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Sarker, BKD, Abdullahi SM, Hassan Z, Kabir J, Badmus S, Alam S, Rahman M, Malek MI, Mahatma M.  2019.  Outcome of trabeculectomy with Ologen versus Mitomycin C: A comparative prospective study in Bangladesh. European journal of ophthalmology. 29:183–188., Number 2: SAGE Publications Sage UK: London, England Abstract
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Hammed, OS, Awoyemi MO, Igboama WN, Badmus GO, Essien UC.  2016.  Pattern of seismicity associated with the African lithospheric plate, 2016. :1-11. Abstract
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Chelban, V, Wilson MP, Warman Chardon J, Vandrovcova J, Zanetti MN, Zamba-Papanicolaou E, Efthymiou S, Pope S, Conte MR, Abis G et al..  2019.  PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation, 2019. Annals of Neurology. 86(2) Abstract

Objective: To identify disease-causing variants in autosomal recessive axonal polyneuropathy with optic atrophy and provide targeted replacement therapy. Methods: We performed genome-wide sequencing, homozygosity mapping, and segregation analysis for novel disease-causing gene discovery. We used circular dichroism to show secondary structure changes and isothermal titration calorimetry to investigate the impact of variants on adenosine triphosphate (ATP) binding. Pathogenicity was further supported by enzymatic assays and mass spectroscopy on recombinant protein, patient-derived fibroblasts, plasma, and erythrocytes. Response to supplementation was measured with clinical validated rating scales, electrophysiology, and biochemical quantification. Results: We identified biallelic mutations in PDXK in 5 individuals from 2 unrelated families with primary axonal polyneuropathy and optic atrophy. The natural history of this disorder suggests that untreated, affected individuals become wheelchair-bound and blind. We identified conformational rearrangement in the mutant enzyme around the ATP-binding pocket. Low PDXK ATP binding resulted in decreased erythrocyte PDXK activity and low pyridoxal 5′-phosphate (PLP) concentrations. We rescued the clinical and biochemical profile with PLP supplementation in 1 family, improvement in power, pain, and fatigue contributing to patients regaining their ability to walk independently during the first year of PLP normalization. Interpretation: We show that mutations in PDXK cause autosomal recessive axonal peripheral polyneuropathy leading to disease via reduced PDXK enzymatic activity and low PLP. We show that the biochemical profile can be rescued with PLP supplementation associated with clinical improvement. As B6 is a cofactor in diverse essential biological pathways, our findings may have direct implications for neuropathies of unknown etiology characterized by reduced PLP levels. ANN NEUROL 2019;86:225–240.

Hammed, OS, Popoola OI, Adetoyinbo AA, Awoyemi MO, Adagunodo TA, Olubosede O, Bello AK.  2018.  Peak particle velocity data acquisition for monitoring blast induced earthquakes in quarry sites, 2018. 19:398-408.: Elsevier Abstract
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Ammar, N, M. Aly N, Folayan M, Khader Y, Mohebbi S, Attia S, Howaldt H-P, Böttger S, Virtanen J, Madi M, Maharani D, Rahardjo A, Khan I, Al-Batayneh O, Rashwan M, Pavlić V, Cicmil S, Noritake K, Galluccio G, El Tantawi M.  2021.  Perceived Preparedness of Dental Academic Institutions to Cope with the COVID-19 Pandemic: A Multi-Country Survey, 2021/02/04. 18:1445. Abstract
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Räisänen, I, Umeizudike K, pirjo Parnanen, Heikkila P, Tervahartiala T, Nwhator S, Grigoriadis A, Sakellari D, Sorsa T.  2020.  Periodontal disease and targeted prevention using aMMP-8 point-of-care oral fluid analytics in the COVID-19 era, 2020/09/22. 144:1-6. Abstract
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Azeez, MO, Christensen JT, Ravnskov S, Heckrath GJ, Labouriau R, Christensen BT, Rubæk GH.  2020.  Phosphorus in an arable coarse sandy soil profile after 74 years with different lime and P fertilizer applications. Geoderma. 376(2020):1-10.geoderma.pdf
Heikkinen, A, Nwhator S, Rathnayake N, Mäntylä P, Vatanen P, Sorsa T.  2015.  A Pilot Study on Oral Health Status as Assessed by An Active Matrix Metalloproteinase-8 (aMMP-8) Chair-Side Mouthrinse Test in Adolescents, 2015/08/14. 87 Abstract
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Hassan, IA, Adegbola AJ, Soyinka JO, Onyeji CO, Bolaji OO.  2020.  Post-Marketing Surveillance of Quality of Artemether Injection Marketed in Southwest Nigeria. The American Journal of Tropical Medicine and Hygiene. 103(3):1258.: The American Society of Tropical Medicine and Hygiene Abstract
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Perel, PA, Olldashi F, Muzha I, Filipi N, Lede R, Copertari P, Traverso C, Copertari A, Vergara EA, Montenegro C et al..  2008.  Predicting outcome after traumatic brain injury: Practical prognostic models based on large cohort of international patients, 2008. BMJ. 336(7641) Abstract

