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Azeez, MO, Christensen JT, Ravnskov S, Heckrath GJ, Labouriau R, Christensen BT, Rubæk GH.  2020.  Phosphorus in an arable coarse sandy soil profile after 74 years with different lime and P fertilizer applications. Geoderma. 376(2020):1-10.geoderma.pdf
Azeez, MO, O.O.Adesanwo, Adepetu JA.  2015.  Effect of Copper (Cu) Effect of copper application on soil available nutrients and uptake. . African Journal of Agricultural Research. 10(5):359-364.
Ayorinde, AT, Makanjuola GA, Aluko OB, Owolarafe OK, Sanni LA.  2019.  Performance evaluation of a kenaf decorticator. Agricultural Engineering International: CIGR Journal. 21:192–202., Number 1 Abstract
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Ayoola, TJ.  2013.  Nigeria-China Trade Relations: Implication on the Nigerian Domestic Economy. Research Journal of Finance and Accounting. 4(17):91-97.
Ayoola, OO, Bolarinwa RA, Onakpoya UU, Adedeji TA, Onwuka CC, Idowu BM.  2018.  Intima-media thickness of the common femoral artery as a marker of leg ulceration in sickle cell disease patients. Blood advances. 2:3112–3117., Number 22: American Society of Hematology Washington, DC Abstract
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Ayoola, O, Bolarinwa R, Onigbinde S, Onakpoya O, Asaleye M, Odedeyi A.  2019.  Intima-media thickness of the common carotid arteries as a marker of retinopathy in sickle cell disease, 2019/07/05. 39 Abstract

Purpose:This study was conducted to test the hypothesis that the carotid intima-media thickness (CIMT) is higher in patients with sickle cell disease (SCD) than in the normal population, and to determine the relationships of the CIMT with central retinal artery (CRA) and renal artery Doppler indices.
Methods:
Forty-four confirmed steady-state SCD patients aged 16 years and above were recruited consecutively. The Doppler velocimetric indices of their right renal artery and both CRAs were obtained. The CIMT was also measured on each side via B-mode ultrasonography. The subjects were categorized by age and sex. Mean and median values for each group were determined. The Spearman correlation test was used to quantify the relationships between CIMT and the Doppler parameters.
Results:
The participants had a median age of 24.50 years (interquartile range, 12.50 to 36.50 years). Twenty-three were men (52.3%) and 21 were women (47.7%). The median CIMT was 0.70 mm (IQR, 0.50 to 0.90 mm). Significant correlations with the CIMT were found for the CRA peak systolic velocity (r=0.312, P=0.003), the renal artery resistivity index (RI) (r=0.284, P=0.007), and the renal artery pulsatility index (PI) (r=0.273, P=0.010). There was no significant relationship between the CIMT and the CRA end-diastolic velocity, CRA RI, or CRA PI.
Conclusion:
The CIMT was higher in SCD patients than in the normal population. In addition, the CIMT was significantly correlated with the CRA peak systolic velocity, the renal artery RI, and the renal artery PI.

Ayoola, O, Soyoye D, Dawha S, Ikem R, Onakpoya O, Adedeji T, Arogundade F.  2016.  The Relationship between Central Retinal Artery Resistive Index and Measures of Renal Function in Type 2 Diabetes, 2016/01/01. 06:146-151. Abstract
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Ayoola, TJ.  2011.  Gas Flaring and its Implication for Environmental Accounting in Nigeria. Journal of Sustainable Development. 4(5):244-250.11356-37509-1-pb.pdf
Ayoola, O, Bolarinwa R, Onwuka C, Idowu B, Aderibigbe A.  2020.  Association between Endothelial Dysfunction, Biomarkers of Renal Function, and Disease Severity in Sickle Cell Disease, 2020/02/27. 1:79-85. Abstract

