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Komolafe, MA, Ogunlade O, Komolafe EO.  2007.  Stroke mortality in a teaching hospital in South Western Nigeria, 2007. Tropical Doctor. 37(3) Abstract

Stroke, a major cause of morbidity and mortality, is on the increase and with increasing mortality. Our retrospective review of all stroke admissions from 1990-2000 show that cerebrovascular disease accounted for 3.6% (293/8144) of all medical admissions; it has a case fatality rate of 45% with the majority (61%) occurring in the first week; the mean age of stroke deaths was 62 years (standard deviation-13); and severe as well as uncontrolled hypertension is the most important risk factor. Community-based programmes aimed at early detection and treatment of hypertension, in addition to screening for those with high risk factors, should be put in place. © 2007, Royal Society of Medicine Press. All rights reserved.

Komolafe, MA, Sanusi AA, Idowu AO, Balogun SA, Olorunmonteni OE, Adebowale AA, Fawale MB, Mosaku KS.  2021.  Sleep medicine in Africa: Past, present, and future, 2021. Journal of Clinical Sleep Medicine. 17(6) Abstract

Interest in sleep and sleep disorders in Africa dates back thousands of years, influenced by various cultural and religious beliefs. However, the practice of sleep medicine as a specialty has been inadequate compared to other regions of the world. The objective of this study was to explore the current status of sleep medicine in Africa vis-à-vis education, professional societies, and facilities, and to identify challenges of the specialty in the region. A literature search of major electronic databases (PubMed, Google Scholar) was done. This revealed that there is a high prevalence of sleep disorders in Africa and a significant association with epilepsy, human African trypanosomiasis, human immunodeficiency virus, and other diseases. There are 6 sleep societies in Africa located in 4 countries. Forty-one sleep laboratories were identified located in 4 countries. The challenges hindering development of sleep medicine in Africa include lack of awareness, poor funding, lack of facilities, and inadequate training.

Komolafe, MA, Komolafe EO, Olugbodi AA, Adeolu AA.  2006.  Which headache do we need to investigate?, 2006 Cephalalgia. 26(1) Abstract
Komolafe, MA, Olaogu MOB, Adebiyi AM, Obembe AO, Fawale MB, Adebowale AA.  2015.  Stroke risk factors among participants of a world stroke day awareness program in South-Western Nigeria, 2015. Nigerian Journal of Clinical Practice. 18(6) Abstract

Introduction: Stroke is a major cause of death and disability in population across the world. Hypertension is the most common stroke risk factor globally as well as in the Nigerian population, however other modifiable risk factors such as obesity are becoming increasingly prevalent due to unhealthy diets and sedentary lifestyle. Materials and Methods: We screened 224 volunteers from Ile-Ife during the 2011 and 2012 world stroke day commemorative activities. Blood pressures (BP) were measured and body mass index (BMI) was determined from weight and height measurements. The data from 40 (18%) were incomplete and were excluded from further analysis. Results: The 184 subjects eligible for analysis comprised 85 males (46.2%) and 99 females (53.8%), with a male to female ratio of 0.85:1. Their ages ranged from 16 to 95 years (mean, 53 ± 16 years). 25% of the study population had stage 1 or 2 hypertension (mean systolic blood pressure: 127 ± 27 mmHg, mean diastolic blood pressure: 78 ± 16 mmHg), while 34.8% and 14.7% were overweight and obese, respectively (mean BMI: 25.8 ± 5.0 kg/m2). Conclusion: Stroke risk factors such as hypertension and obesity were common among the participants of the world stroke day awareness program in an urban area of Nigeria. Community screening and modification of these risk factors should be intensified in order to reduce stroke morbidity and mortality.

Komolafe, MA, Komolafe EO, Sunmonu TA, Olateju SO, Asaleye CM, Adesina OA, Badmus SA.  2008.  New onset neuromyelitis optica in a young Nigerian woman with possible antiphospholipid syndrome: a case report. Journal of medical case reports. 2:1–4., Number 1: Springer Abstract
Komolafe, MA, Sunmonu TA, Afolabi OT, Komolafe EO, Fabusiwa FO, Groce N, Kett M, Disu JO, Ajiboye JK, Olaniyan SO.  2012.  The social and economic impacts of epilepsy on women in Nigeria, 2012. Epilepsy and Behavior. 24(1) Abstract