Objective: To develop and validate practical prognostic models for death at 14 days and for death or severe disability six months after traumatic brain injury. Design: Multivariable logistic regression to select variables that were independently associated with two patient outcomes. Two models designed: "basic" model (demographic and clinical variables only) and "CT" model (basic model plus results of computed tomography). The models were subsequently developed for high and low-middle income countries separately. Setting: Medical Research Council (MRC) CRASH Trial. Subjects: 10 008 patients with traumatic brain injury. Models externally validated in a cohort of 8509. Results: The basic model included four predictors: age, Glasgow coma scale, pupil reactivity, and the presence of major extracranial injury. The CT model also included the presence of petechial haemorrhages, obliteration of the third ventricle or basal cisterns, subarachnoid bleeding, midline shift, and non-evacuated haematoma. In the derivation sample the models showed excellent discrimination (C statistic above 0.80). The models showed good calibration graphically. The Hosmer-Lemeshow test also indicated good calibration, except for the CT model in low-middle income countries. External validation for unfavourable outcome at six months in high income countries showed that basic and CT models had good discrimination (C statistic 0.77 for both models) but poorer calibration. Conclusion: Simple prognostic models can be used to obtain valid predictions of relevant outcomes in patients with traumatic brain injury.

Siccardi, M, Olagunju A, Curley P, Hobson J, Khoo S, Back D, Owen A.  2013.  Prediction of Etravirine Pharmacogenetics Using a Physiologically Based Pharmacokinetic Approach (Abstract #888), 3-6 March. 20th Conference on Retroviruses and Opportunistic Infections (CROI). , Atlanta, GA, USA Abstract

Background: Etravirine (ETV) is metabolized by CYP3A4 and CYP2C19. A known inhibitor of CYP2C19, omeprazole increases ETV exposure by 41%. Since CYP2C19*2 (rs4244285) can affect CYP2C19 expression there is the potential to alter ETV exposure. We previously showed utility of physiologically based PK (PBPK) models for predicting genetic associations and drug-drug interactions from in vitro data in the absence of clinical data. The aim of this study was to develop a PBPK model for ETV PK and predict effects of CYP2C19*2 in virtual human subjects.

Methods: A new open-source PBPK model was developed with algorithms describing covariance between demographics and organ size, hepatic metabolism, induction of metabolic enzymes, expression, and mechanisms regulating absorption and distribution. In vitro data describing chemical properties as well as absorption, distribution, metabolism, and elimination of ETV were used to simulate ETV PK at 200 mg twice daily in 200 virtual subjects. Simulated PK parameters, such as Ctrough, Cmax, and AUC were compared with observed values from the literature. The impact of CYP2C19*2 on ETV clearance was then determined by altering CYP2C19 expression in the model. All simulations were conducted using the differential equation solver Berkeley Madonna.

Results: Simulated PK variables at steady state (mean ± SD) were Ctrough (293 ± 185 ng/mL), Cmax (363 ± 207 ng/mL), and AUC (4005 ± 2364 ng/mL.h), in agreement with previous clinical PK data: Ctrough (297 ± 391 ng/mL) and AUC (4522 ± 4710 ng/mL.h). Simulated mean ETV clearance (CL/F), volume of distribution, and ka were 59 ± 31 (L/h), 14.9 ± 3.6 L/kg, and 0.17 ± 0.011 hr–1, respectively. ETV (CL/F) was predicted to be 62 ± 35, 53 ± 31, and 41 ± 28 L/h for CYP2C19 *1/*1, *1/*2 and *2/*2, respectively.

