Publications

Export 179 results:
Sort by: Author Title Type [ Year  (Desc)]
2014
Ayanlade, A, Drake N, Howard MT.  2014.  Monitoring global and local land transformations: how can remote sensing and GIS help? Global Land . 10(1):41-45.
Folayan, MO, Brown B, Odetoyingbo M, Harrison A.  2014.  Rape in Nigeria: a silent epidemic among adolescents with implications for HIV infection. Global Health Action . 7:25583-http://dx.doi.org/10.3402/gha.v7.25583.
Folayan, MO, Odetoyingbo M, Brown B, Harrison A.  2014.  Tackling the sexual and reproductive health and rights of adolescents living with HIV/AIDS: a priority need in Nigeria . African Journal of Reproductive Health . 18(3):102-108.
Folayan, MO, Odetoyinbo M, Brown B, Harrison A.  2014.  The underserved sexual and reproductive health needs of adolescents living with HIV in Nigeria . Nigerian Journal of Health Sciences . 14:61-64.
Heidari, O, Ghuman P, Soohoo M, Davtyan M, Folayan MO, Brown B.  2014.  Using financial incentives for HIV prevention studies in diverse global contexts: a review of the literature. Nigerian Journal of Health Sciences . 14:43-55.
2013
Siccardi, M, Olagunju A, Curley P, Hobson J, Khoo S, Back D, Owen A.  2013.  Prediction of Etravirine Pharmacogenetics Using a Physiologically Based Pharmacokinetic Approach (Abstract #888), 3-6 March. 20th Conference on Retroviruses and Opportunistic Infections (CROI). , Atlanta, GA, USA Abstract

Background: Etravirine (ETV) is metabolized by CYP3A4 and CYP2C19. A known inhibitor of CYP2C19, omeprazole increases ETV exposure by 41%. Since CYP2C19*2 (rs4244285) can affect CYP2C19 expression there is the potential to alter ETV exposure. We previously showed utility of physiologically based PK (PBPK) models for predicting genetic associations and drug-drug interactions from in vitro data in the absence of clinical data. The aim of this study was to develop a PBPK model for ETV PK and predict effects of CYP2C19*2 in virtual human subjects.

Methods: A new open-source PBPK model was developed with algorithms describing covariance between demographics and organ size, hepatic metabolism, induction of metabolic enzymes, expression, and mechanisms regulating absorption and distribution. In vitro data describing chemical properties as well as absorption, distribution, metabolism, and elimination of ETV were used to simulate ETV PK at 200 mg twice daily in 200 virtual subjects. Simulated PK parameters, such as Ctrough, Cmax, and AUC were compared with observed values from the literature. The impact of CYP2C19*2 on ETV clearance was then determined by altering CYP2C19 expression in the model. All simulations were conducted using the differential equation solver Berkeley Madonna.

Results: Simulated PK variables at steady state (mean ± SD) were Ctrough (293 ± 185 ng/mL), Cmax (363 ± 207 ng/mL), and AUC (4005 ± 2364 ng/mL.h), in agreement with previous clinical PK data: Ctrough (297 ± 391 ng/mL) and AUC (4522 ± 4710 ng/mL.h). Simulated mean ETV clearance (CL/F), volume of distribution, and ka were 59 ± 31 (L/h), 14.9 ± 3.6 L/kg, and 0.17 ± 0.011 hr–1, respectively. ETV (CL/F) was predicted to be 62 ± 35, 53 ± 31, and 41 ± 28 L/h for CYP2C19 *1/*1, *1/*2 and *2/*2, respectively.

Conclusions: The IVIVE model predicted in vivo PK of ETV in individuals with different CYP2C19 genotypes. The frequency of CYP2C19*2 has a higher frequency in Asian populations which may underpin heterogeneity in ETV exposure. Mechanistic evaluation of disposition can inform PBPK models and prediction of pharmacogenetic associations. IVIVE may be particularly helpful for the rational design of novel regimens for use in stratified populations. This includes prediction of optimal dose and dosing regimen, selection of partner drugs and validation of the likely overall pharmacological effect of discrete molecular processes, all of which can and should be tested in clinical studies.

Hammed, OS, Popoola OI, Adetoyinbo AA, Awoyemi MO, Badmus GO, Ohwo OB.  2013.  Focal depth, magnitude, and frequency distribution of earthquakes along oceanic trenches, 2013. 26(2):75-82.: Springer Abstract
n/a
Owoade, OK, Fawole OG, Olise FS, Ogundele LT, Olaniyi HB, Almeida SM, Ho MD.  2013.  Characterization and Source Identification of Airborne Particulate Loadings at Receptor Site-Classes of Lagos Mega-City, Nigeria.. Journal of the Air & Waste Management Association - JAWMA. 63(9):1026-1035.
Haire, B, Folayan MO, Hankins C, Sugarman J, McCormack S, Ramjee G, Warren M.  2013.  Ethical considerations in determining standard of prevention packages for HIV prevention trials: Examining PrEP. Developing World Bioethics . 13(2):87-94doi:10.1111/dewb.12032..
Dada, AC, Ahmad A, Usup G, Heng LY, Hamid R.  2013.  High-level aminoglycoside resistance and virulence characteristics among Enterococci isolated from recreational beaches in Malaysia. Environmental Monitoring and Assessment. 185(9):7427-7443.10.1007_s10661-013-3110-x_emas_2.pdf
Taiwo, SM, Awoyemi MO, Alabi FI, Popoola AO, Hammed OS, Onyedim GC.  2013.  Hydrogeophysical Characterization of a Typical Basement Complex: A Case Study of Modomo/Eleweran Area Southwestern Nigeria.. The Pacific Journal of Science and Technology. 14(2):576-592. Abstract

