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Journal Article
Salpietro, V, Dixon CL, Guo H, Bello OD, Vandrovcova J, Efthymiou S, Maroofian R, Heimer G, Burglen L, Valence S et al..  2019.  AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders, 2019. Nature Communications. 10(1) Abstract

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission.

Hammed, OS, Adagunodo TA, Awoyemi MO, Arogundade AB, Ajama OD, Sapele FO, Usikalu MR, Olanrewaju AM, Akinwumi SA, Ogunwale EI.  2019.  Identification of tsunamigenic earthquake zones in oceanic ridges and trenches, 2019. 38(2):103. Abstract
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Hammed, OS, Adagunodo TA, Awoyemi MO, Arogundade AB, Ajama OD, Sapele FO, Usikalu MR, Olanrewaju AM, Akinwumi SA, Ogunwale EI.  2019.  Identification of tsunamigenic earthquake zones in oceanic ridges and trenches, 2019. 38(2):103. Abstract
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Akinyemi, RO, Sarfo FS, Akinyemi J, Singh A, Onoja Akpa M, Akpalu A, Owolabi L, Adeoye AM, Obiako R, Wahab K, Sanya E, Komolafe M, Ogbole G, Fawale M, Adebayo P, Osaigbovo G, Sunmonu T, Olowoyo P, Chukwuonye I, Obiabo Y, Adeniji O, Fakunle G, Melikam E, Saulson R, Yaria J, Uwanruochi K, Ibinaiye P, Amusa GA, Yahaya IS, Dambatta AH, Faniyan M, Olowoniyi P, Bock-Oruma A, Joseph OC, Oguntade A, Kolo P, Laryea R, Lakoh S, Uvere E, Farombi T, Akpalu J, Oyinloye O, Appiah L, Calys-Tagoe B, Shidali V, Tabari NA, Adebayo O, Efidi R, Adeleye O, Owusu D, Ogunjimi L, Aridegbe O, Imoh CL, Sanni T, Gebreziabher M, Hemant T, Arulogun O, Ogunniyi A, Jenkins C, Owolabi M, Ovbiagele B.  2019.  Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study, 2019. International Journal of Stroke. 14(1) Abstract

Background: It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective: To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods: A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results: Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25–1.81) and a family history of stroke (OR 1.20, 1.03–1.39) while Islamic religion (OR=0.82, CI: 0.72–0.94), being currently unmarried (OR = 0.81, CI: 0.70–0.92), and alcohol use (OR = 0.78, CI: 0.67–0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03–1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65–0.96). Conclusion: To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.

Chelban, V, Wilson MP, Warman Chardon J, Vandrovcova J, Zanetti MN, Zamba-Papanicolaou E, Efthymiou S, Pope S, Conte MR, Abis G et al..  2019.  PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation, 2019. Annals of Neurology. 86(2) Abstract

Objective: To identify disease-causing variants in autosomal recessive axonal polyneuropathy with optic atrophy and provide targeted replacement therapy. Methods: We performed genome-wide sequencing, homozygosity mapping, and segregation analysis for novel disease-causing gene discovery. We used circular dichroism to show secondary structure changes and isothermal titration calorimetry to investigate the impact of variants on adenosine triphosphate (ATP) binding. Pathogenicity was further supported by enzymatic assays and mass spectroscopy on recombinant protein, patient-derived fibroblasts, plasma, and erythrocytes. Response to supplementation was measured with clinical validated rating scales, electrophysiology, and biochemical quantification. Results: We identified biallelic mutations in PDXK in 5 individuals from 2 unrelated families with primary axonal polyneuropathy and optic atrophy. The natural history of this disorder suggests that untreated, affected individuals become wheelchair-bound and blind. We identified conformational rearrangement in the mutant enzyme around the ATP-binding pocket. Low PDXK ATP binding resulted in decreased erythrocyte PDXK activity and low pyridoxal 5′-phosphate (PLP) concentrations. We rescued the clinical and biochemical profile with PLP supplementation in 1 family, improvement in power, pain, and fatigue contributing to patients regaining their ability to walk independently during the first year of PLP normalization. Interpretation: We show that mutations in PDXK cause autosomal recessive axonal peripheral polyneuropathy leading to disease via reduced PDXK enzymatic activity and low PLP. We show that the biochemical profile can be rescued with PLP supplementation associated with clinical improvement. As B6 is a cofactor in diverse essential biological pathways, our findings may have direct implications for neuropathies of unknown etiology characterized by reduced PLP levels. ANN NEUROL 2019;86:225–240.

