BIOGRAPHICAL SKETCH

 

NAME: Hassan, Muzamil Olamide

POSITION TITLE: Lecturer 1 and Consultant Nephrologist

 

EDUCATION/TRAINING

 

INSTITUTION AND LOCATION

DEGREE
(if applicable)

START DATE
MM/YYYY

END DATE
MM/YYYY

FIELD OF STUDY

Obafemi Awolowo University, Nigeria

MBCHB

09/1995

08/2005

Medicine and Surgery

NPMCN, Nigeria (Residency)

FMCP

01/2007

05/2012

Int. medicine/Nephrology

The Colleges of Medicine of South Africa

 

Cert Nephrology (SA) Phys

09/2012

10/2015

Nephrology

University of the Witwatersrand, South Africa

PHD

01/2013

12/2015

Internal medicine

A. Personal Statement

My long-term research interests involve exploring genetic component to cardiovascular and kidney health disparities in individuals of African ancestry and how alterations in gene expression contribute to non-diabetic kidney diseases. My academic training and research experience have provided me with an excellent background in the field of internal medicine, nephrology, clinical research and genetics. As a resident doctor at Obafemi Awolowo University Teaching Hospital, Ile-Ife, in collaboration with my co-workers, I studied epidemiology of chronic kidney disease in Nigeria. As a PhD student with Prof. Saraladevi Naicker at the University of the Witwatersrand, my research focused on the role of circulating endotoxaemia and gene polymorphisms for susceptibility and severity of cardiovascular disease in chronic kidney disease patients. In the course of my research project, I adopted various molecular based techniques to assess the role of circulating endotoxaemia as a pro-inflammatory mediator of atherosclerosis, and profiled APOL1 risk variants and inflammatory marker SNPs to explore the role genetics plays in contributing to the severity of atherosclerosis in CKD. My study provided evidence that suggested that additive contributions from circulating endotoxaemia, APOL1 polymorphisms and inflammatory genetic markers strongly enhance the severity of cardiovascular disease in chronic kidney disease patients with protection afforded by toll-like receptor-4 ASP299GLY polymorphism and transforming growth factor, and this work has been well received at national and international conferences. For my postdoctoral training, I will continue to build on my previous training in clinical nephrology and genetics by investigating the molecular mechanism of APOL1 associated atherosclerotic cardiovascular disease that will allow me to address additional questions regarding the impact of APOL1 risk variants on cardiovascular burden among different ethnic group in sub-Saharan Africa. This study will be scaled up to determine the contributory role of APOL1 variants on the burden of cardiovascular disease in HIV associated kidney disease patients. Currently, I am the principal investigator on research project titled “Prevalence and Pharmacogenomics of Tenofovir Nephrotoxicity in HIV-Infected Adults in South-Western Nigeria”. Most recently, I was awarded the Africa Research Excellence Fund Fellowship to validate the differential expression of microRNAs associated with the development of Kidney Tubular Dysfunction (KTD) among Nigerian HIV-Positive Patients.

B. Positions and Honors

Positions and Employment

2007 – 2012

Resident Doctor, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria

2012 – 2014

Fellow, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa

2014 –2019

Consultant Physician/Nephrologist, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, Nigeria

2019 ­­–

 

2019 –

 

2019 –

Lecturer 1, Department of Medicine Obafemi Awolowo University, Ile-Ife, Nigeria

Consultant Nephrologist, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria

Visiting Consultant Nephrologist, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, Nigeria

 

Other Experience and Professional Memberships

2009 -

2009 – 2010

Member, Nigerian Association of Nephrology

Associate Editor, Nigeria Journal of Postgraduate Medicine

2010 -

Member, International Society of Nephrology

2012 -

2013 -

2014 - 2021

2014 - 2019

2016 -  

2019 -

Member, Transplant Association of Nigeria

South African Renal Society

ISN Young Nephrologist Committee, member

ISN Interventional Nephrology Committee, member

ISN iNET-CKD Committee, member

Member, Editorial Board, Nigerian Journal of Transplantation

Honors

2011

ISN Schrier Fellow

2011

 

2011

Award of best abstract presentation at 5th Faculty Week of Faculty of Clinical Sciences, OAU, Ile-Ife

Award of best abstract presentation at 23rd Nigerian Association of Nephrology Conference

2012 – 2014

Award of International Society of Nephrology Fellowship

2014

Award of Best poster presentation (1st Runner up) at the satellite meeting of the World Congress of Nephrology 2015, Cape Town, South Africa