n/a

Aderemi, HO, Hassan OM, Siyanbola WO, Taiwo K.  2013.  Trends in enrollment, graduation and staffing of science and technology education in Nigeria tertiary institutions: A gender participation perspective. Educational Research and Reviews. 8(21):2011-2020.: Academic Journals Abstract
n/a
Aderemi, HO, Hassan OM, Siyanbola WO, Taiwo K.  2013.  Trends in enrollment, graduation and staffing of science and technology education in Nigeria tertiary institutions: A gender participation perspective. Educational Research and Reviews. 8(21):2011-2020.: Academic Journals Abstract
n/a
Aderemi, HO, Hassan OM, Siyanbola WO, Taiwo K.  2013.  Trends in enrollment, graduation and staffing of science and technology education in Nigeria tertiary institutions: A gender participation perspective. Educational Research and Reviews. 8(21):2011-2020.: Academic Journals Abstract
n/a
Aderemi, HO, Hassan OM, Siyanbola WO, Taiwo K.  2013.  Trends in enrollment, graduation and staffing of science and technology education in Nigeria tertiary institutions: A gender participation perspective. Educational Research and Reviews. 8(21):2011-2020.: Academic Journals Abstract
n/a
2012
Heng, LY, Usup G, Ahmad A, Dada AC.  2012.  Speciation and antimicrobial resistance of Enterococci isolated from recreational beaches in Malaysia, May 18. Environ Monit Assess. AbstractWebsite

We report the first study on the occurrence of antibiotic-resistant enterococci in coastal bathing waters in Malaysia. One hundred and sixty-five enterococci isolates recovered from two popular recreational beaches in Malaysia were speciated and screened for antibiotic resistance to a total of eight antibiotics. Prevalence of Enterococcus faecalis and Enterococcus faecium was highest in both beaches. E. faecalis/E. faecium ratio was 0.384:1 and 0.375:1, respectively, for isolates from Port Dickson (PD) and Bagan Lalang (BL). Analysis of Fisher's exact test showed that association of prevalence of E. faecalis and E. faecium with considered locations was not statistically significant (p < 0.05). Chi-square test revealed significant differences (chi (2) = 82.630, df = 20, p < 0.001) in the frequency of occurrence of enterococci isolates from the considered sites. Resistance was highest to nalidixic acid (94.84 %) and least for chloramphenicol (8.38 %). One-way ANOVA using Tukey-Kramer multiple comparison test showed that resistance to ampicillin was higher in PD beach isolates than BL isolates and the difference was extremely statistically significant (p < 0.0001). Frequency of occurrence of multiple antibiotic resistance (MAR) isolates were higher for PD beach water (64.29 %) as compared to BL beach water (13.51 %), while MAR indices ranged between 0.198 and 0.48. The results suggest that samples from Port Dickson may contain MAR bacteria and that this could be due to high-risk faecal contamination from sewage discharge pipes that drain into the sea water.

Deborah, BO, Heng LY, Gires U, Asmat A, Dada AC.  2012.  Bacteriological monitoring and sustainable management of beach water quality in malaysia: problems and prospects, May. Glob J Health Sci. 4:126-38., Number 3 AbstractWebsite

Despite the growing demand of tourism in Malaysia, there are no resolute efforts to develop beaches as tourist destinations. With no incentives to monitor public beaches or to use them in a sustainable manner, they might eventually degenerate in quality as a result of influx of pollutants. This calls for concerted action plans with a view to promoting their sustainable use. The success of such plans is inevitably anchored on the availability of robust quality monitoring schemes. Although significant efforts have been channelled to collation and public disclosure of bacteriological quality data of rivers, beach water monitoring appears left out. This partly explains the dearth of published information related to beach water quality data. As part of an on-going nation-wide surveillance study on the bacteriological quality of recreational beaches, this paper draws on a situation analysis with a view to proffering recommendations that could be adapted for ensuring better beach water quality in Malaysia.

Heng, LY, Usup G, Ahmad A, Dada AC.  2012.  Virulence characteristics and antibiotic resistance among Enterococci isolated from Bagan Lalang beach, Malaysia, Jun. International Journal of Infectious Diseases. 16:E412-E412. AbstractWebsite
n/a
2011
Udoh, Awoyemi, Olaniran O, Adefusi, Hassan-Olajokun, Odetoyin B, Idowu OJ.  2011.  The {{Prevalence}} and Susceptibility Patterns of {{Beta}}-Lactamase Producing {{Staphylococcus}} Aureus at {{OAUTHC Ile}}-{{Ife}}, {{Osun}} State, jan. International journal of biological sciences. 3:98–103. Abstract
n/a
A, O, Folayan M, T O, Harris G, Ogunbodede E.  2011.  Health workers perception of hospital’s institutional structure, 2011/01/01. American Journal of Tropical Medicine and Public Health. 1:79-88. Abstract
n/a
A, O, Folayan M, T O, Harris G, Ogunbodede E.  2011.  Health workers perception of hospital’s institutional structure, 2011/01/01. American Journal of Tropical Medicine and Public Health. 1:79-88. Abstract
n/a
Morobe, IC, Mthethwa NS, Bisi-Johnson MA, Vasaikar SD, Obi CL, Oyedeji AO, Kambizi L, Eloff JN, Hattori T.  2011.  Cytotoxic effects and safety profiles of extracts of active medicinal plants from the Eastern Cape, South Africa. The Southern African Journal of Epidemiology and infection. 26(3):141.
Bisi-Johnson, MA, Obi CL, Hattori T, Li S, Kambizi L, Eloff JN, Vasaikar SD.  2011.  Evaluation of the antibacterial and anticancer activities of some South African medicinal plants.. BMC Complementary and Alternative Medicine. 11:14