.  A radiographic study of the mandibular third molar root development in different ethnic groups. Journal of Forensic Odonto-Stomatology . 35(2):103-114.
Orji, EO, Olaleye AO, Loto OM, Ogunniyi SO.  2008.  A randomised controlled trial of uterine exteriorisation and non-exteriorisation at caesarean section.. Aust N Z J Obstet Gynaecol.. 48(6):570-4.
Orji, E, Agwu F, Loto O, Olaleye O.  2008.  A randomized comparative study of prophylactic oxytocin versus ergometrine in the third stage of labor.. Int J Gynaecol Obstet. . 101(2):129-32.