2014

Award of ISN World Congress of Nephrology 2015 Travel Grant

2016

2017

Award of ISN World Congress of Nephrology 2017 Travel Grant                 1st prize of the ISN Fellowship Awards 2017, WCN 2017, Mexico City

2017

Best Poster of the Conference, Satellite meeting of the World Congress of Nephrology 2017, Santiago de Queretaro, Mexico

 

C. Peer-reviewed Publications

 

Hassan MO, Owoyemi I, Abdel-Rahman EM, Ma JZ and Balogun RA. Association of race with in-hospital and post-hospitalization mortality in patients with acute kidney injury. Nephron. 2021;145(3):214-224

 

Hassan MO, Duarte R, Mabayoje VO, Dickens C, Lasisi AO and Naicker S. Design and methods of the prevalence and pharmacogenomics of tenofovir nephrotoxicity in HIV-positive adults in south-western Nigeria study. BMC Nephrology. 2020; 21:436 https://doi.org/10.1186/s12882-020-02082-3

 

Hassan MO, Oguntola SO, Duarte R, Naicker S. Cardiovascular disease in chronic kidney disease – a review of risk factors. African Journal of Nephrology. 2020; 23(1): 152-158

 

Hassan MO, Duarte R, Dickens R, Dix-Peek T, Naidoo S, Vachiat A, Grinter S, Manga P and Naicker S. Association of chronic inflammation and accelerated atherosclerosis among indigenous black population with chronic kidney disease. PLOSOne. 2020;15(7): e0232741.https://doi.org/10.1371/ journal. pone.0232741

 

Hassan MO, Duarte R, Dickens R, Dix-Peek T, Naidoo S, Vachiat A, Grinter S, Manga P and Naicker S. APOL1 genetic variants are associated with serum-oxidized low-density lipoprotein levels and subclinical atherosclerosis in South African CKD patients [published online ahead of print, 2020 Jun 11]. Nephron. 2020;1‐10. doi:10.1159/000507860.

 

Hassan MO, Duarte R, Dickens C, Dix-Peek T, Naidoo S, Vachiat A, Grinter S, Manga P, Naicker S. Interleukin-6 gene polymorphisms and interleukin-6 levels are associated with atherosclerosis in CKD patients. Clin Nephrol. 2020; 93 (Suppl1): S82-S86.

 

Oguntola SO, Hassan MO, Duarte R, Vachiat A, Manga P, Naicker S. Atherosclerotic vascular disease is more prevalent among black ESKD patients on long-term CAPD in South Africa – BMC Nephrol. 2019; Oct 30; 20 (1): 399. doi: 10.1186/s12882-019-1583-8.

 

Hassan MO, Duarte R, Dickens C, Dix-Peek T, Naidoo S, Vachiat A, Grinter S, Manga P, Naicker S. Interleukin-6 gene polymorhisms and interleukin-6 levels are associated with atherosclerosis in CKD patients. Clin Nephrol. 2019 Aug 20. doi: 10.5414/CNP92S114. [Epub ahead of print]

 

Hassan MO, Arogundade FA, Adelusola KA, Sanusi AA, Okunola OO, Omotoso BA, Oguntola SO, Akinsola A. Refractory Oedema Treated with Modified Peritoneo-Venous Shunt in Nephrotic Syndrome Patients. Afr. J. Med. Med. Sci. 2019; 48:7-16.

 

Arogundade FA, Akinbodewa AA, Sanusi AA, Okunola O, Hassan MO, Akinsola A. Clinical presentation and outcome of autosomal dominant polycystic kidney disease in Nigeria. Afri Health Sci. 2018; 18(3): 671-680.

 

Oguntola SO, Hassan MO, Duarte R, Dix-Peek T, Dickens C, Olorunfemi G, Vachiat A, Paget G, Manga P, Naicker S. Atherosclerotic vascular disease and its correlates in stable black South African kidney transplant recipients. Int J Nephrol Renovasc Dis. 2018 Jul 16; 11:187-193. doi: 10.2147/IJNRD.S160553. eCollection 2018.

 

Hassan MO, Duarte R, Dix-Peek T, Dickens C, Naidoo S, Vachiat A, Grinter S, Manga P, Naicker S. Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients. Int J Nephrol. 2018 Jun 6; 2018:8702372. doi: 10.1155/2018/8702372. eCollection 2018.

 

Hassan MO, Ogundapo AO, Lasisis AO. Oto-Renal Syndromes: Disorders of Shared Developmental Gene Polymorphisms and Overlapping Physiology. Afr. J. Med. Med. Sci. 2017; 46 (ahead of print).

