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Lozano, R, Fullman N, Mumford J, Knight M, Barthelemy C, Cristiana A, Abbastabar H, Abd-Allah F, Abdollahi M, Abedi A, Abolhassani H, Eshete A, Guimarães Abreu L, Abrigo M, Haimed A, I. Abushouk A, Adabi M, Adebayo O, Adekanmbi V.  2020.  Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019, 2020/10/17. 396:1250-1284. Abstract
Jafarinia, M, Vos T, Lim S, Naghavi M, Murray C, Onwujekwe O, Oancea B, Aravkin A, Zheng P, Cristiana A, Abbas K, Abbasi-Kangevari M, Abd-Allah F, Abdelalim A, Abdollahi M, Abdollahpour I, Abegaz K, Abolhassani H, Aboyans V, Ghajar A.  2020.  Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019, 2020/10/16. 396:1204-1222. Abstract
Deshpande, A, Miller-Petrie M, Lindstedt P, Baumann M, Johnson K, Blacker B, Abbastabar H, Abd-Allah F, Abdelalim A, Abdollahpour I, Abegaz K, Abejie A, Guimarães Abreu L, Abrigo M, Abualhasan A, Accrombessi M, Adamu A, Adebayo O, Isaac A, Karimi S.  2020.  The global distribution of lymphatic filariasis, 2000–18: a geospatial analysis, 2020/09/01. 8:e1186-e1194. Abstract
Deshpande, A, Miller-Petrie M, Lindstedt P, Baumann M, Johnson K, Blacker B, Abbastabar H, Abd-Allah F, Abdelalim A, Abdollahpour I, Abegaz K, Abejie A, Guimarães Abreu L, Abrigo M, Abualhasan A, Accrombessi M, Adamu A, Adebayo O, Isaac A, Reiner R.  2020.  Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000–17, 2020/09/01. 8:e1162-e1185. Abstract
James, S, Castle C, Dingels Z, Fox J, Hamilton E, Liu Z, Roberts N, Sylte D, Bertolacci G, Cunningham M, Henry N, LeGrand K, Abdelalim A, Abdollahpour I, Suliankatchi R, Abedi A, Abegaz K, Eshete A, I. Abushouk A.  2020.  Estimating global injuries morbidity and mortality: Methods and data used in the Global Burden of Disease 2017 study, 2020/08/24. 26:injuryprev-2019. Abstract
Kinyoki, D, Ross J, Lazzar-Atwood A, Munro S, Schaeffer L, Abbasalizad Farhangi M, Abbasi M, Abbastabar H, Abdelalim A, Abdoli A, Abdollahi M, Abdollahpour I, Abdulkader R, Dereje N, Abebo T, Abegaz K, Abolhassani H, Guimarães Abreu L, Abrigo M, Hay S.  2020.  Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017, 2020/08/01. 26:1-1. Abstract
Wiens, K, Lindstedt P, Blacker B, Johnson K, Baumann M, Schaeffer L, Abbastabar H, Abd-Allah F, Abdelalim A, Abdollahpour I, Abegaz K, Abejie A, Guimarães Abreu L, Abrigo M, Abualhasan A, Accrombessi M, Acharya D, Adabi M, Adamu A.  2020.  Mapping geographic inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17, 2020/07/22. 8:e1038-1060. Abstract
Kinyoki, D, Ross J, Lazzar-Atwood A, Munro S, Schaeffer L, Abbasalizad Farhangi M, Abbasi M, Abbastabar H, Abdelalim A, Abdoli A, Abdollahi M, Abdollahpour I, Suliankatchi R, Dereje N, Abebo T, Abegaz K, Abolhassani H, Guimarães Abreu L, Abrigo M, Hay S.  2020.  Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017, 2020/05/01. 26:1-10. Abstract
David, R, Badmus T, Salako A, Christianah, Asaleye M, Adeloye D, Fanimi O, Opele J, Laoye A, Akinbola I, Igbokwe M, Babalola R, Chigozie, Onyeze C.  2020.  O R I G I N A L P A P E R Diagnostic performance of transrectal ultrasound for prostate volume estimation in men with benign prostate hyperplasia, 2020/01/01. :13615. Abstract

