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2011
Lamikanra, A, Crowe JL, Lijek RS, Odetoyin BW, Wain J, Aboderin OA, Okeke IN.  2011.  Rapid Evolution of Fluoroquinolone-Resistant {{Escherichia}} Coli in {{Nigeria}} Is Temporally Associated with Fluoroquinolone Use, dec. BMC Infectious Diseases. 11, Number 1: {BioMed Central} Abstract

Background: Antibiotic resistance has necessitated fluoroquinolone use but little is known about the selective forces and resistance trajectory in malaria-endemic settings, where selection from the antimalarial chloroquine for fluoroquinolone-resistant bacteria has been proposed. Methods: Antimicrobial resistance was studied in fecal Escherichia coli isolates in a Nigerian community. Quinolone-resistance determining regions of gyrA and parC were sequenced in nalidixic acid resistant strains and horizontally-transmitted quinolone-resistance genes were sought by PCR. Antimicrobial prescription practices were compared with antimicrobial resistance rates over a period spanning three decades. Results: Before 2005, quinolone resistance was limited to low-level nalixidic acid resistance in fewer than 4% of E. coli isolates. In 2005, the proportion of isolates demonstrating low-level quinolone resistance due to elevated efflux increased and high-level quinolone resistance and resistance to the fluoroquinolones appeared. Fluoroquinolone resistance was attributable to single nucleotide polymorphisms in quinolone target genes gyrA and/or parC. By 2009, 35 (34.5%) of isolates were quinolone non-susceptible with nine carrying gyrA and parC SNPs and six bearing identical qnrS1 alleles. The antimalarial chloroquine was heavily used throughout the entire period but E. coli with quinolone-specific resistance mechanisms were only detected in the final half decade, immediately following the introduction of the fluoroquinolone antibacterial ciprofloxacin. Conclusions: Fluoroquinolones, and not chloroquine, appear to be the selective force for fluoroquinolone-resistant fecal E. coli in this setting. Rapid evolution to resistance following fluoroquinolone introduction points the need to implement resistant containment strategies when new antibacterials are introduced into resource-poor settings with high infectious disease burdens.

Alatise, O, Lawal O, Adisa A, Arowolo O, Ayoola O, Agbakwuru A, Adesunkanmi A, Omoniyi-Esan G, Olaofe O.  2011.  Audit of Management of Gallbladder Cancer in a Nigerian Tertiary Health Facility, 2011/10/26. 43:472-80. Abstract

Gallbladder cancer is a rare malignancy with a variable incidence worldwide. It ranks number eight among all gastrointestinal cancer seen in Nigeria. It is associated with high mortality and morbidity because it is usually diagnosed very late. Adequate surgical resection is the only modality with hope of cure. This requires advanced surgical skills which is quite rare in most developing countries like Nigeria. In this current work, we audit the management and outcome of gallbladder cancer in our hospital, highlighting peculiarity associated with our setting.Consecutive patients managed as cases of gallbladder cancer at Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria between January 1990 and December 2010 were studied retrospectively. Patient demographics, disease and treatment-related variables, and outcomes were analyzed by SPSS version 16.0.
Thirty-one cases of gallbladder cancer were diagnosed over the 21-year period, and this accounts for about 0.3% of all cancer cases seen in our hospital. The median age of this patient cohort was 58 years (range 28 to 79 years). Seventeen (54.8%) patients were age below 60 while 14 (45.2%) were age 60 and above. Twenty-seven patients (87.1%) were female and four (12.9%) were male, with a male to female ratio approximately 1:7. Over 80% of the patients presented with a triad of upper abdominal pain, weight loss, and jaundice. Majority (67.7%) of the patients were diagnosed intraoperatively. Only four patients underwent complete resection as they had radical cholecystectomy including regional lymph node dissection and wedge resection of the gallbladder fossa of the liver. The stages of the resected patients were T3 in three patients and T2 in one. Overall 1- and 5-year survival rates for our entire patient cohort were 32% and 10%, respectively.
In conclusion, this study showed that preoperative diagnosis of gallbladder cancer could be challenging in our environment. A triad of upper abdominal pain, jaundice, and weight loss with judicious use of available radiological modality will increase the chances of making the preoperative diagnosis of the cancer. It also showed that good outcome can be obtained when radical surgery is offered to these few patients within the limitation of resources in few patients with resectable tumor.