Olaniran, O, Adetuyi F, Omoya FO, Odediran S, Hassan-olajokun R, Awoyeni E, Odetoyin B, Adesina A, Awe A, Bejide R, O O, Akinyemi L, Oyetoke O, Afolayan D.  2019.  Antiplasmodial, Antipyretic, Haematological and Histological Effects of the Leaf Extracts of Moringa oleifera in Plasmodium berghei berghei Infected Mice, 04. Journal of Advances in Medicine and Medical Research. :1-13. Abstract
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Olowookere, S, Badmus S, Laoye O, Ijadunola M, Hassan M.  2019.  Burden of family caregivers of ophthalmic patients in a university teaching hospital in south-west Nigeria, 03. Malawi Medical Journal. 31:39-44. Abstract
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Atere, CT, Ge T, Zhu Z, Liu S, Huang X, Shibistova O, Guggenberger G, Wu J.  2019.  Assimilate allocation by rice and carbon stabilisation in soil: effect of water management and Phosphorus fertilisation. Plant and Soil . 445:153–167.
Sarker, BKD, Helen G, Malek MIA, Sadiq A, Hassan Z, Kabir J, Badmus S, Sazzad I, Rahman M, Mahatma M, others.  2019.  Choroidal detachment with exudative retinal detachment following Ahmed valve implantation in Sturge-Weber syndrome. GMS ophthalmology cases. 9: German Medical Science Abstract
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Sarker, BKD, Abdullahi SM, Hassan Z, Kabir J, Badmus S, Alam S, Rahman M, Malek MI, Mahatma M.  2019.  Outcome of trabeculectomy with Ologen versus Mitomycin C: A comparative prospective study in Bangladesh. European journal of ophthalmology. 29:183–188., Number 2: SAGE Publications Sage UK: London, England Abstract
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Aluko, OO, Oloruntoba EO, Chukwunenye UA, Henry EU, Ojogun E.  2018.  {The dynamics and determinants of household shared sanitation cleanliness in a heterogeneous urban settlement in Southwest Nigeria}, dec. Public Health. 165:125–135.: Elsevier AbstractWebsite

Objectives: The study assessed the behavioural contexts of household shared sanitation (SS), the factors that could enhance its cleanliness and sustainable maintenance in the study area. Study design: The study design was cross-sectional in nature. Methods: A pretested, interviewer-administered questionnaire with 113 questions provided information on knowledge, attitude and SS maintenance practices from 312 respondents selected through a four-stage sampling technique. Data were analysed by descriptive, chi-square and logistic regression statistics with attitude and toilet cleanliness as the dependent variables, while the sociodemographic characteristics, knowledge and practice, including the toilet cleanliness index, were the explanatory variables at P < 0.05. Results: The mean age of respondents was 46.1 ± 16.4 years. The majority were women (62.7%), tenants (64.7%) and had a secondary education (61.3%). In addition, 27.9% and 2.7% of respondents had shops and gender-segregated SS, respectively. Their knowledge and attitudes were good (66.3%) and positive (72.1%), while the majority (60.3%) of the SS was dirty. Almost two-thirds (62.8%) and 37.2% of respondents, respectively, had one and two or more compartments of unimproved pit toilets (31.6%) and water closets (28.6%), while 1.4% practiced open defaecation, despite having SS. More than two-fifths of SS were cleaned daily (45.4%) by women (52%), using water and soap (33.4%). Most households (93.4%) complied with the SS cleaning routines, with non-compliance attributed to lack of interest (29.5%), apathy when others defaulted (27.9%), lack of time (26.2%) and inadequate water (14.8%). There was a significant association between attitudes and education (P = 0.025), wealth (P = 0.011) and toilet-cleaning frequency (P = 0.015). The positive behaviour determinants of SS are factual knowledge (P = 0.039), efforts required to clean (P = 0.019), the ability to remember (P = 0.011) and cleaning commitment (P = 0.040), while freedom of expression among households using SS was a positive predictor of avoiding conflict, among the social dilemma factors. Conclusions: Good knowledge and positive attitudes were reported among users of SS, although with mixed practice and behaviour patterns. Factual knowledge, cleaning commitments and freedom of expressions predict SS cleanliness, which should be reinforced using periodic messages and structured health promotion strategies.

