Salpietro, V, Dixon CL, Guo H, Bello OD, Vandrovcova J, Efthymiou S, Maroofian R, Heimer G, Burglen L, Valence S et al..
2019.
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders, 2019. Nature Communications. 10(1)
AbstractAMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission.
Arogundade, AB, Hammed OS, Awoyemi MO, Falade SC, Ajama OD, Olayode FA, Adebayo AS, Olabode AO.
2020.
Analysis of aeromagnetic anomalies of parts of Chad Basin, Nigeria, using high-resolution aeromagnetic data, 2020. 6(3):1545-1556.: Springer
Abstractn/a
Arogundade, AB, Hammed OS, Awoyemi MO, Falade SC, Ajama OD, Olayode FA, Adebayo AS, Olabode AO.
2020.
Analysis of aeromagnetic anomalies of parts of Chad Basin, Nigeria, using high-resolution aeromagnetic data, 2020. Modeling Earth Systems and Environment, Springer . 6(3):1545-1556.: Springer
Abstract
Sorsa, T, Gursoy UK, Nwhator SO, Hernandez M, Tervahartiala T, Leppilahti J, Gursoy M, Könönen E, Emingil G, Pussinen PJ, Mäntylä P.
Submitted.
Analysis of matrix metalloproteinases, especially MMP-8. in gingival crevicular fluid, mouthrinse and saliva for monitoring periodontal diseases. 70:142–163., Number 1
Abstractn/a
Olaniran, O, Adetuyi F, Omoya FO, Odediran S, Hassan-olajokun R, Awoyeni E, Odetoyin B, Adesina A, Awe A, Bejide R, O O, Akinyemi L, Oyetoke O, Afolayan D.
2019.
Antiplasmodial, Antipyretic, Haematological and Histological Effects of the Leaf Extracts of Moringa oleifera in Plasmodium berghei berghei Infected Mice, 04. Journal of Advances in Medicine and Medical Research. :1-13.
Abstractn/a
] 