Background and Aim: Despite transrectal ultrasound (TRUS) being regarded as gold

Sarfo, FS, Ovbiagele B, Gebregziabher M, Akpa O, Akpalu A, Wahab K, Ogbole G, Akinyemi R, Obiako R, Komolafe M, Owolabi L, Lackland D, Arnett D, Tiwari H, Markus HS, Akinyemi J, Oguntade A, Fawale B, Adeoye A, Olugbo O, Ogunjimi L, Osaigbovo G, Jenkins C, Chukwuonye I, Ajose O, Oyinloye L, Mutiso F, Laryea R, Calys-Tagoe B, Salaam A, Amusa G, Olowookere S, Imoh C, Mande A, Arulogun O, Adekunle F, Appiah L, Balogun O, Singh A, Adeleye O, Ogah O, Makanjuola A, Owusu D, Kolo P, Adebayo O, Agunloye A, Shidali V, Faniyan M, Lakoh S, Diala S, Iheonye H, Efidi C, Sanya E, Sunmonu T, Akintunde A, Owolabi M.  2020.  Unraveling the risk factors for spontaneous intracerebral hemorrhage among West Africans, 2020. Neurology. 94(10) Abstract

ObjectiveTo characterize risk factors for spontaneous intracerebral hemorrhage (sICH) occurrence and severity among West Africans.MethodsThe Stroke Investigative Research and Educational Network (SIREN) study is a multicenter case-control study involving 15 sites in Ghana and Nigeria. Patients were adults ≥18 years old with CT-confirmed sICH with age-, sex-, and ethnicity-matched stroke-free community controls. Standard instruments were used to assess vascular, lifestyle, and psychosocial factors. Factors associated with sICH and its severity were assessed using conditional logistic regression to estimate odds ratios (ORs) and population-attributable risks (PARs) with 95% confidence intervals (CIs) for factors.ResultsOf 2,944 adjudicated stroke cases, 854 were intracerebral hemorrhage (ICH). Mean age of patients with ICH was 54.7 ± 13.9 years, with a male preponderance (63.1%), and 77.3% were nonlobar. Etiologic subtypes of sICH included hypertension (80.9%), structural vascular anomalies (4.0%), cerebral amyloid angiopathy (0.7%), systemic illnesses (0.5%), medication-related (0.4%), and undetermined (13.7%). Eight factors independently associated with sICH occurrence by decreasing order of PAR with their adjusted OR (95% CI) were hypertension, 66.63 (20.78-213.72); dyslipidemia, 2.95 (1.84-4.74); meat consumption, 1.55 (1.01-2.38); family history of CVD, 2.22 (1.41-3.50); nonconsumption of green vegetables, 3.61 (2.07-6.31); diabetes mellitus, 2.11 (1.29-3.46); stress, 1.68 (1.03-2.77); and current tobacco use, 14.27 (2.09-97.47). Factors associated with severe sICH using an NIH Stroke Scale score >15 with adjusted OR (95% CI) were nonconsumption of leafy green vegetables, 2.03 (1.43-2.88); systolic blood pressure for each mm Hg rise, 1.01 (1.00-1.01); presence of midline shift, 1.54 (1.11-2.13); lobar ICH, 1.72 (1.16-2.55); and supratentorial bleeds, 2.17 (1.06-4.46).ConclusionsPopulation-level control of the dominant factors will substantially mitigate the burden of sICH in West Africa.