BackgroundEndothelial dysfunction (ED), as ascertained by brachial artery flow-mediated dilation (FMD), is a known feature of sickle cell disease (SCD), which is present both in crisis and in steady state. The assessment of FMD was introduced to examine the vasodilator function. Our objective was to establish the relationship between ED determined by FMD, biomarkers of renal dysfunction, and biomarkers of disease severity in SCD subjects asymptomatic of renal disease.
Methods
We enrolled 44 patients with homozygous SCD in steady state and 33 age- and sex-matched controls between 2013 and 2014 in a tropical tertiary hospital. Ultrasonographic FMD of the right brachial artery, renal arterial Doppler, complete blood count, creatinine, fetal hemoglobin, soluble P-selectin, and cystatin C (Cys-C) levels were determined. Using the median FMD value of the control group, the SCD subjects were further classified into two groups for comparison.
Results
The median FMD in SCD subjects of 3.44 (IQR, 0.00–7.08) was significantly lower than that of controls, which was 5.35 (IQR, 3.60–6.78; P =0.04). There was negative correlation between FMD and Cys-C levels ( r =−0.372; P =0.01) along with renal artery resistivity index (RARI; r =−0.307; P =0.04) in SCD subjects. Additionally, Cys-C level was significantly higher in SCD subjects with FMD<5.35.
Conclusions
Brachial artery FMD was significantly lower in SCD subjects compared with a control group. Cys-C and RARI show a negative correlation with FMD, indicating that renal function is related to ED in SCD.

Ayoola, O, Onuwaje M, Akintomide A.  2016.  Sonographic assessment of the carotid intima-media thickness on B-mode ultrasonography in a Nigerian population, 2016/01/18. 56:357-61. Abstract

Background:Hypertension is a common health problem and a major risk factor of cardiovascular disease. The most important mechanism by which hypertension acts as a cardiovascular risk factor is the induction of arteriosclerosis. The early phase of atherosclerosis before its clinical manifestation can be studied using B-mode ultrasonography.
Aims and objectives:
This study evaluated the intima-media thickness of the common carotid artery (CCA), carotid intima-media thickness (CIMT) of subjects with essential hypertension as a way of detecting these early changes of atherosclerosis.
Subjects and methods:
The study was performed on 200 subjects with newly diagnosed hypertension and 100 apparently normal controls that were consecutively recruited by a cardiologist. An ultrasound examination of both CCA were done to obtain the CIMT. Data were analyzed using the SPSS data analysis software.
Results:
The CIMT of males were greater in the hypertensive group compared to the controls (0.10 ± 0.02 cm vs. 0.077 ± 0.02 cm [P < 0.0001] and 0.10 ± 0.02 cm vs. 0.078 ± 0.02 cm [P < 0.0001] for the right and left sides, respectively). The female group showed a similar pattern of results (0.09 ± 0.02 cm vs. 0.072 ± 0.02 cm [P < 0.0001] and 0.1 ± 0.02 cm vs. 0.076 ± 0.02 cm [P < 0.0001] for the right and left sides respectively).
Conclusion:
A statistically significant increase in CIMT was noted in both male and female hypertensives in comparison to a normal population.

Ayoola, TJ, Obokoh LO.  2018.  Corporate Governance and Financial Distress in the Banking Industry: Nigerian Experience. Journal of Economics and Behavioural Studies. 10(1):182-193.2101-13-3095-1-10-20180315.pdf
Ayoola, TJ, Oyerinde AA.  2016.  Efficiency and Financial Distress in the Nigerian Banking Industry. ICAN Journal of Accounting and Finance. 1(1):101-121.
Ayoola, MD, Adebajo AC, Obuotor EM, Oladapo TO, Fleischer TC.  2017.  Anti-hyperglycaemic and anti-oxidant activities of five Nigerian antidiabetic plants, jun. Journal of Science and Technology (Ghana). 37(2):71–84., Number 2: African Journals Online ({AJOL}) AbstractWebsite

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Ayoola, O, Bolarinwa R, Onakpoya U, Adedeji T, Onwuka C, Idowu B.  2018.  Intima-media thickness of the common femoral artery as a marker of leg ulceration in sickle cell disease patients, 2018/11/27. 2:3112-3117. Abstract

