Publications

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Oyekunle, JAO, Adekunle AS, Ogunfowokan AO, Akanni MS, Coker OS.  2012.   Agama Lizard. A Potential Biomarker of Environmental Heavy Metal Pollution Assessment. J of Environ. Sci. and Tech. 6(12):458–463.
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Cooper, KA, Adelekan DA, Esimai OA, Cleves N-CA, Thuruham DT.  2002.  ) Lack of influence of red palm oil on severity on malarial infection in preschool Nigerian infants.. Transactions of the Royal Society of Tropical Medicine and Hygiene. 96:216-223.
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Birindelli, A, Sartelli M, Di Saverio S, Coccolini F, Ansaloni L, van Ramshorst GH, Campanelli G, Khokha V, Moore EE, Peitzman A, others.  2017.  2017 update of the WSES guidelines for emergency repair of complicated abdominal wall hernias. World journal of emergency surgery. 12:1–16., Number 1: BioMed Central Abstract
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Birindelli, A, Sartelli M, Di Saverio S, Coccolini F, Ansaloni L, van Ramshorst GH, Campanelli G, Khokha V, Moore EE, Peitzman A, others.  2017.  2017 update of the WSES guidelines for emergency repair of complicated abdominal wall hernias. World journal of emergency surgery. 12:1–16., Number 1: BioMed Central Abstract
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Olabanji, SO, Omobuwajo OR, Ceccata D, Adebajo AC, Buoso MC, Moschini G.  2008.  Accelector-based analytical technique in the study of some anti-diabetic medicinal plants of Nigeria. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms . Vol. 266(10):2387-2390.
Ogunfowokan, AO, Oyekunle JAO, Akanni MS, Coker OS.  2012.  Agama lizard: A potential biomarker of environmental heavy metal pollution assessment. African Journal of Environmental Science and Technology . 6(12):458-463.
Owolabi, MO, Salaam K, Ogunniyi A, Ogbole GO, Akinyemi R, Mongkolwat P, Omisore AD, Agunloye AM, Makanjuola A, Efidi R, Odo J, Akpalu A, Sarfo F, Owolabi L, Obiako R, Wahab K, Adebayo P, Komolafe A, Osaigbovo G, Sunmonu T, Olowoyo P, Chukwuonye I, Obiabo Y, Ibinaiye P, Dambatta A, Mensah Y, Abdul S, Olabinri E, Ikubor J, Oyinloye O, Odunlami F, Akpa O, Melikam S, Saulson R, Ovbiagele B.  2017.  AIM on Clear Canvas Enriched Stroke Phenotyping Software (ACCESS).
Salpietro, V, Dixon CL, Guo H, Bello OD, Vandrovcova J, Efthymiou S, Maroofian R, Heimer G, Burglen L, Valence S et al..  2019.  AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders, 2019. Nature Communications. 10(1) Abstract

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission.