Lynch, K, Omisore A, Atkinson T, Famurewa O, Vera J, Kingham T, Alatise O, Hricak H, Morris E, Sutton E.  2020.  Multistakeholder Needs Assessment to Inform the Development of an mHealth-Based Ultrasound-Guided Breast Biopsy Training Program in Nigeria, 11. JCO Global Oncology. 6:1813-1823. Abstract
Ijadunola, M, Olotu E, Makhele M, Audu J, Longe M, Lawal S.  2020.  Reproductive health challenges of male and female street beggars and use of reproductive health services by female street beggars in Ife-Ijesa, Nigeria, 07. The European Journal of Contraception & Reproductive Health Care. 25:1-6. Abstract
Atere, CT, Gunina A, Zhu Z, Liu S, Kuzyakov Y, Chen L, Deng Y, Wu J, Ge T.  2020.  Organic matter stabilization in aggregates and density fractions in paddy soil depending on long-term fertilization: Tracing of pathways by 13C natural abundance. Biology and Biochemistry. 149:107931.
Azeez, MO, Christensen JT, Ravnskov S, Heckrath GJ, Labouriau R, Christensen BT, Rubæk GH.  2020.  Phosphorus in an arable coarse sandy soil profile after 74 years with different lime and P fertilizer applications. Geoderma. 376(2020):1-10.geoderma.pdf
Leonald-Emeka, EL, Aransiola EF, Ibrahim TH, Oyedele JO, Gidado RM, Iloh AC, Solomon BO.  2020.  Comparative performance of different yeast strains in the production of bioethanol using simultaneous liquefaction saccharification and fermentation (SLSF). African Journal of Biotechnology. 19:858–867., Number 12: Academic Journals Abstract
Osemene, KP, Ihekoronye MR, Lamikanra A.  2020.  Knowledge, attitudes, perceptions and practices of community pharmacists about generic medicine in Nigeria. Journal of Generic Medicines. :1741134320962843.: SAGE Publications Sage UK: London, England Abstract
Mouras, F, Badri A, Maček D, Magdalenić I, Ređep NB, Li Y, Liu Y, Li H, Liang N, Terai A, others.  2020.  Survey of the Risk Management Methods, Techniques and Software Used Most Frequently in Occupational Health and Safety. Int. J. Saf. Secur. Eng. 10:149–160. Abstract
Lawal, O, Balogun M, Akintomide A, Ayoola O, Mene-Afejuku T, Ogunlade O, Okunola O, Lawal A, Akinsola A.  2019.  Carotid Intima-Media Thickness: A Surrogate Marker for Cardiovascular Disease in Chronic Kidney Disease Patients, 2019/06/01. 13:117954681985294. Abstract

Background:Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Carotid intima-media thickness (CIMT) is a measure of atherosclerotic vascular disease and considered a comprehensive picture of all alterations caused by multiple cardiovascular risk factors over time on the arterial walls. We therefore sought to determine the CIMT of the common carotid artery in patients with CKD and to evaluate the clinical pattern and prevalence of CVD in CKD patients.
A case-control study involving 100 subjects made of 50 patients with CKD stages 2 to 4 and 50 age and sex matched apparently normal individuals. Carotid intima-media thickness of the common carotid artery was considered thickened if it measured greater than 0.8 mm. All subjects had laboratory investigations, 12-lead electrocardiogram, transthoracic echocardiography, and ankle-brachial index.
The mean CIMT was higher in CKD population compared with controls (P < .001). Eighty-four percent of the study population was found to have thickened CIMT compared with 18% of controls (P < .001). Patients with CKD had significantly higher blood pressure and heart rate than controls. Cardiovascular disease was also more prevalent among patients with CKD as compared with controls. Carotid intima-media thickness positively correlated with age, blood pressure, and random blood sugar.
As CIMT was well correlated with many cardiovascular risk factors among CKD patients, it may serve as a surrogate marker for CVD and its early assessment may target patients who may need more aggressive therapy to retard the progression of kidney disease and improve outcome.

Salpietro, V, Dixon CL, Guo H, Bello OD, Vandrovcova J, Efthymiou S, Maroofian R, Heimer G, Burglen L, Valence S et al..  2019.  AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders, 2019. Nature Communications. 10(1) Abstract

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission.

