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2020
Aluko, OO, Oloruntoba EO, Ana GREE, Hammed TB, Afolabi OT.  2020.  {Characteristics of co-composts produced from raw faecal sludge and organic market waste in Osun State, Southwest Nigeria}, aug. International journal of recycling organic waste in agriculture. 9:333–347., Number 4: Islamic Azad University-Isfahan (Khorasgan) Branch- Iran AbstractWebsite

Purpose Faecal sludge (FS) and organic market waste (MW) have resources that could be recovered by co-composting though not fully explored under changing climatic conditions in Nigeria. This study explored the characteristics and nutrient quality of co-composts produced from pre-treated FS and MW feedstocks in Nigeria. Methods The study was exploratory and analytical in design and co-composting was purposively selected for resource-recovery. The raw faecal sludge (FS) was harvested from septic tanks of households (50%) and institutions (50%) through mechanical evacuation service trucks and dewatered using 0.1% gradient sand filter. The biodegradable MW was sorted and used for further studies. The dewatered FS (DFS) and MW were mixed in ratios 1:3, 1:5 and 1:7, respectively with DFS and MW as controls. Each of the mixes was made into 1m3 heap and co-composted using the windrow method. The experiments were monitored for 88 days with fortnight composite sampling from each mix (13-weeks). The samples were analyzed for temperature, pH, moisture-contents, micronutrients, macronutrients and pollutants using Standard Methods. Results At maturity, N:P:K (%) indicate good composts at 9: 5: 4, 18: 7: 19 and 3: 3: 1 in the 1: 3, 1: 5 and 1: 7 mixes, respectively, while those of controls were: 19:12:12 (DFS) and 17:14:11(MW) with no significant differences between experimental and control mixes. Also, four factors extracted (pollutants, agronomic, macronutrients and micronutrients), explained 78.2% variability. Conclusion The matured co-compost satisfied nutrients and pollutants quality for agricultural use, recovered organic fertiliser from raw domestic and institutional faecal sludge and market waste.

Ammar, N, M. Aly N, Folayan M, Mohebbi S, Attia S, Böttger S, Howaldt H-P, Khader Y, Maharani D, Rahardjo A, Khan I, Madi M, Shamala A, Al-Batayneh O, Rashwan M, Pavlić V, Cicmil S, Galluccio G, Polimeni A, El Tantawi M.  2020.  Knowledge of Dental Academics about the COVID-19 Pandemic: A Multi-Country Online Survey, 2020/11/02. Abstract
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Collaborators, GBD, Murray C, Cristiana A, Abbas K, Abbasi M, Abbasi-Kangevari M, Abd-Allah F, Abdollahi M, Abedi P, Abedi A, Abolhassani H, Aboyans V, Guimarães Abreu L, Abrigo M, Abu-Gharbieh E, Haimed A, Medina-Solís CE, I. Abushouk A, Acebedo A, Bekuma T.  2020.  Five insights from the Global Burden of Disease Study 2019, 2020/10/17. 396:1135-1159. Abstract
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Lozano, R, Fullman N, Mumford J, Knight M, Barthelemy C, Cristiana A, Abbastabar H, Abd-Allah F, Abdollahi M, Abedi A, Abolhassani H, Eshete A, Guimarães Abreu L, Abrigo M, Haimed A, I. Abushouk A, Adabi M, Adebayo O, Adekanmbi V.  2020.  Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019, 2020/10/17. 396:1250-1284. Abstract
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Ammar, N, M. Aly N, Folayan M, Khader Y, Virtanen J, Al-Batayneh O, Mohebbi S, Attia S, Howaldt H-P, Böttger S, Maharani D, Rahardjo A, Khan I, Madi M, Rashwan M, Pavlić V, Cicmil S, Choi Y-H, Joury E, El Tantawi M.  2020.  Behavior change due to COVID-19 among dental academics-The theory of planned behavior: Stresses, worries, training, and pandemic severity, 2020/09/29. 15::e0239961. Abstract
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James, S, Castle C, Dingels Z, Fox J, Hamilton E, Liu Z, Roberts N, Sylte D, Bertolacci G, Cunningham M, Henry N, LeGrand K, Abdelalim A, Abdollahpour I, Suliankatchi R, Abedi A, Abegaz K, Eshete A, I. Abushouk A.  2020.  Estimating global injuries morbidity and mortality: Methods and data used in the Global Burden of Disease 2017 study, 2020/08/24. 26:injuryprev-2019. Abstract
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Kinyoki, D, Ross J, Lazzar-Atwood A, Munro S, Schaeffer L, Abbasalizad Farhangi M, Abbasi M, Abbastabar H, Abdelalim A, Abdoli A, Abdollahi M, Abdollahpour I, Abdulkader R, Dereje N, Abebo T, Abegaz K, Abolhassani H, Guimarães Abreu L, Abrigo M, Hay S.  2020.  Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017, 2020/08/01. 26:1-1. Abstract
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Alhajj, M, Omar R, Khader Y, Celebić A, El Tantawi M, Folayan M, Al-Maweri S, Halboub E, Alkheraif A, Sousa-Neto M, Vukovic A, Arheiam A, Ismail I, Abdullah A, Amran A, Kohli S, Ariffin Z, Kocaelli H, Khan DS, Muhammad F.  2020.  Happiness among dentists: a multi-scale, multi-national study from 21 countries, 2020/06/05. 70 Abstract
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Kinyoki, D, Ross J, Lazzar-Atwood A, Munro S, Schaeffer L, Abbasalizad Farhangi M, Abbasi M, Abbastabar H, Abdelalim A, Abdoli A, Abdollahi M, Abdollahpour I, Suliankatchi R, Dereje N, Abebo T, Abegaz K, Abolhassani H, Guimarães Abreu L, Abrigo M, Hay S.  2020.  Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017, 2020/05/01. 26:1-10. Abstract
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Arogundade, AB, Hammed OS, Awoyemi MO, Falade SC, Ajama OD, Olayode FA, Adebayo AS, Olabode AO.  2020.  Analysis of aeromagnetic anomalies of parts of Chad Basin, Nigeria, using high-resolution aeromagnetic data, 2020. 6(3):1545-1556.: Springer Abstract
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Arogundade, AB, Hammed OS, Awoyemi MO, Falade SC, Ajama OD, Olayode FA, Adebayo AS, Olabode AO.  2020.  Analysis of aeromagnetic anomalies of parts of Chad Basin, Nigeria, using high-resolution aeromagnetic data, 2020. Modeling Earth Systems and Environment, Springer . 6(3):1545-1556.: Springer Abstract