Oyedapo, O, Agbedahunsi JM, Cyril-Olutayo M.  2017.  Anti-sickling activities of the stem bark of three Khaya species found in Nigeria: K. senegalensis A. Juss., K. grandifoliola, (Welw) CDC., and K. ivorensis A. Chev., 03. Nigerian Journal of Natural Products and Medicine. 20:161. Abstract
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Akanji, O, Cyril-Olutayo M, Elufioye T, Ogunsusi O.  2016.  The antimalaria effect of Momordica charantia L. and Mirabilis jalapa leaf extracts using animal model, 06. Journal of Medicinal Plants Research. 10:344-350. Abstract
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Omonkhua, A, Cyril-Olutayo M, Akanbi O, Adebayo O.  2013.  Antimalarial, hematological, and antioxidant effects of methanolic extract of Terminalia avicennioides in Plasmodium berghei-infected mice, 07. Parasitology research. 112 Abstract
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Chary, S, Aderogba M, Moyo M, Mcgaw L, Mulaudzi R, Staden J.  2017.  Antimicrobial, antioxidant and cytotoxicity of isolated compounds from leaves of Pappea capensis, 01. South African Journal of Botany. 108:272-277. Abstract
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Sartelli, M, Weber DG, Ruppé E, Bassetti M, Wright BJ, Ansaloni L, Catena F, Coccolini F, Abu-Zidan FM, Coimbra R, others.  2016.  Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA). World journal of emergency surgery. 11:1–32., Number 1: Springer Abstract
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Akanbi, O, Omonkhua A, Cyril-Olutayo M, Fasimoye R.  2011.  The antiplasmodial activity of Anogeissus leiocarpus and its effect on oxidative stress and lipid profile in mice infected with Plasmodium bergheii, 06. Parasitology research. 110:219-26. Abstract
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Cyril-Olutayo, M, Elujoba AA, Durosinmi M.  2008.  Antisickling properties of Carica papaya Linn, 01. 1:56-66. Abstract
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Cyril-Olutayo, M, Elujoba AA, Durosinmi M.  2009.  Antisickling properties of the fermented mixture of Carica papaya Linn and Sorghum bicolor (L.) Moench, 04. African Journal of Pharmacy and Pharmacology. 3 Abstract
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Akinyemi, R, Tiwari HK, Arnett DK, Ovbiagele B, Irvin MR, Wahab K, Sarfo F, Srinivasasainagendra V, Adeoye A, Perry RT, Akpalu A, Jenkins C, Arulogun O, Gebregziabher M, Owolabi L, Obiako R, Sanya E, Komolafe M, Fawale M, Adebayo P, Osaigbovo G, Sunmonu T, Olowoyo P, Chukwuonye I, Obiabo Y, Onoja A, Akinyemi J, Ogbole G, Melikam S, Saulson R, Owolabi M.  2018.  APOL1, CDKN2A/CDKN2B, and HDAC9 polymorphisms and small vessel ischemic stroke, 2018. Acta Neurologica Scandinavica. 137(1) Abstract

Objective: Worldwide, the highest frequencies of APOL1-associated kidney variants are found in indigenous West Africans among whom small vessel disease (SVD) ischemic stroke is the most common stroke phenotype. The objective of this study was to investigate the association and effect sizes of 23 selected SNPs in 14 genes of relevance, including the APOL1 G1 variants, with the occurrence of SVD ischemic stroke among indigenous West African participants in the Stroke Investigative Research and Education Network (SIREN) Study. Materials and Methods: Cases were consecutively recruited consenting adults (aged 18 years or older) with neuroimaging—confirmed first clinical stroke. Stroke-free controls were ascertained using a locally validated version of the Questionnaire for Verifying Stroke-Free Status (QVSFS). Logistic regression models adjusting for known vascular risk factors were fitted to assess the associations of the 23 SNPs in rigorously phenotyped cases (N = 154) of SVD ischemic stroke and stroke-free (N = 483) controls. Results: Apolipoprotein L1 (APOL1) rs73885319 (OR = 1.52; CI: 1.09-2.13, P-value =.013), rs2383207 in CDKN2A/CDKN2B (OR = 3.08; CI: 1.15-8.26, P –value =.026) and rs2107595 (OR = 1.70; CI: 1.12-2.60, P-value =.014) and rs28688791 (OR = 1.52; CI: 1.03-2.26, P-value =.036) in HDAC9 gene were associated with SVD stroke at 0.05 significance level. Polymorphisms in other genes did not show significant associations. Conclusion: This is the first report of a specific association of APOL1 with a stroke subtype. Further research is needed to confirm these initial findings and deepen understanding of the genetics of stroke in people of African ancestry with possible implications for other ancestries as all humans originated from Africa.

Folayan, MO, Chukumah NM, Onyejeka N, Adeniyi A, Olatosi O.  2014.  Appraisal of the national response to caries epidemic in children in Nigeria. BMC Oral Health . 14(1):76.doi:10.1186/1472-6831-14-76.
Folayan, M, Sam-Agudu N, Adeniyi A, Oziegbe E, Nneka M, Chukwumah B, Mapayi.  2020.  Article A proposed one-stop-shop approach for the delivery of integrated oral, mental, sexual and reproductive healthcare to adolescents in Nigeria, 2020/10/21. 37 Abstract
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