 

Hassan MO, Duarte R, Dix-Peek T, Vachiat A, Dickens C, Grinter S, Naidoo S, Manga P and Naicker S. Volume Overload and Its Risk Factors in South African Chronic Kidney Disease Patients: An Appraisal of Bio-impedance Spectroscopy and Inferior Vena Cava Measurements. Clin Nephrol. 2016 Jul; 86(7):27-34. doi: 10.5414/CN108778.

 

Hassan MO, Duarte R, Dix-Peek T, Vachiat A, Naidoo S, Dickens C, Grinter S, Manga P and Naicker S. Correlation between Volume overload, Chronic Inflammation and Left Ventricular Dysfunction in Chronic Kidney Disease Patients. Clin Nephrol. 2016 Aug 10. DOI: 10.5414/CNP86S127

 

Arogundade FA, Hassan MO, Omotoso BA, Oguntola SO, Okunola OO, Sanusi AA and Akinsola A. Spectrum of kidney diseases in Africa: malaria, schistosomiasis, sickle cell disease, and toxins Clin Nephrol. 2016 Aug 10. [Epub ahead of print]

 

Bello IS, Arogundade FA, Hassan MO, Sanusi AA, Akinsola A. Prevalence of Hypertension and Associated Cardiovascular Risk Factors in Patients Attending a Family Practice Clinic in Ile-Ife, Southwest Nigeria. Tropical Journal of Nephrology 2013, 8(1&2):23-29.

 

Sanusi AA, Arogundade FA, Udo AI, Hassan MO, Oyewole O, Kolawole T, Akinsola A. Calciphylaxis Causing Digital, Gangrene in End Stage Renal Disease: A case report and review. West Afr J Med. 2013 Jan-Mar; 32(1):68-72.

 

Arogundade FA, Sanusi AA, Akinbodewa AA, Hassan MO, Omotosho BO, Balogun RA, and Akinsola A. Filter Membrane-Based Automated Therapeutic Plasma Exchange: A Report of Two Cases From Nigeria. Journal of Clinical Apheresis 2013; 28:78–83

 

Arogundade FA, Sanusi AA, Hassan MO, Gbadegesin A, Olarinoye OF, Otuyemi O, Akinsola A. Undiagnosed hypertension and proteinuria in naïve market population in ile-ife, Nigeria. Arab Journal of Nephrology and Transplant. 2011; 4(3): 141-6

 

Arogundade FA, Sanusi AA, Hassan MO, Akinsola A. The pattern, clinical characteristics and outcome of ESRD in Ile-Ife, Nigeria: Is there a change in trend? African Health Sciences 2011, 11(4): 594-601.

Arogundade FA, Sanusi AA, Hassan MO, Salawu L, Durosinmi MA, Akinsola A. An Appraisal of kidney dysfunction and its risk factors in patients with sickle cell disease. Nephron Clin Pract 2011; 118:c225-231.

 

Arogundade FA, Sanusi AA, Hassan MO, Udo AIA, Adelusola KA, Akinbodewa AA, Akinsola A. A prospective longitudinal follow-up study of the pattern, clinical presentation and outcome of lupus nephritis in adult Nigerians. Tropical Journal of Nephrology 2010; 5(2): 105-112.

 

D. Research Support

 

2013: Faculty Research Committee Grants, University of the Witwatersrand (1year).  The Role of Circulating Endotoxaemia as a Pro-inflammatory Mediator of Atherosclerosis in Chronic Kidney Disease Patients.

 

2014: AstraZeneca Research Trust Grant (2 years). The Role of Circulating Endotoxaemia and Gene Polymorphism for Susceptibility and Severity of Cardiovascular disease in Chronic Kidney Disease Patients. The project determined the pro-inflammatory effects of endotoxaemia that may be relevant to the development of atherosclerosis and to establish whether there is an additive contribution from genetic markers on the severity of cardiovascular disease among CKD patients (R 111, 600).

 

 

2017: GSK Africa NCD Open Lab Grant (2 years). Prevalence and Pharmacogenomics of Tenofovir Nephrotoxicity in HIV-Infected Adults in South-Western Nigeria (£ 110,140) – Ongoing.

 

2021: Africa Research Excellence Fund Fellowship (14 months). Training and Capacity building in Nephrogenomics - To validate the differential expression of microRNAs associated with the development of kidney tubular dysfunction.

 

F. Student Supervision

Completed:

Surname, Initial

Degree

Year

Title

Oguntola, SO

PhD

2018

Relationship of chronic inflammatory markers and dyslipidaemia to atherosclerotic vascular disease in

different categories of CKD patients

Bamikefa, T

FMCP

2019

Clinicopathologic pattern and correlation study of adult glomerulonephritides in a Nigerian tertiary health institution