Akpalu, A, Gebregziabher M, Ovbiagele B, Sarfo F, Iheonye H, Akinyemi R, Akpa O, Tiwari HK, Arnett D, Wahab K, Lackland D, Abiodun A, Ogbole G, Jenkins C, Arulogun O, Akpalu J, Obiako R, Olowoyo P, Fawale M, Komolafe M, Osaigbovo G, Obiabo Y, Chukwuonye I, Owolabi L, Adebayo P, Sunmonu T, Owolabi M.  2019.  Differential Impact of Risk Factors on Stroke Occurrence Among Men Versus Women in West Africa: The SIREN Study, 2019. Stroke. 50(4) Abstract

Background and Purpose - The interplay between sex and the dominant risk factors for stroke occurrence in sub-Saharan Africa has not been clearly delineated. We compared the effect sizes of risk factors of stroke by sex among West Africans. Methods - SIREN study (Stroke Investigative Research and Educational Networks) is a case-control study conducted at 15 sites in Ghana and Nigeria. Cases were adults aged >18 years with computerized tomography/magnetic resonance imaging confirmed stroke, and controls were age- and sex-matched stroke-free adults. Comprehensive evaluation for vascular, lifestyle, and psychosocial factors was performed using validated tools. We used conditional logistic regression to estimate odds ratios and reported risk factor specific and composite population attributable risks with 95% CIs. Results - Of the 2118 stroke cases, 1193 (56.3%) were males. The mean±SD age of males was 58.1±13.2 versus 60.15±14.53 years among females. Shared modifiable risk factors for stroke with adjusted odds ratios (95% CI) among females versus males, respectively, were hypertension [29.95 (12.49-71.77) versus 16.1 0(9.19-28.19)], dyslipidemia [2.08 (1.42-3.06) versus 1.83 (1.29-2.59)], diabetes mellitus [3.18 (2.11-4.78) versus 2.19 (1.53-3.15)], stress [2.34 (1.48-3.67) versus 1.61 (1.07-2.43)], and low consumption of green leafy vegetables [2.92 (1.89-4.50) versus 2.00 (1.33-3.00)]. However, salt intake and income were significantly different between males and females. Six modifiable factors had a combined population attributable risk of 99.1% (98.3%-99.6%) among females with 9 factors accounting for 97.2% (94.9%-98.7%) among males. Hemorrhagic stroke was more common among males (36.0%) than among females (27.6%), but stroke was less severe among males than females. Conclusions - Overall, risk factors for stroke occurrence are commonly shared by both sexes in West Africa favoring concerted interventions for stroke prevention in the region.

Adeoye, AM, Ovbiagele B, Akinyemi JO, Ogah OS, Akinyemi R, Gebregziabher M, Wahab K, Fakunle AG, Akintunde A, Adebayo O, Aje A, Tiwari HK, Arnett D, Agyekum F, Appiah LT, Amusa G, Olunuga TO, Onoja A, Sarfo FS, Akpalu A, Jenkins C, Lackland D, Owolabi L, Komolafe M, Faniyan MM, Arulogun O, Obiako R, Owolabi M.  2019.  Echocardiographic Abnormalities and Determinants of 1-Month Outcome of Stroke Among West Africans in the SIREN Study, 2019. Journal of the American Heart Association. 8(11) Abstract

Background: Little is known about the relationship between echocardiographic abnormalities and outcome among patients with acute stroke. We investigated the pattern and association of baseline echocardiographic variables with 1-month disability and mortality among patients with stroke in the SIREN (Stroke Investigative Research and Education Network) study. Methods and Results: We enrolled and followed up consecutive 1020 adult patients with acute stroke with baseline transthoracic echocardiography from west Africa. To explore the relationship between echocardiographic variables and 1-month disability (using modified Rankin scale >3) and fatality, regression models were fitted. Relative risks were computed with 95% CIs. The participants comprised 60% men with a mean age of 59.2±14.6 years. Ischemic stroke was associated with smaller aortic root diameter (30.2 versus 32.5, P=0.018) and septal (16.8 versus 19.1, P<0.001) and posterior wall thickness at systole (18.9 versus 21.5, P=0.004). Over 90% of patients with stroke had abnormal left ventricular (LV) geometry with eccentric hypertrophy predominating (56.1%). Of 13 candidate variables investigated, only baseline abnormal LV geometry (concentric hypertrophy) was weakly associated with 1-month disability (unadjusted relative risk, 1.80; 95% CI, 0.97–5.73). Severe LV systolic dysfunction was significantly associated with increased 1-month mortality (unadjusted relative risk, 3.05; 95% CI, 1.36–6.83). Conclusions: Nine of 10 patients with acute stroke had abnormal LV geometry and a third had systolic dysfunction. Severe LV systolic dysfunction was significantly associated with 1 month mortality. Larger studies are required to establish the independent effect and unravel predictive accuracy of this association.