Background: Persons with epilepsy in sub-Saharan Africa experience stigma and social marginalization. There is paucity of data on the social and economic impacts of epilepsy in these patients and in particular, groups like women. We sought to determine the social and economic impacts of epilepsy on Nigerian women and especially how it affects their treatment and outcomes. Methods: We carried out a cross-sectional survey of 63 women with epilepsy (WWE) and 69 controls matched for age, social status and site of care. A structured questionnaire was used to document information on demographic characteristics, education, employment status, economic status, health care use, personal safety and perceived stigma. The data were collated and analyzed with SPSS version 15. Results: Unemployment, fewer years of formal education, lower marriage rates and higher stigma scores were more frequent among WWE than controls. Physical and sexual abuse with transactional sex was also reported among WWE. We also noted poorer environmental and housing conditions and lower mean personal and household incomes among WWE compared to the control group. Conclusion: WWE in this sample from Nigeria have worse social and economic status when compared with women with other non-stigmatized chronic medical conditions. © 2011 Elsevier Inc.

Komolafe, M, Komolafe E, Fatoye F, Adetiloye V, Asaleye M, Famurewa O, Mosaku K, Amusa Y.  2008.  Profile Of Stroke In Nigerians: A Prospective Clinical Study, 2008/08/22. 26 Abstract

Background and purpose: Stroke is a leading cause of death and neurological disability in adults, and imposes a heavy emotional and financial burden on the family and society. We carried out this study to describe the epidemiological pattern of stroke at the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife and also to describe the risk factors, the computerized tomography (CT) scan findings and the outcome of stroke in our practice setting. Methods: We prospectively studied one hundred and thirty five consecutive patients presenting to the neurology unit of the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife over a six year period (2000- 2005). The socio-demographic and clinical data as well as the CT scan findings were collected. Statistical analysis was done using SPSS version 11.0. Results: The 135 patients comprised 76 male and 59 female with a mean age of 62+ 12years. The major risk factors were hypertension and diabetes mellitus. Cerebral infarction was the most common subtype of stroke seen. The case fatality rate was 15.6% and among the survivors the outcome was poor as only 3% made full recovery. Conclusion: Stroke is still a major problem and the major predisposing factor remains uncontrolled hypertension. The case fatality was very high and there is a risk of moderate to severe neurological disability among the survivors. The utilization of CT scan is sub-optimal even when it is available because of financial constraints. CT scan is recommended for all cases of stroke for definitive diagnosis and timely as well as accurate management.

Komolafe, MA, Fatusi OA, Alatise OI, Komolafe EO, Amusa YB, Adeolu AA, Durosinmi MA.  2009.  The role of human immunodeficiency virus infection in intranuclear facial paralysis, 2009. Journal of the National Medical Association. 101(4) Abstract

Background: This study describes the pattern of idiopathic intranuclear facial palsy (facial neuropathy) and highlights the role of human immunodeficiency virus (HIVJ/AIDS in its occurrence and management. Patients and Methods: This study conducted in lle-lfe, Nigeria, assessed individuals with idiopathic facial neuropathy seen at the neurology; maxillofacial surgery; and ear, nose and throat outpatient clinics between 1994 and 2006. Results: Eighty-eight patients with idiopathic facial neuropathy were seen during the 13-year study period. Forty-six (52.3%) were males, and the age range was 15 to 76 years, with a median of 35.5 years and interquartile range of 24.5 to 54 years. The right side was affected in 59.1%, compared with 40.9% on the left side. Twenty-six patients (29.5%) were HIV positive at presentation: 16 males, 10 females; mean age for HIV-positive patients was 29.15 ± 8.12 years and 44.39 ± 18.48 years for HIV-negative patients. There was a significant relationship among the status of the patients and the severity at presentation (p =.035), treatment given (p =.019), and the occurrence of flu-like symptoms (p =.004). Conclusion: A high index of suspicion of seroconversion is essential in patients presenting with idiopathic facial neuropathy since it has implications for management. Serological testing for HIV, especially in patients at risk and those with history of recent flu-like symptoms, is recommended.