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Arogundade, AB, Awoyemi MO, Hammed OS, Falade SC, Ajama OD.  2020.  Structural Investigation of Zungeru-Kalangai Fault Zone, Nigeria using Aeromagnetic and Remote Sensing Data, 2020. Abstract
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Arogundade, AB, Awoyemi MO, Hammed OS, Falade SC, Ajama OD.  2020.  Structural Investigation of Zungeru-Kalangai Fault Zone, Nigeria using Aeromagnetic and Remote Sensing Data, 2020. Abstract
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Oluwole, OG, Kuivaniemi H, Abrahams S, Haylett WL, Vorster AA, Van Heerden CJ, Kenyon CP, Tabb DL, Fawale MB, Sunmonu TA, Ajose A, Olaogun MO, Rossouw AC, Van Hillegondsberg LS, Carr J, Ross OA, Komolafe MA, Tromp G, Bardien S.  2020.  Targeted next-generation sequencing identifies novel variants in candidate genes for Parkinson's disease in Black South African and Nigerian patients, 2020. BMC Medical Genetics. 21(1) Abstract

Background: The prevalence of Parkinson's disease (PD) is increasing in sub-Saharan Africa, but little is known about the genetics of PD in these populations. Due to their unique ancestry and diversity, sub-Saharan African populations have the potential to reveal novel insights into the pathobiology of PD. In this study, we aimed to characterise the genetic variation in known and novel PD genes in a group of Black South African and Nigerian patients. Methods: We recruited 33 Black South African and 14 Nigerian PD patients, and screened them for sequence variants in 751 genes using an Ion AmpliSeq™ Neurological Research panel. We used bcftools to filter variants and annovar software for the annotation. Rare variants were prioritised using MetaLR and MetaSVM prediction scores. The effect of a variant on ATP13A2's protein structure was investigated by molecular modelling. Results: We identified 14,655 rare variants with a minor allele frequency ≤ 0.01, which included 2448 missense variants. Notably, no common pathogenic mutations were identified in these patients. Also, none of the known PD-associated mutations were found highlighting the need for more studies in African populations. Altogether, 54 rare variants in 42 genes were considered deleterious and were prioritized, based on MetaLR and MetaSVM scores, for follow-up studies. Protein modelling showed that the S1004R variant in ATP13A2 possibly alters the conformation of the protein. Conclusions: We identified several rare variants predicted to be deleterious in sub-Saharan Africa PD patients; however, further studies are required to determine the biological effects of these variants and their possible role in PD. Studies such as these are important to elucidate the genetic aetiology of this disorder in patients of African ancestry.

Lynch, K, Omisore A, Atkinson T, Famurewa O, Vera J, Kingham T, Alatise O, Hricak H, Morris E, Sutton E.  2020.  Multistakeholder Needs Assessment to Inform the Development of an mHealth-Based Ultrasound-Guided Breast Biopsy Training Program in Nigeria, 11. JCO Global Oncology. 6:1813-1823. Abstract
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Azeez, MO, Christensen JT, Ravnskov S, Heckrath GJ, Labouriau R, Christensen BT, Rubæk GH.  2020.  Phosphorus in an arable coarse sandy soil profile after 74 years with different lime and P fertilizer applications. Geoderma. 376(2020):1-10.geoderma.pdf
Hassan, IA, Adegbola AJ, Soyinka JO, Onyeji CO, Bolaji OO.  2020.  Post-Marketing Surveillance of Quality of Artemether Injection Marketed in Southwest Nigeria. The American Journal of Tropical Medicine and Hygiene. 103(3):1258.: The American Society of Tropical Medicine and Hygiene Abstract
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2019
Folayan, M, Haire B, Peterson K, Yakubu A, Tegli J, Brown B.  2019.  Chapter 17: Criminalisation and "Reckless" Ebola Transmission: Theorizing Ethical Obligations to Seek Care, 2019/07/01. Abstract
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Salpietro, V, Dixon CL, Guo H, Bello OD, Vandrovcova J, Efthymiou S, Maroofian R, Heimer G, Burglen L, Valence S et al..  2019.  AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders, 2019. Nature Communications. 10(1) Abstract