Leg ulceration is a debilitating chronic complication of sickle cell disease (SCD) the pathogenesis of which is yet to be fully elucidated. We hypothesized that SCD patients with histories of previous leg ulcers would have intima hyperplasia of the common femoral artery (CFA). We enrolled 44 SCD patients and 33 age-matched and sex-matched controls with hemoglobin AA. Anthropometric measurements, biochemical parameters, and sonographic intima-media thickness (IMT) of the CFA were determined. The median CFA IMT in SCD limbs with history of leg ulcers (SWLU) was 1.0 mm, whereas it was 0.7 mm in SCD limbs with no history of leg ulcer (SNLU) and 0.60 mm in controls (P < .001). Among the SNLU, 70.3% had CFA IMT <0.9 mm, whereas only 29.7% had CFA IMT ≥0.9 mm. Conversely, only 20.8% of SWLU had CFA IMT <0.9 mm, whereas the remaining 79.2% had CFA IMT ≥0.9 mm. All the controls had CFA IMT <0.9 mm. Binary logistic regression to determine the odds of having leg ulcer among SCD limbs with CFA IMT of ≥0.9 mm yielded an odds ratio of 9, indicating that SCD limbs with CFA IMT ≥0.9 mm had a 9 times greater risk of having leg ulcer compared with those with CFA IMT <0.9 mm. There is a significant increase in the CFA IMT of SCD limbs with ulcer compared with controls and SCD limbs without ulcer, suggesting that arterial vasculopathy plays a major role in the formation of these ulcers.

Ayoola, TJ.  2022.  Audit fees, audit seasonality and audit quality in Nigeria: a mediation analysis. Journal of Financial Reporting and Accounting.
Ayoola, O, Bolarinwa R, Onigbinde S, Onakpoya O, Asaleye M, Odedeyi A.  2019.  Intima-media thickness of the common carotid arteries as a marker of retinopathy in sickle cell disease, 2019/07/05. 39 Abstract

Purpose:This study was conducted to test the hypothesis that the carotid intima-media thickness (CIMT) is higher in patients with sickle cell disease (SCD) than in the normal population, and to determine the relationships of the CIMT with central retinal artery (CRA) and renal artery Doppler indices.
Methods:
Forty-four confirmed steady-state SCD patients aged 16 years and above were recruited consecutively. The Doppler velocimetric indices of their right renal artery and both CRAs were obtained. The CIMT was also measured on each side via B-mode ultrasonography. The subjects were categorized by age and sex. Mean and median values for each group were determined. The Spearman correlation test was used to quantify the relationships between CIMT and the Doppler parameters.
Results:
The participants had a median age of 24.50 years (interquartile range, 12.50 to 36.50 years). Twenty-three were men (52.3%) and 21 were women (47.7%). The median CIMT was 0.70 mm (IQR, 0.50 to 0.90 mm). Significant correlations with the CIMT were found for the CRA peak systolic velocity (r=0.312, P=0.003), the renal artery resistivity index (RI) (r=0.284, P=0.007), and the renal artery pulsatility index (PI) (r=0.273, P=0.010). There was no significant relationship between the CIMT and the CRA end-diastolic velocity, CRA RI, or CRA PI.
Conclusion:
The CIMT was higher in SCD patients than in the normal population. In addition, the CIMT was significantly correlated with the CRA peak systolic velocity, the renal artery RI, and the renal artery PI.

Ayoola, TJ, Inneh EG, Obokoh LO, Kolawole PE, Adeoye ET.  2022.  Competition and efficiency in an oligopolistic audit market: Evidence from the Nigerian banking industry. Banks and Bank Systems. 17(4):129-139.bbs_2022_04_ayoola.pdf
Ayoola, O, Bolarinwa RA, Aderibigbe A, Onigbinde S, Oguntade BP.  2019.  Portal Hypertension evolving from Sickled Hepatopathy: Could Hepatic venous Doppler ultrasound be beneficial in its evaluation?, 2019/11/01 135:109450. Abstract