Akinyemi, RO, Sarfo FS, Akinyemi J, Singh A, Onoja Akpa M, Akpalu A, Owolabi L, Adeoye AM, Obiako R, Wahab K, Sanya E, Komolafe M, Ogbole G, Fawale M, Adebayo P, Osaigbovo G, Sunmonu T, Olowoyo P, Chukwuonye I, Obiabo Y, Adeniji O, Fakunle G, Melikam E, Saulson R, Yaria J, Uwanruochi K, Ibinaiye P, Amusa GA, Yahaya IS, Dambatta AH, Faniyan M, Olowoniyi P, Bock-Oruma A, Joseph OC, Oguntade A, Kolo P, Laryea R, Lakoh S, Uvere E, Farombi T, Akpalu J, Oyinloye O, Appiah L, Calys-Tagoe B, Shidali V, Tabari NA, Adebayo O, Efidi R, Adeleye O, Owusu D, Ogunjimi L, Aridegbe O, Imoh CL, Sanni T, Gebreziabher M, Hemant T, Arulogun O, Ogunniyi A, Jenkins C, Owolabi M, Ovbiagele B.  2019.  Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study, 2019. International Journal of Stroke. 14(1) Abstract

Background: It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective: To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods: A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results: Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25–1.81) and a family history of stroke (OR 1.20, 1.03–1.39) while Islamic religion (OR=0.82, CI: 0.72–0.94), being currently unmarried (OR = 0.81, CI: 0.70–0.92), and alcohol use (OR = 0.78, CI: 0.67–0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03–1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65–0.96). Conclusion: To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.

Chelban, V, Wilson MP, Warman Chardon J, Vandrovcova J, Zanetti MN, Zamba-Papanicolaou E, Efthymiou S, Pope S, Conte MR, Abis G et al..  2019.  PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation, 2019. Annals of Neurology. 86(2) Abstract

Objective: To identify disease-causing variants in autosomal recessive axonal polyneuropathy with optic atrophy and provide targeted replacement therapy. Methods: We performed genome-wide sequencing, homozygosity mapping, and segregation analysis for novel disease-causing gene discovery. We used circular dichroism to show secondary structure changes and isothermal titration calorimetry to investigate the impact of variants on adenosine triphosphate (ATP) binding. Pathogenicity was further supported by enzymatic assays and mass spectroscopy on recombinant protein, patient-derived fibroblasts, plasma, and erythrocytes. Response to supplementation was measured with clinical validated rating scales, electrophysiology, and biochemical quantification. Results: We identified biallelic mutations in PDXK in 5 individuals from 2 unrelated families with primary axonal polyneuropathy and optic atrophy. The natural history of this disorder suggests that untreated, affected individuals become wheelchair-bound and blind. We identified conformational rearrangement in the mutant enzyme around the ATP-binding pocket. Low PDXK ATP binding resulted in decreased erythrocyte PDXK activity and low pyridoxal 5′-phosphate (PLP) concentrations. We rescued the clinical and biochemical profile with PLP supplementation in 1 family, improvement in power, pain, and fatigue contributing to patients regaining their ability to walk independently during the first year of PLP normalization. Interpretation: We show that mutations in PDXK cause autosomal recessive axonal peripheral polyneuropathy leading to disease via reduced PDXK enzymatic activity and low PLP. We show that the biochemical profile can be rescued with PLP supplementation associated with clinical improvement. As B6 is a cofactor in diverse essential biological pathways, our findings may have direct implications for neuropathies of unknown etiology characterized by reduced PLP levels. ANN NEUROL 2019;86:225–240.

Olowookere, S, Badmus S, Laoye O, Ijadunola M, Hassan M.  2019.  Burden of family caregivers of ophthalmic patients in a university teaching hospital in south-west Nigeria, 03. Malawi Medical Journal. 31:39-44. Abstract