Koya, OA, Faborode MO.  2005.  Mathematical modeling of palm nut cracking based on Hertz theory. Biosystems Engineering. 91(4):471-478.
Koya, OA, Faborode MO.  2006.  The theory of palm kernel and shell separation on spnning disc.. Biosystems Engineering [formerly J. of Agrcultural Engineeing]. 95(3):405-412.
Koya, OA, Ogunsina BS, Opeyemi OO.  2011.  Deformation and dehulling of sponge gourd (Luffa aegyptica) seeds. International Journal of Food Properties. 14:432-440.
Koya, OA, Faborode MO.  2006.  Separation theory for palm kernel and shell mixture on a spinning disc. Biosystems Engineering. 95(3):405-412.
Koya, OA, Faborode MO.  2005.  Mathematical modelling of palmnut cracking based on Hertz theory.. Biosystems Engineering [formerly J. of Agrcultural Engineeing]. 91(4):471-478.
Koya, OA, Fono TR.  2009.  Palm kernel shell in the manufacture of automotive brake pad, 10-13 February. International Seminar on Harnessing Natural Resources for National Development. , Raw Materials Research & Development Council, Abuja
Kroonen, JS, Kruisselbrink AB, Briaire-de Bruijn IH, Olaofe OO, Bovée JVMG, Vertegaal ACO.  2021.  SUMOylation Is Associated with Aggressive Behavior in Chondrosarcoma of Bone, 2021. 13(15):3823.: Multidisciplinary Digital Publishing Institute Abstract
Kroonen, JS, Kruisselbrink AB, Briaire-de Bruijn IH, Olaofe OO, VMG J.  Submitted.  Supplementary Material: SUMOylation is associated with ag-gressive behavior in chondrosarcoma of bone. Abstract
Kuliya-Gwarzo, A, Ibegbulam OG, Mamman A, Raji AA, Akingbola TS, Mabayoje VO, Ocheni S, Tanko Y, Amusu OA, Akinyanju OO, Ndakotsu MA, Kassim DO, Arewa OP, Bolarinwa RAA, Olaniyi JA, Okocha CE, Akinola NO, Bamgbade OO, Adediran IA, Salawu L, Faluyi JO, Oyekunle AA, Okanny CC, Akanmu S, Halim DNK, Bazuaye GN, Enosolease ME, Nwauche CA, Ogbe OP, Wakama TT, Durosinmi MA.  2008.  The use of Imatinib mesylate (Glivec) in Nigerian patients with chronic myeloid leukemia.. Cellular Therapy and Transplantation. 1:10.3205/ctt-2008-en-000027.01., Number 2 Abstract

Objectives: To assess response and toxicity to Imatinib mesylate (Glivec) in Nigerian Patients with chronic myeloid leukemia. Methods: From August 2003 to August 2007, 98 consecutive, consenting patients, 56 (57%) males and 42 (43%) females, median age 36 years (range, 11-65 years) diagnosed with CML, irrespective of disease phase received Imatinib at a dose of 300-600mg/day at the OAU Teaching Hospitals, Nigeria. Response to therapy was assessed by clinical, haematological and cytogenetic parameters. Blood counts were checked every two weeks in the first three months of therapy. Chromosome analysis was repeated sixth monthly. Overall survival (OS) and frequency of complete or major cytogenetic remission (CCR/MCR) were evaluated. Results: Complete haematologic remission was achieved in 64% and 83% of patients at one and three months, respectively. With a median follow-up of 25 months, the rates of CCR and MCR were 59% and 35% respectively. At 12 months of follow-up, OS and progression- free survival (PFS) were 96% and 91%, respectively. Achievement of CR at six months was associated with significantly better survival (p = 0.043).Conclusions: Compared to treatment outcome with conventional chemotherapy and alpha interferon, as previously used in Nigeria, the results obtained with this regimen has established Imatinib as the first-line treatment strategy in patients with CML, as it is in other populations, with minimal morbidity.

Kumar, V, Vallipuram K, Adebajo AC, Reisch J.  1995.  2,7-dihydroxy-3-formyl-1-(3´-methyl-2´-butenyl)carbazole from Clausena lansium. Phytochemistry. 40(5):1563-1565.
Kumolalo, FO, Adagunodo ER, Odejobi OA.  2010.  Development of a Syllabicator for Yoruba Language. Proc. of OAU TekConf, September 5-8, 2010. :47-51., OAU, Ile-Ife, Nigeria Abstract
Kuta, FA, Adabara NU, Abdulsalam R.  Submitted.  EPIDEMIOLOGY OF ASTROVIRUS INFECTION AMONG CHILDREN (0 – 5YEARS) IN NIGER STATE, NIGERIA. Ife Journal of Science. 16(2)short_communication.pdf
Kuteyi, EA, Akinsola A, Ezeoma IT.  1999.   Renal disease: the need for community based screening in rural Nigeria.. African Journal of Medical Practice. 6(5):198-201.
Kuti, O, Faponle AF, Adeyemi AB, Owolabi AT.  2008.  Pain relief in labour: a randomized controlled trial comparing pentazocine with tramadol. Nepal J Obs Gynae. 3(1):14-18.