Conclusions: The IVIVE model predicted in vivo PK of ETV in individuals with different CYP2C19 genotypes. The frequency of CYP2C19*2 has a higher frequency in Asian populations which may underpin heterogeneity in ETV exposure. Mechanistic evaluation of disposition can inform PBPK models and prediction of pharmacogenetic associations. IVIVE may be particularly helpful for the rational design of novel regimens for use in stratified populations. This includes prediction of optimal dose and dosing regimen, selection of partner drugs and validation of the likely overall pharmacological effect of discrete molecular processes, all of which can and should be tested in clinical studies.

Folayan, MO, Haire B.  2015.  Prioritization of healthcare workers for experimental Ebola therapeutic would exacerbate existing inequalities. . Developing World Bioethics. 15(2):113-4.doi:10.1111/dewb.12083.
Folayan, MO, Caceres C, Sam-Agudu N, Odetoyinbo M, Stockman J, Harrison A.  2016.  Psychological stressors and coping strategies of adolescents living with and without HIV infection in Nigeria . AIDS and Behaviour . 21(9):2736-2745.doi:10.1007/s10461-016-1534-3..
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xiv Siyanbola, Isola O, Hassan O, Ogundari I, Awoleye M, Adesina F, Ilori M.  2010.  R&D productivity and collaborations in selected Nigerian universities., 2010/06/10. Abstract
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xiv Siyanbola, Isola O, Hassan O, Ogundari I, Awoleye M, Adesina F, Ilori M.  2010.  R&D productivity and collaborations in selected Nigerian universities., 2010/10/20. Abstract

Research and development (R&D) is a significant component of quality higher education. This is quite understandable and appreciable because R&D, most especially in Science and Technology (S&T), has become the most enduring and effective means of improving sustainable economic growth, development and re-enforcing competitiveness in industries in a rapidly changing world. Universities are widely regarded not only as teaching establishments but also as organisations that create new knowledge and innovation through research. Many academics are of the opinion that doing research improves their teaching (Colbeck, 1998, 2002; Gamson, 1995; Stevans and Reingold, 2000; Robertson and Bond, 2001; Wenzel, 2001; Winkler, 1992a, b; Woolcock, 1997; Zamorski, 2002; in Begum, 2006). In recent times, universities often use evidence of research excellenceto employ or promote staff. The main claim of the teachers and administrators are that research activity can and does serve as an important mode of teaching and a valuable means of learning and thus research is a strong condition for teaching.R&D is one of the main thrusts of activities of western universities. The developed nations have clearly demonstrated that one of the most potent means of achieving developmental goals is effective building of capability in Research and Development. They have also demonstrated the relevance of effective collaboration to sustainable scientific and technological advancement (Boozeman and Lee, 2003). To corroborate this, Ehikhamenor (2003) opined that scientific productivity, in the form of intellectual contributions to the advancement of S&T, is a fundamental consideration in the scientific enterprise. A crucial requirement for
productivity and development in S&T is a system of communication among scientists and the dissemination of scientific information. Productive R&D is expected to lead to new product(s) development or improvement of existing product(s), new process development or improvement of existing process, patents, copyrights and publications. Scientific publication is a sign of good quality of invention and research outputs. Patents, copyrights, and funds from companies are signs that those inventions have market potentials (Carneiro, 2000; Werner and Souder, 1997; in Numprasertchai and Igel, 2005). Tangible R&D outcomes should promote the link between academia and the industry. However, many private and public organizations in Nigeria are skeptical about R&D outcomes from the universities and in many cases the needs of these organisations are not met. These invariably have further widened the gap between universities and industries (Oyebisi et al., 1996).
Many studies on research productivity and collaborations include an underlining assumption that collaborative activities increase research productivity (Duque et al., 2005). However, there is a dearth of information on the validity of this proposition in Nigeria. Are Nigerian researchers collaborating for R&D among themselves and with others outside their institutions? What factors inhibit collaboration activities of researchers? What influence do researchers’ collaborations have on their R&D productivity? These are some of the pertinent questions addressed in this study. For the survey, 457 copies of questionnaire were randomly distributed among lecturers. 274 of these were returned and found useful (60% response rate). The field respondents were from Faculties of Agriculture (30.8%), Science (38.8%) and Engineering/Technology (30.4%). In assessing R&D productivity of researchers we adopt the partial productivity approach. Researchers’ publications were used as output and the number of years spent to produce the publications as input (in this study 5 years, (2004 – 2008)). The normal count (of output), which is the most frequently used approach, is adopted. The outcome of the study indicated a positive relationship between R&D productivity and collaboration. This is in agreement with some previous studies on the subject of research productivity and collaboration (Lee and Bozeman, 2005; Landry et al., 1996; Harman, 1999; in Rijnsoever et al., 2008, Walsh and Maloney, 2003; in Duque et. al., (2005)