Adisa, A, Lawal O, Arowolo O, Akinola D.  2011.  Laparoscopic cholecystectomy in Ile-Ife, Nigeria, 09. African journal of medicine and medical sciences. 40:221-4. Abstract
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Ligali, TO, Folayan MO, Sheiham A.  2011.  Assessment of time taken to treat dental trauma in Nigerian children . European Archives of Paediatric Dentistry . 12(1):37-40.
Abioye-Kuteyi, EA, Kuku JO, Lateef IC, Ogundipe JA, Mogbeyteren T, Banjo MA.  2011.  Birth Preparedness and Complication Readiness among pregnant women at the three levels of health facilities in Ife Central Local Government, Nigeria.. Journal of Community Medicine and Primary Health Care. . 23(1-2):41-54.
Obembe, AO, Olaogun MO, Adedoyin RA, Lamidi RE.  2011.  Determinants of Balance Performance in Hemiparetic Stroke Survivors. Turk J Phys Med Rehab. 57:201-205.
Obembe, AO, Olaogun MO, Adedoyin RA, Lamidi RE.  2011.  Determinants of Balance Performance in Hemiparetic Stroke Survivors. Turkish Journal of Physical Medicine and Rehabilitation. 57:201-205.
Larsson, KAE, Saheed SA, Gradin T, Delp G, Karpinska B, Botha CEJ, Jonsson LMV.  2011.  Differential regulation of 3-Aminomethylindole / N-Methyl-3-aminomethylindole N-methyltransferase and gramine in barley by both biotic and abiotic stress conditions. . Plant Physiology and Biochemistry . 49:96-102.larsson_et_al_2011.pdf
Lawani, AO.  2011.  The Effects of Parenting Styles on Student’s Disposition to Violence in Osun State, Nigeria. Revista de Cercetaresi Interventie Sociala. 32:86-94.
Bisi-Johnson, MA, Obi CL, Hattori T, Li S, Kambizi L, Eloff JN, Vasaikar SD.  2011.  Evaluation of the antibacterial and anticancer activities of some South African medicinal plants.. BMC Complementary and Alternative Medicine. 11:14
Akanmu, MA, Adeloye AO, Obuotor EM, Adelusola KA, Iwalewa EO, Ukponmwan OE, Lamikanra A.  2011.  Neuropharmacological effects of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae) in mice. International Journal Biol. Chem. Sci. Vol. 5(6):2250-2262.
Akanmu, MA, Olowookere TA, Atunwa SA, Ibrahim BO, Lamidi OF, Adams PA, Ajimuda BO, Adeyome LE.  2011.  Neuropharmacological effects of Nigerian Honey in Mice. African Journal Traditional complement Atern. Med.. Vol. 8(3):230-249.
Aremu, M, Aransiola E, Layokun S, Solomon B.  2011.  Production of Polyhydroxybutyrate (PHB) by Pseudomonas Putida Strain KT2440 on Cassava Hydrolysate Medium. Res. J. Chem. Sci.. 1:67–73. Abstract
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Lamikanra, A, Crowe JL, Lijek RS, Odetoyin BW, Wain J, Aboderin OA, Okeke IN.  2011.  Rapid evolution of fluoroquinolone-resistant Escherichia coli in Nigeria is temporally associated with fluoroquinolone use. BMC infectious diseases. 11:312., Number 1: BioMed Central Abstract
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2010
Arowolo, O, Akinkuolie A, Lawal O, Alatise O, Salako A, Adisa A.  2010.  The Impact of Neoadjuvant Chemotherapy on Patients with Locally Advanced Breast Cancer in a Nigerian Semiurban Teaching Hospital: A Single-center Descriptive Study, 05. World journal of surgery. 34:1771-8. Abstract
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Akanmu, MA, Adeloye AO, Obutor EM, Adelusola KA, Iwalewa EO, Ukponmwan OE, Lamikanra A.  2010.  Acute and Sub-Chronic toxicity potential effects of Alchornea Cordifolia (Euphorbiaceae) in rats. Nig. J. Nat. Prod.. 14:1-7.
Skews B.W, Muritala A.O, Lucovig L., C. L.  2010.  Large scale shock wave diffraction experiments. 29th International Congress on High-Speed Photography and Photonic.
Adisa, AO, Gukas ID, Lawal OO, Adesunkanmi ARK.  2010.  Breast cancer in Nigeria: Is non-adherence to chemotherapy schedules a major factor in the reported poor treatment outcome? The breast journal. 16:206–207., Number 2: Wiley Online Library Abstract
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Adisa, AO, Gukas ID, Lawal OO, Adesunkanmi ARK.  2010.  Breast cancer in Nigeria: Is non-adherence to chemotherapy schedules a major factor in the reported poor treatment outcome? The breast journal. 16:206–207., Number 2: Wiley Online Library Abstract
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Aransiola, E, Betiku E, Layokun S, Solomon B.  2010.  Production of biodiesel by transesterification of refined soybean oil. International Journal of Biological and Chemical Sciences. 4, Number 2 Abstract
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2009
Alatise, O, Arigbabu A, Lawal O, Adesunkanmi A, Agbakwuru A, Ndububa D, Akinola D.  2009.  Endoscopic hemorrhoidal sclerotherapy using 50% dextrose water: A preliminary report, 06. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. 28:31-2. Abstract
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Liasu A., Agunbiade O.M., BLO & AO.  2009.  Menstrual Discomfort and its Influence on Daily Academic Activities and Psychosocial Relationship among Undergraduate Female Students in Nigeria. Tanzania Journal of Health Research. 11(4):181-188.
B.E., A, L.A. A, S.O. A.  2009.  Seed germination and in vitro propagation of Piliostigma thonningii – an important medicinal plant.. African Journal of Biotechnology . Vol. 8(3):401-404.