Purpose:Sickle cell intrahepatic cholestasis involves sickling within hepatic sinusoids leading to vascular stasis and localized hypoxia resulting in ballooning of the hepatocytes causing a direct back pressure effect with resultant intracanalicular cholestasis. Vascular stasis may ultimately lead to portal hypertension. We proposed to document findings suggestive of portal hypertension evolving from hepatopathy in steady-state sickle cell disease (SCD) patients using hepatic venous Doppler ultrasound.
Methods:
This is a prospective case series of 6 SCD subjects in steady-state (median age, 30 years; range, 19-43), comprising of 3 males and 3 females, who underwent a routine Doppler ultrasound evaluation of their hepatic veins and were discovered to have an abnormal biphasic waveform pattern. Venous blood was obtained from all subjects to evaluate for P-selectin, homocysteine, foetal haemoglobin, haematocrit levels, white cell and platelet counts. Doppler ultrasound was also carried out on all subjects to evaluate for the hepatic waveform, right renal artery RI and PI along with the hepatic artery velocities.
Results:
All the 6 subjects had reduced haematocrit (median value of 21.5%; range, 18-25%) and some degree of renal dysfunction (plasma cystatin-C ranged from 1.6 to 12.2 mg/L). Elevated white cell count, hyperhomocysteinemia, reduced SpO2(<94.0%) and reduced estimated GFR (eGFR < 90 ml/min) was also noted in 4 subjects (66.7%). Similarly, 4 subjects (66.7%) had elevated RI in the right kidneys while 3 subjects (50.0%) had elevated PI in the right kidney.
Conclusion:
Doppler ultrasound Hepatic vein waveform analysis may be a useful examination in the evaluation of patients with SCD as it may elicit feature of portal hypertension. Further studies are suggested to confirm this in a larger population of SCD patients using the gold standard.

Ayoola, OO, Bolarinwa RA, Aderibigbe AS, Onigbinde SO, Oguntade BO.  2020.  Portal hypertension evolving from sickled hepatopathy: Could hepatic venous Doppler ultrasound be beneficial in its evaluation? Medical hypotheses. 135:109450.: Elsevier Abstract
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Ayoola, TJ, Oyerinde AA, Inneh GE.  2019.  Audit Market Concentration and Audit Fees: Empirical Evidence from Nigerian Deposit Money Banks. International Journal of Accounting and Management. 3(2):91-106.audit_market_concentration_and_audit_fees.pdf
Ayoola, O, Bolarinwa R, Onigbinde S, Onakpoya O, Asaleye M, Odedeyi A.  2019.  Intima-media thickness of the common carotid arteries as a marker of retinopathy in sickle cell disease, 2019/07/05. 39 Abstract

Purpose:This study was conducted to test the hypothesis that the carotid intima-media thickness (CIMT) is higher in patients with sickle cell disease (SCD) than in the normal population, and to determine the relationships of the CIMT with central retinal artery (CRA) and renal artery Doppler indices.
Methods:
Forty-four confirmed steady-state SCD patients aged 16 years and above were recruited consecutively. The Doppler velocimetric indices of their right renal artery and both CRAs were obtained. The CIMT was also measured on each side via B-mode ultrasonography. The subjects were categorized by age and sex. Mean and median values for each group were determined. The Spearman correlation test was used to quantify the relationships between CIMT and the Doppler parameters.
Results:
The participants had a median age of 24.50 years (interquartile range, 12.50 to 36.50 years). Twenty-three were men (52.3%) and 21 were women (47.7%). The median CIMT was 0.70 mm (IQR, 0.50 to 0.90 mm). Significant correlations with the CIMT were found for the CRA peak systolic velocity (r=0.312, P=0.003), the renal artery resistivity index (RI) (r=0.284, P=0.007), and the renal artery pulsatility index (PI) (r=0.273, P=0.010). There was no significant relationship between the CIMT and the CRA end-diastolic velocity, CRA RI, or CRA PI.
Conclusion:
The CIMT was higher in SCD patients than in the normal population. In addition, the CIMT was significantly correlated with the CRA peak systolic velocity, the renal artery RI, and the renal artery PI.

Ayoola, OO, Bolarinwa RA, Onwuka CC, Idowu BM, Aderibigbe AS.  2020.  Association Between Endothelial Dysfunction, Biomarkers of Renal Function and Disease Severity in Sickle Cell Disease. Kidney360. :10–34067.: Am Soc Nephrol Abstract
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