Sartelli, M, Kluger Y, Ansaloni L, Hardcastle TC, Rello J, Watkins RR, Bassetti M, Giamarellou E, Coccolini F, Abu-Zidan FM, others.  2018.  Raising concerns about the Sepsis-3 definitions. World Journal of Emergency Surgery. 13:1–9., Number 1: BioMed Central Abstract
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Folayan, MO, Brown B, Odetoyingbo M, Harrison A.  2014.  Rape in Nigeria: a silent epidemic among adolescents with implications for HIV infection. Global Health Action . 7:25583-http://dx.doi.org/10.3402/gha.v7.25583.
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Folayan, MO, Haire BG, Adeniyi AA, Adeyemo WL.  2018.  Screening children for caries: an ethical dilemma in Nigeria. New Bioethics . 1-15:doi:10.1080/20502877.2018.1448251.
Adjalle, R, Zabelina T, Wolschke C, Zander AR, Bacher U, Held K, Arps S, Oyekunle A, Kroger N, Ayuk F, Klyuchnikov E, Ocheni S.  2011.  Second Allogeneic Stem Cell Transplantation in a Patient with Hypoplastic Myelodysplastic Syndrome following a Primary Diagnosis of Aplastic Anaemia. Acta Haematol. 125:175-178. AbstractWebsite
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Akanmu, MA, Honda K.  2005.  Selective stimulation of orexin receptor type 2 promotes wakefulness in freely behaving rats . Journal of Brain research. 1048:138-145.
Fawole, OG, Owoade OK, Hopke PK, Olise FS, Ogundele LT, Adewole OO.  2016.  Source apportionment analyses for fine (PM2.5) and coarse (PM2.5e10) mode particulate matter (PM) measured in an urban area in southwestern Nigeria. Atmospheric Pollution Research. 7:1-15.
Heng, LY, Usup G, Ahmad A, Dada AC.  2012.  Speciation and antimicrobial resistance of Enterococci isolated from recreational beaches in Malaysia, May 18. Environ Monit Assess. AbstractWebsite

We report the first study on the occurrence of antibiotic-resistant enterococci in coastal bathing waters in Malaysia. One hundred and sixty-five enterococci isolates recovered from two popular recreational beaches in Malaysia were speciated and screened for antibiotic resistance to a total of eight antibiotics. Prevalence of Enterococcus faecalis and Enterococcus faecium was highest in both beaches. E. faecalis/E. faecium ratio was 0.384:1 and 0.375:1, respectively, for isolates from Port Dickson (PD) and Bagan Lalang (BL). Analysis of Fisher's exact test showed that association of prevalence of E. faecalis and E. faecium with considered locations was not statistically significant (p < 0.05). Chi-square test revealed significant differences (chi (2) = 82.630, df = 20, p < 0.001) in the frequency of occurrence of enterococci isolates from the considered sites. Resistance was highest to nalidixic acid (94.84 %) and least for chloramphenicol (8.38 %). One-way ANOVA using Tukey-Kramer multiple comparison test showed that resistance to ampicillin was higher in PD beach isolates than BL isolates and the difference was extremely statistically significant (p < 0.0001). Frequency of occurrence of multiple antibiotic resistance (MAR) isolates were higher for PD beach water (64.29 %) as compared to BL beach water (13.51 %), while MAR indices ranged between 0.198 and 0.48. The results suggest that samples from Port Dickson may contain MAR bacteria and that this could be due to high-risk faecal contamination from sewage discharge pipes that drain into the sea water.

Folayan, MO, Haire B, Peterson K, Yakubu A, Brown B.  2015.  Stakeholder engagement with Ebola therapy research in resource limited setting. BMC Infectious Disease. 15(1):242.doi:10.1186/s12879-015-0950-8.