Cerebral oximetry in healthy adults: A comparison of three commercial Near-Infrared Spectrophotometers

Owojuyigbe, A, Adenekan A, Kawamae K, Suzuki H, Aaron O, Owojuyigbe T.  2021.  Cerebral oximetry in healthy adults: A comparison of three commercial Near-Infrared Spectrophotometers, 2021/02/01. 28:37-44.


Background: Cerebral oximetry is increasingly becoming a desirable form of monitoring inanaesthesia and critical care. Familiarity with normal values for each device is therefore important. We compared NIRO 300 and INVOS 5100 with the novel MASIMO O3 cerebral oximeter.
Methods: Regional cerebral oxygen saturations (rScO2) of nine healthy volunteers were
measured using NIRO 300, INVOS 5100, and MASIMO O3 under various conditions of hyperoxia, hypocapnia, and change in head position. Changes in vital signs and rScO2 were compared. Reliability analyses of the NIRS devices were performed using Intraclass Correlation Coefficients (ICC) estimates at 95% confidence interval based on 2-way mixed-effects model, multiple rater, and absolute-agreement and consistency selections. P <0.05 was considered statistically significant for this study.
Results: The mean (SD) baseline values from NIRO 300 and INVOS 5100 were comparable
[73.8% (4.2%) vs 73.4% (5.6%) respectively, (p = 0.84)]. The baseline from MASIMO O3 [66.8% (3.9%)] was significantly lower compared to NIRO 300 (p = 0.002), and INVOS 5100 (p = 0.011). Changes in head position were not associated with statistically significant changes in NIRS values (p > 0.05). Significant increases were recorded for each of the NIRS devices at FiO2 = 0.45 and FiO2 = 1 (p = 0.0001) and during supine hyperventilation (p = 0.0001). The Intraclass Correlation Coefficients (ICC) estimates based on 2-way mixed-effects model suggested poor absoluteagreement (0.63; 95% CI = 0.16 - 0.81), but good consistency (0.81; 95% CI = 0.77 - 0.85). Absolute-agreement and consistency tests for NIRO 300 and INVOS 5100 pairs were moderate (0.74; 95% CI = 0.68 - 0.79).
Conclusion: Findings of this study affirm that different NIRS devices give different estimates but similar trends during various interventions. Values from the novel MASIMO O3 were generally lower than NIRO 300 and INVOS 5100.