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission.

Hammed, OS, Adagunodo TA, Awoyemi MO, Arogundade AB, Ajama OD, Sapele FO, Usikalu MR, Olanrewaju AM, Akinwumi SA, Ogunwale EI.  2019.  Identification of tsunamigenic earthquake zones in oceanic ridges and trenches, 2019. 38(2):103. Abstract
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Hammed, OS, Adagunodo TA, Awoyemi MO, Arogundade AB, Ajama OD, Sapele FO, Usikalu MR, Olanrewaju AM, Akinwumi SA, Ogunwale EI.  2019.  Identification of tsunamigenic earthquake zones in oceanic ridges and trenches, 2019. 38(2):103. Abstract
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Akinyemi, RO, Sarfo FS, Akinyemi J, Singh A, Onoja Akpa M, Akpalu A, Owolabi L, Adeoye AM, Obiako R, Wahab K, Sanya E, Komolafe M, Ogbole G, Fawale M, Adebayo P, Osaigbovo G, Sunmonu T, Olowoyo P, Chukwuonye I, Obiabo Y, Adeniji O, Fakunle G, Melikam E, Saulson R, Yaria J, Uwanruochi K, Ibinaiye P, Amusa GA, Yahaya IS, Dambatta AH, Faniyan M, Olowoniyi P, Bock-Oruma A, Joseph OC, Oguntade A, Kolo P, Laryea R, Lakoh S, Uvere E, Farombi T, Akpalu J, Oyinloye O, Appiah L, Calys-Tagoe B, Shidali V, Tabari NA, Adebayo O, Efidi R, Adeleye O, Owusu D, Ogunjimi L, Aridegbe O, Imoh CL, Sanni T, Gebreziabher M, Hemant T, Arulogun O, Ogunniyi A, Jenkins C, Owolabi M, Ovbiagele B.  2019.  Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study, 2019. International Journal of Stroke. 14(1) Abstract

Background: It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective: To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods: A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results: Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25–1.81) and a family history of stroke (OR 1.20, 1.03–1.39) while Islamic religion (OR=0.82, CI: 0.72–0.94), being currently unmarried (OR = 0.81, CI: 0.70–0.92), and alcohol use (OR = 0.78, CI: 0.67–0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03–1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65–0.96). Conclusion: To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.

Chelban, V, Wilson MP, Warman Chardon J, Vandrovcova J, Zanetti MN, Zamba-Papanicolaou E, Efthymiou S, Pope S, Conte MR, Abis G et al..  2019.  PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation, 2019. Annals of Neurology. 86(2) Abstract

Objective: To identify disease-causing variants in autosomal recessive axonal polyneuropathy with optic atrophy and provide targeted replacement therapy. Methods: We performed genome-wide sequencing, homozygosity mapping, and segregation analysis for novel disease-causing gene discovery. We used circular dichroism to show secondary structure changes and isothermal titration calorimetry to investigate the impact of variants on adenosine triphosphate (ATP) binding. Pathogenicity was further supported by enzymatic assays and mass spectroscopy on recombinant protein, patient-derived fibroblasts, plasma, and erythrocytes. Response to supplementation was measured with clinical validated rating scales, electrophysiology, and biochemical quantification. Results: We identified biallelic mutations in PDXK in 5 individuals from 2 unrelated families with primary axonal polyneuropathy and optic atrophy. The natural history of this disorder suggests that untreated, affected individuals become wheelchair-bound and blind. We identified conformational rearrangement in the mutant enzyme around the ATP-binding pocket. Low PDXK ATP binding resulted in decreased erythrocyte PDXK activity and low pyridoxal 5′-phosphate (PLP) concentrations. We rescued the clinical and biochemical profile with PLP supplementation in 1 family, improvement in power, pain, and fatigue contributing to patients regaining their ability to walk independently during the first year of PLP normalization. Interpretation: We show that mutations in PDXK cause autosomal recessive axonal peripheral polyneuropathy leading to disease via reduced PDXK enzymatic activity and low PLP. We show that the biochemical profile can be rescued with PLP supplementation associated with clinical improvement. As B6 is a cofactor in diverse essential biological pathways, our findings may have direct implications for neuropathies of unknown etiology characterized by reduced PLP levels. ANN NEUROL 2019;86:225–240.