Awoyemi, MO, Ajama OD, Hammed OS, Arogundade AB, Falade SC.  2018.  Geophysical mapping of buried faults in parts of Bida Basin, North Central Nigeria, 2018. 66(S1):40-54.: Wiley Online Library Abstract
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Awoyemi, MO, Ajama OD, Hammed OS, Arogundade AB, Falade SC.  2018.  Geophysical mapping of buried faults in parts of Bida Basin, North Central Nigeria, 2018. 66(S1):40-54.: Wiley Online Library Abstract
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Hammed, OS, Awoyemi MO, Igboama WN, Fatoba JO, Bayode JO, Olurin OT, Arogundade AB, Falade SC, Aroyehun M.  2018.  Ground Magnetic Attributes For Subsurface Structural Analysis of Foundation Beds in a Sedimentary Terrain in Southwestern Nigeria: OSUSTECH Permanent Site as a case study, 2018. 3(1) Abstract
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Hammed, OS, Awoyemi MO, Igboama WN, Fatoba JO, Bayode JO, Olurin OT, Arogundade AB, Falade SC, Aroyehun M.  2018.  Ground Magnetic Attributes For Subsurface Structural Analysis of Foundation Beds in a Sedimentary Terrain in Southwestern Nigeria: OSUSTECH Permanent Site as a case study, 2018. 3(1) Abstract
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Hammed, OS, Popoola OI, Adetoyinbo AA, Awoyemi MO, Adagunodo TA, Olubosede O, Bello AK.  2018.  Peak particle velocity data acquisition for monitoring blast induced earthquakes in quarry sites, 2018. 19:398-408.: Elsevier Abstract
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Folayan, MO, Haire B, Allman D, Yakubu A, MO A.  2018.   Research priorities during infectious disease emergencies in West Africa . BMC Research Notes . 11(1):159.doi:10.1186/s13104-018-3263-3.
Atere, CT, Ge T, Zhu Z, Wei L, Zhou P, He X, Kuzyakov Y, Wu J.  2018.  Carbon allocation and fate in paddy soil depending on phosphorus fertilisation and water management: results of 13C continuous labelling of rice.. Canadian Journal of Soil Science . 98(3)::469–483.
Folayan, MO, Allman D, Haire B, Yakubu A, Afolabi MO, Cooper J.  2018.  Considerations for community engagement when conducting clinical trials during infectious disease emergencies in West Africa. Developing World Bioeth. 2018:1-10.
Olurin, OT, Ganiyu SA, Hammed OS, Alabi AA, Awoyemi MO, Coker JO.  2018.  Estimation of heat flow from spectral analysis of high resolution airborne magnetic data in Ilesha and its environs, Southwest Nigeria. Petroleum and Coal . 60(6):1336-1345. Abstract

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M.A., E, H. L, M. L, W.L. A, L.J.J. G, P.A. M, T. B, W. D, P. D, P.B. O, B.S. A, R.O. B, G.O. O, F. O, R. A, C. O, O. J, E. A-A, L.A. R, M.O. O, F.K.N A, Bello S.A., P. A, P. T, F. A, T. H, Y. D, A. H, G. P-R, S. O-Y, M.M. D, P.E. G, M.L. M, A.A. A, J.C M, R.A. C, A. B.  2018.  Loss-of-function GRHL3 variants detected in African patients with isolated cleft palate.. J Dent Res. 97(1 ):41–48.p22_-_eshete_et_al._2018-loss-of-fxn-jdr.pdf
Folayan, MO, Haire BG, Adeniyi AA, Adeyemo WL.  2018.  Screening children for caries: an ethical dilemma in Nigeria. New Bioethics . 1-15:doi:10.1080/20502877.2018.1448251.
Sartelli, M, Kluger Y, Ansaloni L, Coccolini F, Baiocchi GL, Hardcastle TC, Moore EE, May AK, Itani KMF, Fry DE, others.  2018.  Knowledge, awareness, and attitude towards infection prevention and management among surgeons: identifying the surgeon champion. World journal of emergency surgery. 13:1–6., Number 1: BioMed Central Abstract
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Sartelli, M, Kluger Y, Ansaloni L, Hardcastle TC, Rello J, Watkins RR, Bassetti M, Giamarellou E, Coccolini F, Abu-Zidan FM, others.  2018.  Raising concerns about the Sepsis-3 definitions. World Journal of Emergency Surgery. 13:1–9., Number 1: BioMed Central Abstract
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Awoyemi, MO, Hammed OS, Falade SC, Arogundade AB, Olayode FA, Olurin OT, Ajama OD, Onyedim GC.  2017.  Evidence of basement controlled faulting of cretaceous strata in the Middle Benue Trough, Nigeria from lineament analysis of gravity data, 2017. 19(1):69-83. Abstract
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